A5065052492- Virus-based gene therapy research
- Cancer Research and Treatments
- Bacteriophages and microbial interactions
- Orthopedic Infections and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Viral Infectious Diseases and Gene Expression in Insects
- Boron Compounds in Chemistry
- Radiopharmaceutical Chemistry and Applications
Siberian Branch of the Russian Academy of Sciences
2022-2024
Institute of Chemical Biology and Fundamental Medicine
2022-2024
Combination therapy is becoming an increasingly important treatment strategy because multi-drugs can maximize therapeutic effect and overcome potential mechanisms of drug resistance. A new albumin-based theranostic containing gemcitabine closo-dodecaborate analogue has been developed for combining boron neutron capture (BNCT) chemotheraphy. An exo-heterocyclic amino group was used to introduce closo-dodecaborate, a 5'-hydroxy tether maleimide moiety through acid-labile phosphamide linker....
Background . One of the promising methods treating tumors is virotherapy, which based on direct lysis cancer cells by a virus and virus-mediated antitumor immune response body. For recombinant vaccinia strain VVGMCSF-Lact, producing human GMCSF oncotoxic protein lactaptin, cytotoxic effects were shown in experiments vitro vivo, respectively, when using adhesive cultures U-87 MG glioblastoma cells. 3D are more relevant tumor model than models, as they fully reflect realistic scenario...
Bacteriophages, bacterial viruses, are currently being used as source of effective gene therapy tools for cancer. The aim this study was to develop targeted hybrid vectors based on filamentous phage M13, capable efficient and selective delivery transgenes into U-87 MG human glioblastoma cells.