A5058211797- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Primate Behavior and Ecology
- Human-Animal Interaction Studies
- Metabolomics and Mass Spectrometry Studies
- Mitochondrial Function and Pathology
- Peptidase Inhibition and Analysis
- Crystallography and molecular interactions
- Animal Behavior and Reproduction
- Animal Vocal Communication and Behavior
- Chemical Synthesis and Analysis
- Bat Biology and Ecology Studies
- Click Chemistry and Applications
University of Lisbon
2020-2022
The design of novel pharmaceutical multicomponent crystal forms has been reported as an efficient approach to tailor their physicochemical properties, including solubility. Sparfloxacin is a fluoroquinolone antibiotic widely used mainly in respiratory tract infections, but its safety profile controversial due photosensitivity reactions, and therefore the development alternative that may contribute intake lower dosages desirable. Herein we report five molecular salts sparfloxacin with...
Abstract Effective population size ( N e ) is a key concept in evolutionary and conservation biology. The western chimpanzee Pan troglodytes verus Critically Endangered taxon. In Guinea-Bissau, chimpanzees are mainly threatened by habitat loss, hunting diseases. Guinea-Bissau considered area for its conservation. Genetic tools have not yet been applied to inform management no estimates of obtained. this study, we use country’s range-wide microsatellite data five whole-genome sequences...
<title>Abstract</title> Campbell’s (<italic>Cercopithecus campbelli</italic>) and green monkeys (<italic>Chlorocebus sabaeus</italic>) are sympatric medium-sized West African guenons (tribe Cercopithecini) that generally understudied in most of their distribution. Both species ecological generalists globally considered non-threatened, but populations decreasing locally. National conservation management lacks baseline information on local primate species. <italic>C. campbelli Chl....
The site-selective chemical appendage of multiple functionalities on a native peptide backbone is highly demanding and complex tool modern biology. Here, novel NHS-activated acrylates were designed to hold various payloads in single bioconjugation handle that able site-selectively orthogonally target the N-terminal cysteine peptides.
Understanding how small populations cope with loss of genetic diversity and deleterious variation is crucial to address the current biodiversity crisis. Insular are particularly interesting as they have often persisted at low population sizes higher inbreeding than their mainland counterparts. While genome-wide consequences in threatened insular species received some attention, comparative genomics between wide-spread genetically diverse rarely been performed. Yet, well suited inform about...
Abstract The lesser spot-nosed monkey ( Cercopithecus petaurista ) is a widely distributed West African guenon, which generally considered less vulnerable to local extinctions than many sympatric primate species. Guinea-Bissau harbours the westernmost populations of species, thought be very rare or even extinct on mainland, but have putative some islands Bijagós Archipelago. However, due lack regional studies, baseline information these insular missing. We collected data anthropogenic...