A5086170635- Retinal Development and Disorders
- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Connexins and lens biology
- Nicotinic Acetylcholine Receptors Study
- Memory and Neural Mechanisms
- Medical Imaging and Analysis
- Cognitive Functions and Memory
- Artificial Intelligence in Healthcare and Education
- Dental Radiography and Imaging
- Memory Processes and Influences
University of California, Berkeley
2023-2024
Chandigarh University
2024
Carl von Ossietzky Universität Oldenburg
2017-2021
AII amacrine cells are essential interneurons of the primary rod pathway and transmit rod-driven signals to ON cone bipolar enable scotopic vision. Gap junctions made connexin36 (Cx36) mediate electrical coupling among between cells. These gap underlie a remarkable degree plasticity modulated by different signaling cascades. In particular, Ca2+/calmodulin-dependent protein kinase II (CaMKII) has been characterized as an important regulator Cx36, capable potentiating in However, it is unclear...
Abstract Bipolar cells of the retina carry visual information from photoreceptors in outer to retinal ganglion (RGCs) inner retina. express L-type voltage-gated Ca 2+ channels at synaptic terminal, but generally lack other types capable regenerative activity. As a result, flow along bipolar cell processes is passive nature, with no opportunity for signal boost or amplification way. Here we report surprising discovery that blocking Na + profoundly reduces output one class cell, type 6 ON...
In the mammalian retina, amacrine cells represent most diverse cell class and are involved in spatio-temporal processing of visual signals inner plexiform layer. They connected to bipolar, other ganglion cells, forming complex networks via electrical chemical synapses. The small-field A8 was shown receive non-selective glutamatergic input from OFF ON cone bipolar at its bistratified dendrites sublamina 1 4 Interestingly, it also form synapses with thus resembling rod pathway-specific AII...
Neuronal gap junctions formed by connexin36 (Cx36) and chemical synapses share striking similarities in terms of plasticity. Ca2+/calmodulin-dependent protein kinase II (CaMKII), an enzyme known to induce memory formation at synapses, has recently been described potentiate electrical coupling the retina several other brain areas via phosphorylation Cx36. The contribution individual CaMKII isoforms this process, however, remains unknown. We identified CaMKII-β mouse retina. Now, we set out...
Millions of individuals all around the world suffer from bone fractures each year. Bone must be quickly and accurately identified in order to receive appropriate diagnosis care. Every day, new, developing technologies, notably medical field, are emerging. However, there also certain antiquated techniques that still frequently employed productive. Automated fracture systems have grown popularity as a result improvements imaging technology. One these is identify broken bones using X-rays....
In retinitis pigmentosa (RP), rod and cone photoreceptors degenerate, depriving downstream neurons of light-sensitive input, leading to vision impairment or blindness. Although survive, some undergo morphological physiological remodeling. Bipolar cells (BCs) link photoreceptors, which sense light, retinal ganglion (RGCs), send information the brain. While photoreceptor loss disrupts input synapses BCs, whether BC output remodel has remained unknown. Here we report that synaptic from BCs...
Abstract In the outer plexiform layer (OPL) of mouse retina, two types cone photoreceptors (cones) provide input to more than a dozen bipolar cells (CBCs). This transmission is modulated by single horizontal cell (HC) type, only interneuron in retina. Horizontal form feedback synapses with cones and feedforward CBCs. However, exact computational role HCs still debated. Along performing global signaling within their laterally coupled network, also local, cone-specific feedback. Specifically,...
Abstract In retinitis pigmentosa (RP), rod and cone photoreceptors degenerate, depriving downstream neurons of light-sensitive input, leading to vision impairment or blindness. Although survive, some undergo morphological physiological remodeling. Bipolar cells (BCs) link photoreceptors, which sense light, retinal ganglion (RGCs), send information the brain. While photoreceptor loss disrupts input synapses BCs, whether BC output remodel has remained unknown. Here we report that synaptic from...