A5083873105- Immunotherapy and Immune Responses
- Tuberculosis Research and Epidemiology
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immune responses and vaccinations
- Immunodeficiency and Autoimmune Disorders
- Psoriasis: Treatment and Pathogenesis
- Ocular Surface and Contact Lens
- Immune cells in cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer Immunotherapy and Biomarkers
- Transgenic Plants and Applications
- Escherichia coli research studies
- Glycosylation and Glycoproteins Research
- Corneal Surgery and Treatments
- Bacteriophages and microbial interactions
- Mycobacterium research and diagnosis
- vaccines and immunoinformatics approaches
- IL-33, ST2, and ILC Pathways
- NF-κB Signaling Pathways
- Atherosclerosis and Cardiovascular Diseases
- Immune Response and Inflammation
Peter Doherty Institute
2021-2022
The University of Melbourne
2021-2022
University of Otago
2018-2021
The eye is considered immune privileged such that responses are dampened to protect vision. As the most anterior compartment of eye, cornea exposed pathogens and can mount recruit effector T cells. However, presence memory in not defined. Here, we use intravital 2-photon microscopy examine cell mice. We show recruitment CD8+ cells response ocular virus infection results formation tissue-resident (TRM) Motile corneal TRM patrol rapidly respond situ antigen rechallenge. CD103+ generation...
The tuberculosis (TB) vaccine bacille Calmette-Guérin (BCG) prevents disseminated childhood TB; however, it fails to protect against the more prevalent pulmonary TB. Limited understanding of immune response Mycobacterium tuberculosis, causative agent TB, has hindered development improved vaccines. Although memory CD4 T cells are considered main mediators protection recent studies suggest there other key subsets that contribute antimycobacterial immunity. To end, innate may be involved in...
A major obstacle to tuberculosis (TB)-subunit–vaccine development has been the induction of inadequate levels protective immunity due limited breadth antigen in vaccine preparations. In this study, immunogenic mycobacterial fusion peptides Ag85B-TB10.4 and Ag85B-TB10.4-Rv2660c were covalently displayed on surface self-assembled polyester particles. This study investigated whether particles displaying antigens could provide augmented immunogenicity (i.e., offer an innovative formulation) when...
Currently available vaccines fail to provide consistent protection against tuberculosis (TB). New, improved are urgently needed for controlling the disease. The mycobacterial antigen fusions H4 (Ag85B-TB10.4) and H28 (Ag85B-TB10.4-Rv2660c) have been shown be very immunogenic considered as potential candidates TB vaccine development. However, soluble protein often poorly immunogenic, but augmented immune responses can induced when selected antigens delivered in particulate form. This study...
Abstract Synthetic subunit vaccines hold great promise to prevent infectious diseases, but they often induce only weak immune responses. Here bioengineering techniques develop immunogenic antigen particles comprised of self‐assembling antigenic peptides are exploited. A bioparticle platform is developed present repetitive copies antigens, which mimic the host‐pathogen surface interaction provide enhanced immunogenicity. Herein, mycobacterial fusion proteins H4 (consisting Ag88B‐TB10.4) and...
Mycobacterium tuberculosis (Mtb) remains a global epidemic despite the widespread use of Bacillus Calmette-Guérin (BCG). Consequently, novel vaccines are required to facilitate reduction in Mtb morbidity and mortality. PilVax is peptide delivery strategy for generation highly specific mucosal immune responses based on food-grade bacterium Lactococcus lactis that used express selected peptides engineered within Streptococcus pyogenes M1T1 pilus, allowing amplification, stabilization enhanced...
Lung infection by Mycobacterium tuberculosis is characterized chronic of lung-resident macrophages, long considered to be the primary hosts and determinants outcome early immune response. Although alveolar macrophages are well-known host intracellular mycobacteria at later stages disease, little known about earliest events innate The phagocytes that take up immediately following infection, how lung phagocyte response altered vaccination with M. bovis bacille Calmette-Guérin (BCG) were...
In article number 1800118, Bernd H. A. Rehm and co-workers show how bioengineering of mycobacterial antigens enhances their intermolecular interactions that mediate self-assembly discrete antigen particles, inside a safe bacterial cell factory, Escherichia coli. The resulting pure particles induce strong antigen-specific humoral cell-mediated immune responses. This innovative approach enables rapid development custom-made particulate vaccines with augmented immunological properties toward...