A5004212008- Genomics and Phylogenetic Studies
- Biochemical and Structural Characterization
- Gut microbiota and health
- Cellular Mechanics and Interactions
- Immune Cell Function and Interaction
- Cell Adhesion Molecules Research
- CAR-T cell therapy research
- Cardiomyopathy and Myosin Studies
- Microbial Community Ecology and Physiology
- Monoclonal and Polyclonal Antibodies Research
- Enzyme Production and Characterization
- Bacterial biofilms and quorum sensing
- Machine Learning in Bioinformatics
- Microtubule and mitosis dynamics
- Winter Sports Injuries and Performance
- Advanced Fluorescence Microscopy Techniques
- Viral Infectious Diseases and Gene Expression in Insects
- Oral microbiology and periodontitis research
- Probiotics and Fermented Foods
- Immunotherapy and Immune Responses
- Gene expression and cancer classification
- Protein Structure and Dynamics
- Antimicrobial Resistance in Staphylococcus
- Algorithms and Data Compression
University of California, San Francisco
2021-2022
Parker Institute for Cancer Immunotherapy
2021-2022
University of California, Berkeley
2016-2019
Berkeley College
2016
Chimeric antigen receptors (CARs) repurpose natural signaling components to retarget T cells refractory cancers but have shown limited efficacy in persistent, recurrent malignancies. Here, we introduce “CAR Pooling,” a multiplexed approach rapidly identify CAR designs with clinical potential. Forty CARs domains derived from range of immune cell lineages were evaluated pooled assays for their ability stimulate critical effector functions during repetitive stimulation that mimics long-term...
Microbial communities play important roles in the function and maintenance of various biosystems, ranging from human body to environment. A major challenge microbiome research is classification microbial different environments or host phenotypes. The most common cost-effective approach for such studies date 16S rRNA gene sequencing. Recent falls sequencing costs have increased demand simple, efficient accurate methods rapid detection diagnosis with proved applications medicine, agriculture...
Bacterial adhesion to collagen, the most abundant protein in humans, is a critical step initiation and persistence of numerous bacterial infections. In this study, we explore collagen binding mechanism multi-modular cell wall anchored adhesin (CNA) Staphylococcus aureus examine how applied mechanical forces can modulate ability. The common structural-functional elements domain organization CNA are present across over 50 genera bacteria. Through use molecular dynamics models normal mode...
Motivation: Microbial communities play important roles in the function and maintenance of various biosystems, ranging from human body to environment. A major challenge microbiome research is classification microbial different environments or host phenotypes. The most common cost-effective approach for such studies date 16S rRNA gene sequencing. Recent falls sequencing costs have increased demand simple, efficient, accurate methods rapid detection diagnosis with proved applications medicine,...
SUMMARY Chimeric antigen receptors (CARs) repurpose natural signaling components to retarget T cells refractory cancers, but have shown limited efficacy against solid tumors. Here, we introduce ‘CAR Pooling’, a multiplexed approach rapidly identify CAR designs with clinical potential. Forty CARs diverse immune costimulatory domains were assessed in pooled assays for their ability stimulate critical cell effector functions during repetitive stimulation that mimics long-term tumor exposure....
Microbial communities play important roles in the function and maintenance of various biosystems, ranging from human body to environment. Current methods for analysis microbial are typically based on taxonomic phylogenetic alignment using 16S rRNA metagenomic or Whole Genome Sequencing data. In typical characterizations communities, studies deal with billions micobial sequences, aligning them a tree. We introduce new approach efficient communities. Our reference-free tech- nique is n-gram...
Abstract Integrins αVβ3 and α5β1 play critical roles in tumor survival, invasion, metastasis, angiogenesis are validated targets for cancer therapy molecular imaging. Increasing evidence suggests that targeting both integrins simultaneously with antagonists is more effective because of concerns about resistance paradoxical promotion growth use agents highly selective a single integrin. Engineered Arg-Gly-Asp (RGD)-containing 3.5 kDa cysteine-knot proteins (knottins 2.5F 2.5D) attractive drug...