A5075156758- MicroRNA in disease regulation
- Heat shock proteins research
- Extracellular vesicles in disease
- Cancer Cells and Metastasis
- Circular RNAs in diseases
- Immune cells in cancer
- Immune Cell Function and Interaction
- Petroleum Processing and Analysis
- Connexins and lens biology
- Cancer-related Molecular Pathways
- Nanoplatforms for cancer theranostics
- Fetal and Pediatric Neurological Disorders
- Inflammatory Biomarkers in Disease Prognosis
- Sepsis Diagnosis and Treatment
- Arsenic contamination and mitigation
- Vector-borne infectious diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- RNA Interference and Gene Delivery
- Circadian rhythm and melatonin
- Iron and Steelmaking Processes
- RNA modifications and cancer
- Chemokine receptors and signaling
- Ferroptosis and cancer prognosis
- Cancer Mechanisms and Therapy
- Hematological disorders and diagnostics
Jiangxi Provincial Academy of Medical Sciences
2025
Nanchang University
2025
The First Hospital of Changsha
2022-2024
Soochow University
2024
Beijing Hua Xin Hospital
2024
Central South University
2024
Xiamen University
2012-2021
First Affiliated Hospital of Zhengzhou University
2017
Abstract Gemcitabine (GEM) resistance affects chemotherapy efficacy of pancreatic cancer (PC). Cancer‐associated fibroblasts (CAFs) possess the ability regulating chemoresistance. This study probed mechanism hypoxia‐treated CAFs cell stemness and GEM in PC. Miapaca‐2/SW1990 were co‐cultured with PC‐derived under normoxic/hypoxic conditions. Cell viability/self‐renewal was determined by MTT/sphere formation assays, respectively. Protein levels CD44, CD133, Oct4, Sox2 western blot. tumoricidal...
Pancreatic cancer (PC) is a malignant tumor with high mortality worldwide. SIRT6 plays versatile roles in human cancers. However, has rarely been studied PC. The purpose of the present study was to explore function and potential mechanism expression PC tissues cells detected by reverse transcription-quantitative PCR western blotting. overall survival time analyzed through Kaplan Meier method. Cell viability measured Counting Kit-8 assay. Fe
Abstract Objective Thyroid cancer (TC) is one of the fastest‐growing malignant tumors. This study sought to explore mechanism immune escape mediated by receptor tyrosine kinase (KIT) in TC. Methods The expression microarray TC was acquired through GEO database, and difference analysis Kyoto encyclopedia genes genomes pathway enrichment were carried out. KIT levels cell lines (K1/SW579/BCPAP) human normal thyroid cells detected using reverse transcription quantitative polymerase chain...
Given the increasing incidence of pancreatic cancer and low survival rate, exploration complex tumor microenvironment development novel treatment options is urgent. NK cells, known for their cytotoxic abilities modulation other immune are vital in recognizing killing cells. However, hypoxic conditions have been found to impair cell functionality contribute escape. Therefore, we aimed uncover mechanism through which hypoxia mediates escape focusing on influence miR-1275/AXIN2 Using a...
Bone and bone marrow are the third most frequent sites of metastases from many cancers associated with low survival high morbidity rates. Currently, there no effective bedside tools to predict risk these patients in general intensive care units (ICUs). The main objective this study was establish validate a nomogram metastases.Data on were extracted Medical Information Mart for Intensive Care III (MIMIC-III) database. divided into training validation cohorts. data analyzed using univariate...
Background: Neonatal cerebral microbleeds (CMBs) occur infrequently, and during the initial phase, they often present without noticeable clinical symptoms, which can result in delays both diagnosis treatment. There has been relatively little research conducted on neonatal CMBs, with even less focus their related risk factors. However, identifying factors proactively preventing is particularly crucial for effective Therefore, we aimed to develop validate a nomogram based characteristics...
Abstract Purpose: Cx43 (connexin 43) has been found to inhibit cell cycle of tumor cells. No nuclear localization sequence was but the protein in nucleus. The process remains unclear. We are aiming at providing model that AKAP95 (A-kinase anchoring protein) binds and transports into nucleus lung cancer Methods: Lung cells were arrested preliminary stage (P), middle late (M) G1 phase restriction point (R). Immunocoprecipitation (Co-IP) Western blot (WB) used analyze expression binding AKAP95,...
Abstract Background: Arsenide, a kind of pollution widely existing in the environment, and mechanism occurrence development lung cancer leading by long-term arsenic exposure still needs further research up to present. We investigated how high low doses induce human bronchial epithelial cell transformation molecular mechanisms involved Methods: After exposing cells(Beas-2B) different sodium arsenite for 24 h, RNA-seq analysis was performed detect arsenic-regulated genes; viability status...