A5072658099- Cystic Fibrosis Research Advances
- Diet and metabolism studies
- Metabolomics and Mass Spectrometry Studies
- Clinical Nutrition and Gastroenterology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inhalation and Respiratory Drug Delivery
- Oral microbiology and periodontitis research
- Antimicrobial Resistance in Staphylococcus
- Immune Cell Function and Interaction
- Tryptophan and brain disorders
- Metabolism and Genetic Disorders
- Gut microbiota and health
- Bacterial biofilms and quorum sensing
- Pediatric health and respiratory diseases
- Neonatal Respiratory Health Research
Columbia University
2023-2024
Pseudomonas aeruginosa is a common cause of pulmonary infection. As Gram-negative pathogen, it can initiate brisk and highly destructive inflammatory response; however, most hosts become tolerant to the bacterial burden, developing chronic Using murine model pneumonia, we demonstrate that this shift from inflammation disease tolerance promoted by ketogenesis. In response infection, ketone bodies are generated in liver circulate lungs where they impose selection for P. strains unable display...
Abstract Staphylococcus aureus is a pulmonary pathogen associated with substantial human morbidity and mortality. As vaccines targeting virulence determinants have failed to be protective in humans, other factors are likely involved pathogenesis. Here we analysed transcriptomic responses of clinical isolates S. from initial chronic infections. We observed upregulated collagenase proline transporter gene expression infection isolates. Metabolomics bronchiolar lavage fluid fibroblast...