A5032764346- Biochemical and Molecular Research
- HIV/AIDS drug development and treatment
- SARS-CoV-2 and COVID-19 Research
- RNA modifications and cancer
- Mosquito-borne diseases and control
- Synthesis and biological activity
- Congenital Diaphragmatic Hernia Studies
- Congenital Anomalies and Fetal Surgery
- Prostate Cancer Treatment and Research
- Protein Degradation and Inhibitors
- Cytomegalovirus and herpesvirus research
- Radiopharmaceutical Chemistry and Applications
- Neonatal Health and Biochemistry
- Click Chemistry and Applications
- Respiratory viral infections research
- Influenza Virus Research Studies
- Computational Drug Discovery Methods
- Congenital Heart Disease Studies
- Plant Virus Research Studies
- Bone health and treatments
Accademia Albertina delle Belle Arti
2023-2024
University of Turin
2019-2023
A panel of novel cinnamic ester derivatives showed a potent inhibitory effect against SARS-CoV-2 M pro and efficiently impaired the in vitro replication two human coronaviruses low micromolar range.
Although coronaviruses (CoVs) have long been predicted to cause zoonotic diseases and pandemics with high probability, the lack of effective anti-pan-CoVs drugs rapidly usable against emerging SARS-CoV-2 actually prevented a promptly therapeutic intervention for COVID-19. Development host-targeting antivirals could be an alternative strategy control CoVs infections, as they quickly repositioned from one pandemic event another. To contribute these preparedness efforts, here we report on...
The pharmacological management of influenza virus (IV) infections still poses a series challenges due to the limited anti-IV drug arsenal. Therefore, development new anti-influenza agents effective against antigenically different IVs is therefore an urgent priority. To meet this need, host-targeting antivirals (HTAs) can be evaluated as alternative or complementary approach current direct-acting (DAAs) for therapy IV infections. As contribution antiviral strategy, in study, we characterized...
SARS-CoV-2 Mpro is a chymotrypsin-like cysteine protease playing relevant role during the replication and infectivity of SARS-CoV-2, coronavirus responsible for COVID-19. The binding site characterized by presence catalytic Cys145 which carries out hydrolytic activity enzyme. As consequence, several inhibitors have been proposed to date in order fight COVID-19 pandemic. In our work, we designed, synthesized biologically evaluated MPD112, novel inhibitor bearing trifluoromethyl diazirine...
Human respiratory syncytial virus (RSV) is an important cause of acute lower infections, for which no effective drugs are currently available. The development new anti-RSV agents therefore urgent priority, and Host-Targeting Antivirals (HTAs) can be considered to target RSV infections. As a contribution this antiviral avenue, we have characterized the molecular mechanisms activity MEDS433, inhibitor human dihydroorotate dehydrogenase (hDHODH), key cellular enzyme de novo pyrimidine...
The appearance of new respiratory virus infections in humans with epidemic or pandemic potential has underscored the urgent need for effective broad-spectrum antivirals (BSAs). Bioactive compounds derived from plants may provide a natural source BSA candidates. Here, we investigated novel phytocomplex formulation SP4™ as candidate direct-acting against major current human viruses, including coronaviruses and influenza viruses. inhibited vitro replication SARS-CoV-2, hCoV-OC43, hCoV-229E,...
Prostate cancer (PCa) is the most frequent genitourinary tumour and third specific death cause, mostly because of bone metastasis. Currently, PCa treated with GnRH analogues (leuprolide acetate-LA) bisphosphonates (zoledronic acid-ZA) often in association. Thus, aim this work has been to study, vitro, effects these drugs on cell line derived from (DU-145). Particularly, we focused some crucial aspects that might play tumor evolution metastatization, by interfering vitality, migration...