A5046312567- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Cancer therapeutics and mechanisms
- Pneumocystis jirovecii pneumonia detection and treatment
- Advanced Battery Materials and Technologies
- Helicobacter pylori-related gastroenterology studies
- Nanomaterials for catalytic reactions
- Infectious Diseases and Mycology
- Antimicrobial Resistance in Staphylococcus
- Hedgehog Signaling Pathway Studies
- Advancements in Battery Materials
Baylor University Medical Center
2017-2019
Nanyang Technological University
2019
Levofloxacin is used for the treatment of multidrug-resistant tuberculosis; however optimal dose unknown.We hollow fiber system model tuberculosis (HFS-TB) to identify 0-24 hour area under concentration-time curve (AUC0-24) minimum inhibitory concentration (MIC) ratios associated with maximal microbial kill and suppression acquired drug resistance (ADR) Mycobacterium (Mtb). Levofloxacin-resistant isolates underwent whole-genome sequencing. Ten thousands patient Monte Carlo experiments (MCEs)...
Ceftazidime-avibactam is highly efficacious against extensive- and multidrug-resistant strains of Mycobacterium tuberculosis .
To determine if ceftaroline and ceftazidime combined with avibactam are efficacious against pulmonary Mycobacterium avium complex (MAC) disease.First, we performed a concentration-effect study of ceftaroline/avibactam extracellular MAC in test tubes. Given the difficulty obtaining at time experimentation, used single concentration commercial ceftazidime/avibactam, two sets non-treated controls, one ceftazidime/avibactam other without. After finding antimicrobial activity 'control',...
To determine if tedizolid is effective for pulmonary Mycobacterium avium complex (MAC) disease, and to use pharmacokinetics/pharmacodynamics design optimal doses. We performed an exposure–response experiment in the hollow-fibre system model of intracellular MAC (HFS-MAC). mimicked concentration–time profiles achieved lungs patients treated once daily 28 days. The HFS-MAC was sampled at intervals pharmacokinetics burden. identified 0–24 h area under curves MIC (AUC0–24/MIC) ratios associated...
ABSTRACT The modern chemotherapy era started with Fleming's discovery of benzylpenicillin. He demonstrated that benzylpenicillin did not kill Mycobacterium tuberculosis . In this study, we found >64 mg/liter static concentrations killed 1.16 to 1.43 log 10 CFU/ml below starting inoculum extracellular and intracellular M. over 7 days. When added the β-lactamase inhibitor avibactam, maximal ( E max ) log-phase-growth was 6.80 ± 0.45 at a 50% effective concentration (EC 50 15.11 2.31...
Ethionamide is used to treat multidrug-resistant tuberculosis (MDR-TB). The antimicrobial pharmacokinetics/pharmacodynamics, the contribution of ethionamide multidrug regimen, and events that lead acquired drug resistance (ADR) are unclear.We performed a multidose hollow fiber system model (HFS-TB) study identify 0-24 hour area under concentration-time curve (AUC0-24) minimum inhibitory concentration (MIC) ratios achieved maximal kill ADR suppression, defined as target exposures....
Linezolid exhibits remarkable sterilizing effect in tuberculosis; however, a large proportion of patients develop serious adverse events. The congener tedizolid could have better side-effect profile, but its potential is unknown.We performed 42-day exposure-effect and dose-fractionation study the hollow fiber system model tuberculosis for effect, using human-like intrapulmonary pharmacokinetics. Bacterial burden was examined time to positivity (TTP) colony-forming units (CFUs)....
To compare the efficacy of ceftazidime/avibactam plus tedizolid-based combination regimens with standard therapy azithromycin, ethambutol and rifabutin for treatment pulmonary Mycobacterium avium complex (MAC) disease.We mimicked human concentration-time profiles tedizolid in combination, ceftazidime/avibactam, rifabutin, moxifloxacin (CARTM), regimen examined microbial kill triplicate hollow-fibre system model intracellular MAC (HFS-MAC) units. The doses used were non-optimized; dose was...
Children are often neglected during early development of antituberculosis agents, and most receive treatment after it is first tested in adults. However, very young children have tuberculosis that differs many respects from adult cavitary pneumonia could different toxicity profiles to drugs. Linezolid effective against intracellular tuberculosis, a common manifestation children. linezolid has considerable due inhibition mitochondrial enzymes. Tedizolid be replacement if shows equal efficacy...
Drug-resistant tuberculosis represents a global emergency, requiring new drugs. We found that minocycline was highly potent in laboratory strains of Mycobacterium and 30 drug-susceptible multidrug/extensively drug-resistant clinical were susceptible to clinically achievable concentrations. In the hollow fiber system model, lung concentration-time profiles 7 mg/kg/day human-equivalent dose achieved bacterial kill rates equivalent those first-line antituberculosis agents. Minocycline killed...
Our aim was to identify the pharmacokinetic/pharmacodynamic parameters of minocycline in hollow-fibre system (HFS) model pulmonary Mycobacterium avium complex (MAC) and optimal clinical dose.Minocycline MICs for 55 MAC isolates from Netherlands were determined. We also co-incubated primary isolated macrophages infected with minocycline. Next, we performed a 28 day HFS-MAC dose-response study which mimicked concentration-time profiles achieved patients. The sampled at intervals determine...
MDR-TB and XDR-TB have poor outcomes. To examine the efficacy of tigecycline monotherapy in hollow fibre system model TB. We performed pharmacokinetic/pharmacodynamic studies using human-like concentration–time profiles TB five separate experiments Mycobacterium tuberculosis log-phase growth or as semi-dormant intracellular bacilli, monotherapy. also compared with isoniazid/rifampicin/pyrazinamide combination (standard therapy). then applied extinction mathematics, morphisms Latin hypercube...
Abstract The front cover artwork is provided by Pooi See Lee's group. image shows the hybrid Al‐Li‐ion batteries with Al as anode and mixed 3+ Li + ions based electrolyte. Owing to low cost, high volumetric capacities dendrite‐free characteristics of improved kinetics utilizing electrolytes, deliver competitive advantages among various energy storage devices. Read full text article at 10.1002/batt.201800108 .