A5068359564- Neuroscience of respiration and sleep
- Zebrafish Biomedical Research Applications
- Spinal Cord Injury Research
- Primate Behavior and Ecology
- Neural dynamics and brain function
- Neurogenesis and neuroplasticity mechanisms
- Neurological disorders and treatments
- Muscle activation and electromyography studies
- Virus-based gene therapy research
- Parkinson's Disease Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Spinal Dysraphism and Malformations
- Motor Control and Adaptation
- Bacteriophages and microbial interactions
- Cellular transport and secretion
- Transcranial Magnetic Stimulation Studies
- Herpesvirus Infections and Treatments
- Neurogenetic and Muscular Disorders Research
- Neuroscience and Neural Engineering
- Hemispheric Asymmetry in Neuroscience
- Cytomegalovirus and herpesvirus research
- RNA Interference and Gene Delivery
- Balance, Gait, and Falls Prevention
- Animal Vocal Communication and Behavior
- Neuroinflammation and Neurodegeneration Mechanisms
University College London
2021-2023
National Hospital for Neurology and Neurosurgery
2021-2023
University of Louisville
2017-2021
Elaborate behaviours are produced by tightly controlled flexor-extensor motor neuron activation patterns. Motor neurons regulated a network of interneurons within the spinal cord, but computational processes involved in control not fully understood. The neuroanatomical arrangement and premotor into topographic patterns related to their muscles is thought facilitate how information processed circuits. Rabies retrograde monosynaptic tracing has been used label innervating specific pools, with...
Dystonia, a neurological disorder defined by abnormal postures and disorganized movements, is considered to be neural circuit with dysfunction arising within between multiple brain regions. Given that spinal circuits constitute the final pathway for motor control, we sought determine their contribution this movement disorder. Focusing on most common inherited form of dystonia in humans, DYT1- TOR1A , generated conditional knockout torsin family 1 member A ( Tor1a ) gene mouse cord dorsal...
Abstract Neural circuitry in the lumbar spinal cord governs two principal features of locomotion, rhythm and pattern, which reflect intra- interlimb movement. These are functionally organized into a hierarchy that precisely controls stepping stereotypic, speed-dependent fashion. Here, we show specific component locomotor pattern can be independently manipulated. Silencing L2 interneurons project to L5 selectively disrupts hindlimb alternation allowing continuum walking hopping emerge from...
Within the cervical and lumbar spinal enlargements, central pattern generator (CPG) circuitry produces rhythmic output necessary for limb coordination during locomotion. Long propriospinal neurons that inter-connect these CPGs are thought to secure hindlimb-forelimb coordination, ensuring diagonal pairs move synchronously while ipsilateral out-of-phase stepping. Here, we show silencing long ascending (LAPNs) disrupts left-right coupling of each pair in adult rat overground locomotion on a...
Long ascending propriospinal neurons (LAPNs) are a subpopulation of spinal cord interneurons that directly connect the lumbar and cervical enlargements. Previously we showed, in uninjured animals, conditionally silencing LAPNs disrupted left-right coordination hindlimbs forelimbs context-dependent manner, demonstrating secure alternation fore- hindlimb pairs during overground stepping. Given ventrolateral location LAPN axons white matter, many likely remain intact following incomplete,...
Administration of substances into neonatal mice is required for early treatment with pre-clinical therapeutics, delivery recombination-inducing substances, and dosing viruses or toxins, amongst other things. Several injection routes mouse pups are possible, including intravenous intracerebroventricular, each their own advantages limitations. Here, we describe a simple rapid protocol the intraperitoneal systemic dosing. By detaching 30-gauge needle from its plastic hub inserting it...
Abstract Elaborate behaviours are produced by tightly controlled flexor-extensor motor neuron activation patterns. Motor neurons regulated a network of interneurons within the spinal cord, but computational processes involved in control not fully understood. The neuroanatomical arrangement and premotor into topographic patterns related to their muscles is thought facilitate how information processed circuits. Rabies retrograde monosynaptic tracing has been used label innervating specific...
Within the cervical and lumbar spinal enlargements, central pattern generating (CPG) circuitry produces rhythmic output necessary for limb coordination during locomotion. Long propriospinal neurons that inter-connect these CPGs are thought to secure hindlimb-forelimb coordination, ensuring diagonal pairs move synchronously while ipsilateral out-of-phase stepping. Here, we show silencing long ascending (LAPNs) interconnect disrupts left-right coupling at each girdle. These perturbations...
Abstract Long ascending propriospinal neurons (LAPNs) are a subpopulation of spinal cord interneurons that directly connect the lumbar and cervical enlargements. In uninjured animals, conditionally silencing LAPNs resulted in disrupted left-right coordination hindlimbs forelimbs context-dependent manner, demonstrating secure alternation fore- hindlimb pairs during overground stepping adult rat. Given their ventrolateral location white matter, many LAPN axons likely remain intact following...
Summary Dystonia, a neurological disorder defined by abnormal postures and disorganised movements, is considered to be neural circuit with dysfunction arising within between multiple brain regions. Given that spinal circuits constitute the final pathway for motor control, we sought determine their contribution movement disorder. Focusing on most common inherited dystonia, DYT1- TOR1A , confined conditional knockout of Tor1a cord dorsal root ganglia (DRG) found these mice recapitulated...