A5028019435- HIV/AIDS drug development and treatment
- Chemical Synthesis and Analysis
- biodegradable polymer synthesis and properties
- Lignin and Wood Chemistry
- Epoxy Resin Curing Processes
- Gamma-ray bursts and supernovae
- Click Chemistry and Applications
- Ginkgo biloba and Cashew Applications
- Particle Accelerators and Free-Electron Lasers
- Polymer composites and self-healing
- Advanced biosensing and bioanalysis techniques
- Pneumocystis jirovecii pneumonia detection and treatment
- DNA and Nucleic Acid Chemistry
- Particle accelerators and beam dynamics
- Synthesis and properties of polymers
- HIV Research and Treatment
- RNA Interference and Gene Delivery
- Power Systems and Technologies
- Chemistry and Chemical Engineering
- Natural Fiber Reinforced Composites
- Astronomy and Astrophysical Research
- Environmental Monitoring and Data Management
- Synthetic Organic Chemistry Methods
- Polymer Foaming and Composites
- Electromagnetic wave absorption materials
AREA Science Park
2009-2023
University of Trieste
2003-2014
N2 Biomedical (United States)
2010
University of Basilicata
2009
This paper provides a bio-based polyurethane foam (PUR) solution, following cradle-to-factory approach. The design of rigid PURs, reinforced with sustainable fillers have gained remarkable attention in "green" construction sector. Their marked performances make them viable solution for synthetic counterparts' replacement. In this work, functionalized hemp fibers and silica powders were selected as reactive fillers, imparting multifunctional properties to the designed PURs. Hemp underwent...
Abstract Two different novolac resins, named Nov‐I and Nov‐II, containing an amount of unreacted cardanol 35 wt % 20 %, respectively, were synthesized by the condensation reaction paraformaldehyde using oxalic acid as catalyst. Cardanol is main constituent cashew nut shell liquid, a renewable natural resource. The cardanol‐based novolacs tested curing agents diglycidyl ether bisphenol A epoxy resin employing 2‐ethyl‐4‐methyl‐imidazole catalyst differential scanning calorimeter...
Nowadays, the chemical industry is looking for sustainable chemicals to synthesize nanocomposite bio-based polyurethane foams, PUs, with aim replace conventional petrochemical precursors. Some possibilities increase environmental sustainability in synthesis of PUs include use and additives derived from renewable sources (such as vegetable oils or biomass wastes), which comprise increasingly wider base raw materials. Generally, exhibit chemico-physical, mechanical functional properties, are...
Byproducts derived from the food industry are an interesting biomass to valorize as they cheap source, their generation does not compete with and feed production, utilization solves waste disposal issue. In this work, we focused on production of a series polyesters using cardanol-derived diol produced inedible shell cashew nuts. The synthesized polymers 100% biobased since diacid components structure (adipic acid succinic acid) can also be bio-derived monomers. Moreover, overall process is...
It is well known that the traditional synthetic polymers, such as Polyurethane foams, require raw materials are not fully sustainable and based on oil-feedstocks. For this reason, renewable resources biomass, polysaccharides proteins still recognized one of most promising approaches for substituting oil-based (mainly polyols). However, polyurethanes from sources exhibit poor physical functional performances. best technological solution production polyurethane obtained through a partial...
Benzoxazines are a class of phenolic compounds extensively studied in polymer science because their properties as fiber reinforcements, fire-retardants and curing agents. In this article is described solvent-less process, based on Mannich reaction involving primary amine an aldehyde, for the preparation new benzoxazines deriving from cardanol (a well known phenol obtained renewable organic resource harmful by-product cashew industry). Particular attention given to synthesis chemical...
The base-catalyzed hydroazidation of α'-amino α,β-unsaturated ketones with in situ generated hydrazoic acid was found to proceed high stereoselectivity favor the syn product. is controlled by configuration enone and syn/anti ratios up 7:1 were obtained secondary tertiary amines at low temperature. By this route diamino alcohol core HIV-PR inhibitors ritonavir lopinavir synthesized 37% yield from phenylalanine.
Abstract The aim of this work is the development composite pipes using renewable resources. pipes, manufactured by filament winding technology, were obtained an epoxy resin crosslinked with a cardanol based novolac as matrix and jute fibres reinforcement. Cardanol natural oil extracted from shell cashew ( Anacardium occidentale L.) nut. An amount materials higher than 50% weight was achieved in final composites. Tensile parallel plate compression tests carried out on pipes.
Peptidomimetic inhibitors of HIV-1 PR are still a key resource in the fight against AIDS. Here we describe synthesis and biological activity based on four novel dihydroxyethylene isosteres Phe-Pro Pro-Pro dipeptides. The isosteres, containing stereogenic centers, were synthesized high yield excellent stereoselectivity via cyclization epoxy amines derived from α-amino acids. assembled by coupling with suitable flanking groups screened recombinant HIV showing activities subnanomolar to...
An innovative procedure aimed to the production of orthogonally protected amino-derivatives high-molecular weight poly(ethylene glycol) (PEG) modified with linkers bearing differently reactive terminal amino groups is reported. This polymeric derivative represents a convenient, new soluble support particularly suitable as drug delivery system mixed molecules. Keywords: Poly(ethylene glycol), PEG, polymer, conjugates, peptide,
Abstract A procedure has been developed for the preparation of peptide‐PEG‐oligonucleotide conjugates: two sequences were synthesized at extremities same commercial high‐molecular‐weight polyethylene glycol (PEG) starting both from peptide as well oligonucleotide component. The PEG was modified its terminal hydroxyl functions with orthogonal protecting groups (DMT and Fmoc). selective removal those allowed synthesis chimeras following different, interchangeable strategies. Comparison final...
Nowadays, the chemical industry is looking for sustainable chemicals to synthesize nanocomposite bio-based polyurethane foams, PUs, with aim replace conventional petrochemical precursors. Some possibilities increase environmental sustainability in synthesis of PUs include use and additives derived from renewable sources (such as vegetable oils or biomass wastes) which comprise an increasing wider base raw materials. Generally, exhibit chemico-physical, mechanical functional properties are...
A new pseudopeptide epoxide inhibitor, designed for irreversible binding to HIV protease (HIV-PR), has been synthesized and characterized in solution the solid state. However, crystal structure of complex obtained by inhibitor–enzyme cocrystallization revealed that a minor isomer, with inverted configuration carbons, selected HIV-PR during crystallization. The structural characterization well-ordered pseudopeptide, inserted catalytic channel its group intact, provides deeper insights into...
Abstract The synthesis of a peptide-PEG-oligonucleotide chimera is compared when starting from the peptide or oligonucleotide sequence.
We have synthesized and evaluated a small set of dual action HIV-Protease inhibitors, consisting catalytic site reversible inhibitor conjugated with dimerization peptidic inhibitor, linked via suitable selective end-modified poly(ethylene glycol), in an effort to obtain synergistic effect improved biological behaviour more powerful pharmacological features, such as water solubility, cell permeability bioavailability. Keywords: Poly(ethylene HIV-PR mixed conjugates, permeability,...