A5079909037- RNA Research and Splicing
- Retinal Development and Disorders
- Fibroblast Growth Factor Research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Kruppel-like factors research
- Cancer Research and Treatment
- Cancer Cells and Metastasis
- Endoplasmic Reticulum Stress and Disease
- Cellular transport and secretion
- Cellular Mechanics and Interactions
University of Leeds
2022-2023
University of Sheffield
2018
The recruitment of signaling proteins into activated receptor tyrosine kinases (RTKs) to produce rapid, high-fidelity downstream response is exposed the ambiguity random diffusion target site. Liquid-liquid phase separation (LLPS) overcomes this by providing elevated, localized concentrations required while impeding competitor ligands. Here, we show a subset phosphorylation-dependent RTK-mediated LLPS states. We then investigate formation phase-separated droplets comprising ternary complex...
STX19 is an unusual Qa-SNARE as it lacks a C-terminal transmembrane domain. However, efficiently targeted to post-Golgi membranes. Here, we set out determine the intracellular localisation of endogenous and elucidate mechanism by which We have found that pool localised tubular recycling endosomes where colocalises with MICAL-L1 Rab8 (which has Rab8a Rab8b forms). Using combination genetic, biochemical cell-based approaches, identified S-acylated at its C-terminus substrate for several...
Abstract Triple-negative breast cancer (TNBC) is the most aggressive subtype of cancer, with worst prognosis and limited treatment options. TNBC cells undergo metabolic reprogramming in response to nutrient limitations changes tumor microenvironment throughout progression. In early stages, are found prioritize uptake biosynthesis, but as they grow, intensified competition for nutrients fosters emergence subpopulations that excel utilizing specific nutrients. The substantial pathways genes...
Abstract Metastatic Breast Cancer is accountable for over half a million deaths worldwide each year, the majority of which are from triple negative breast cancer (TNBC) subtype, known to be highly aggressive, metastatic and resistant targeted therapy. Metastasis driven by ability cells undergo epithelial mesenchymal transition (EMT), cell state involving gain stemness, motility chemoresistance. EMT has been well characterized using range techniques based upon quantitative proteomics...