A5089524521- Immunodeficiency and Autoimmune Disorders
- Blood disorders and treatments
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Cystic Fibrosis Research Advances
- Paraoxonase enzyme and polymorphisms
- Platelet Disorders and Treatments
- Cytomegalovirus and herpesvirus research
- Monoclonal and Polyclonal Antibodies Research
- Pediatric health and respiratory diseases
- Mycobacterium research and diagnosis
- Neonatal Respiratory Health Research
- Systemic Lupus Erythematosus Research
- Cynara cardunculus studies
- Tuberculosis Research and Epidemiology
- Oral Health Pathology and Treatment
- Neutropenia and Cancer Infections
- Oral microbiology and periodontitis research
- Autoimmune and Inflammatory Disorders Research
- Biochemical Acid Research Studies
- Nerve injury and regeneration
- Celiac Disease Research and Management
- Optimism, Hope, and Well-being
- Salivary Gland Disorders and Functions
- Respiratory viral infections research
Ege University
2014-2024
Sivas State Hospital
2018
Malatya Devlet Hastanesi
2018
Common variable immunodeficiency (CVID) is a heterogeneous group of primary antibody deficiencies characterized by decreased serum immunoglobulin G along with decrease in IgA and/or IgM, defective specific production, and recurrent bacterial infections. Abnormal lymphocyte trafficking, dysregulated cellular responses to chemokines, uncontrolled T cell polarization may be involved the pathogenesis help understand clinical complications. We evaluated helper subsets (chemokine receptors CCR4,...
Chronic Mucocutaneous Candidiasis (CMC) is the chronic, recurrent, noninvasive Candida infections of skin, mucous membranes, and nails. A 26-month-old girl was admitted with complaints recurrent oral Candidiasis, diarrhea, respiratory infections. albicans grew in mucosa swab. CMV EBV DNA titers were elevated. She had hypergammaglobulinemia; IgE level, percentages lymphocyte subgroups, vitro T-cell proliferation responses normal. parenchymal nodules within lungs a calcific nodule liver....
Chronic granulomatous disease (CGD) is a primary immunodeficiency characterized by susceptibility to bacterial and fungal infections resulting from the inadequacy of phagocytic leucocytes produce reactive oxygen radicals. CGD genetically heterogeneous with an X-linked recessive (XR-CGD) form caused mutations in CYBB (OMIM #300481) gene encoding gp91(phox) protein, autosomal (AR-CGD) CYBA #608508), NCF1 #608512), NCF2 #608515) NCF4 #601488) genes p22(phox), p47(phox), p67(phox) p40(phox),...
Defective adaptive immune responses are well studied in common variable immunodeficiency (CVID) patients; however, more focus is needed on innate system defects to explain CVID's clinical and laboratory heterogeneity. This the first study comparing migratory function of granulocytes, oxidative burst activity phagocytic cells, surface integrin expressions neutrophils lymphocytes, natural killer (NK) cell numbers cytotoxic activity, T lymphocyte subsets such as CD8(+)CD28(+), CD4(+)CTLA-4(+)...
Common variable immunodeficiency (CVID) and immunoglobulin A deficiency (IgAD) are the most prevalent primary disorders. High rates of familial inheritance have been described in CVID IgAD, but it is unknown different ethnic populations. We aimed to determine prevalence cases whether they showed more severe clinical characteristics than sporadic ones Turkish patients. total 40 70 IgAD patients their 251 first-degree relatives (FDRs) were evaluated. Demographic, clinical, laboratory data...
LPS-responsive beige-like anchor (LRBA) protein deficiency is a disease of immune dysregulation with autoimmunity affecting various systems.Two male siblings novel LRBA mutation had different primary findings at admission: the younger sibling chronic early-onset diarrhoea and elder one autoimmune haemolytic anaemia. During long-term follow-up for IPEX phenotype, both developed hypogammaglobulinaemia, enteropathy lung involvement. The patients partially responded to immunosuppressive...
Transient hypogammaglobulinemia of infancy (THI) is characterized by recurrent infections and one or more reduced serum immunoglobulin levels. Typically, THI patients recover spontaneously, mostly within 30-40 months age, but sometimes recovery may be delayed until 5-6 years age. The use intravenous (IVIg) as an alternative to antibiotic prophylaxis remains contraversial also in symptomatic patients. In fact, some authors believe that IVIg therapy cause a delay the maturation humoral immune...
Despite improvements in diagnosis and treatment, infections are still a major cause of morbidity mortality children with febrile neutropenia.In the majority episodes, source infection cannot be defined.In this study, we aimed to identify earlier predictors bacteremia/fungemia useful cytokine discriminate patients culture-confirmed bacterial/fungal infection.The most sensitive was interleukin (IL)-10 specific IL-8 predicting cases.IL-8 had greater sensitivity specificity determination...
Background Functional studies besides routine laboratory tests for the definitive diagnosis of T lymphocyte disorders with isolated or combined T/B‐cell immunodeficiencies are important. We hereby summarized our experience a carboxyfluorescein diacetate succinimidyl ester ( CFSE )‐based assay assessment mitogenic T‐cell proliferation responses in primary immunodeficiency PID ) patients who have not been diagnosed yet genetically analyzed, but classified as probably having defects. Methods...
Background Common variable immunodeficiency is a rare clinically symptomatic primary disorder which manifests wide variability of symptoms, complications. Atherosclerosis in common patients has not been investigated yet contrary to other severe clinical We aimed investigate the chitotriosidase enzyme's role as an inflammation and atherosclerosis marker paediatric patients. Methods (n = 24) healthy controls 23) evaluated for activity with markers (hsCRP, myeloperoxidase, serum amyloid A,...
Purine nucleoside phosphorylase deficiency is one of the severe combined immunodeficiencies, which often clinically manifests with recurrent infections, neurologic symptoms and autoimmune diseases, leads to thymocyte development peripheral T cell activation defects. It an immunologic emergency for childhood. In this case series, four cases purine were evaluated. Recurrent febrile infections neuromotor developmental retardation among presenting in all cases. Absolute lymphocyte counts serum...
Background Inflammation and hypercholesterolaemia contribute to atherosclerotic changes which can start in childhood. Children with hyperlipidaemias are at high risk for early coronary atherosclerosis. This study evaluates the relationship between lipoprotein-associated phospholipase A2 (Lp-PLA2), carotid intima-media thickness (CIMT) flow-mediated dilatation hypercholesterolaemic dyslipidaemic children. Methods We performed a case-control consisting of 43 cases, aged 2 17 years, 24...
Myocardial ischaemia in cardiac syndrome X (CSX) is believed to be due microvascular dysfunction. Increased oxidative stress one of the suspected mechanisms The aim this study was evaluate status patients with CSX, by determining serum paraoxonase-1 (PON 1) activity addition LDL-oxidation markers.This cross-sectional consisted CSX (group I, n = 30), coronary artery disease II, 31), and healthy controls III, 32). Lipid parameters, PON-1 activity, LDL oxidation markers (conjugated-diene...
Detection of antinuclear antibodies (ANA) is a diagnostic adjunct in patients with suspected autoimmune connective tissue diseases, and various detection methods are use. The aim this study was to analyze the agreement between ANA immunoflourescence (IF) immunoblotting (IB) determine cut-off for children subjects laboratory setting. We evaluated 729 serum samples that were analyzed by both IF IB. results chi(2) test and, agreement, kappa index used. Frequencies determined 1:40-1:100 titers...
Patients with some inflammatory diseases have been shown to increased levels of immunoglobulin light chains. In this study, we measured the concentrations kappa and lambda chains in sera patients juvenile idiopathic arthritis (JIA) (study group), familial mediterranean fever (FMF) (disease control group) healthy children. Our aim was compare chain other well-known markers inflammation, such as erythrocyte sedimentation rate (ESR) acute phase reactants (APRs), serum amyloid A (SAA) C-reactive...
In order to evaluate B-lymphocyte subsets of patients with primary immunodeficiencies, the normal values for national healthy children have be used as a reference. Recently, B-cell co-receptor markers (CD19, CD21, and CD81) CD20, CD22, CD27 deficiencies been reported in relation different immunodeficiency diseases. The objective this study was establish reference co-receptors some surface markers, CD27, well classic lymphocyte peripheral blood children. A total 90 were included study....