A5090024509- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- PI3K/AKT/mTOR signaling in cancer
- Nanoplatforms for cancer theranostics
- Brain Metastases and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Angiogenesis and VEGF in Cancer
- Meningioma and schwannoma management
- Epigenetics and DNA Methylation
- Cancer Mechanisms and Therapy
- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- Plant biochemistry and biosynthesis
- Cancer therapeutics and mechanisms
- Nanoparticle-Based Drug Delivery
- Cytokine Signaling Pathways and Interactions
- Immunotherapy and Immune Responses
- Pancreatic and Hepatic Oncology Research
- Bioactive Compounds and Antitumor Agents
- Curcumin's Biomedical Applications
- Nerve injury and regeneration
- Estrogen and related hormone effects
- Cancer, Lipids, and Metabolism
- Receptor Mechanisms and Signaling
Carol Davila University of Medicine and Pharmacy
2024-2025
University of Medicine and Pharmacy of Craiova
2015-2024
Hai phong University Of Medicine and Pharmacy
2024
Clinical Emergency Hospital Bucharest
2024
Laboratoire de Biochimie
2016
Karolinska University Hospital
1998-2009
Karolinska Institutet
1996-2007
Sophiahemmet Hospital
2006-2007
InDex Pharmaceuticals (Sweden)
1996
Depletion of mevalonic acid (MVA), obtained by inhibition 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase using lovastatin, depressed the biosynthesis dolichyl-phosphate and rate N-linked glycosylation caused growth arrest in melanoma cell line SK-MEL-2. The was partially prevented addition high concentrations insulin-like factor-1 (IGF-1) to cells, indicating that MVA depletion may inhibit through decreasing number IGF-1 receptors (IGF-1R) at surface. Such a decrease receptor...
Glioblastoma (GBM) is an aggressive brain tumor characterized by its molecular complexity and resistance to conventional treatments, including surgery, radiation, chemotherapy. Despite these challenges, advancements in receptor tyrosine kinase (RTK) research, combined with multi-omics approaches, hold promise for improving patient outcomes survivability. RTKs, are central GBM progression, influencing cell proliferation, survival, angiogenesis. However, the of RTK signaling necessitates a...
Introduction: This study aims to construct a predictive model that classifies the severity of coronavirus disease 2019 (COVID-19) in cancer patients by analyzing clinical, radiological, and demographic data. The goal is assist healthcare providers identifying high-risk ensuring optimal resource allocation. Materials methods: Data from 237 diagnosed with COVID-19 was utilized forecast based on various predictors. Key factors included type stage, intensive care unit admission, radiological...
Glioblastoma (GBM) is an aggressive brain tumor characterized by molecular complexity and resistance to conventional treatments, including surgery, radiation, chemotherapy. Despite these challenges, advancements in receptor tyrosine kinase (RTK) research, combined with multi-omics approaches, hold promise for improving patient outcomes survivability. RTKs are central GBM progression, influencing cell proliferation, survival, angiogenesis. However, the of RTK signaling necessitates a broader,...
One or more mevalonate derivatives of non-sterol type have been proposed to be indispensable importance for cell growth. Conceivable mevalonate-dependent mechanisms involved in growth control are farnesylation Ras proteins, regulation c-myc expression, and N-linked glycosylation the IGF-1 receptor. The latter mechanism might rate-limited by dolichyl phosphate, which acts as a donor oligosaccharides glycoprotein synthesis endoplasmic reticulum. In order study significance proliferation three...
SUMMARY Endometriosis is defined by the presence of tissue implants resembling endometrial glands outside uterus, at ectopic sites, frequently on ovarian surface. The lesions are often invasive, resistant to therapy, and may predispose endometrioid clear cell tumors. complex mechanisms leading chronic endometriosis mediated partly impaired immune surveillance in host. Although innate immunity has been addressed previously, response adaptive effectors specific antigens not characterized,...
Insulin-like growth factor-1 receptor (IGF-1R) has been shown to be important for melanoma cell and survival. In this study we first show, using immunohistochemistry, that progression from benign nevi malignant is paralleled by an increased expression of IGF-1R a down-regulation the cyclin-dependent kinase inhibitor p27Kip1. Even though p27Kip1 was drastically reduced compared tumors, detectable amounts it could assayed Western blotting in cultured cells. To analyze whether there causative...