A5101903789- Manufacturing Process and Optimization
- Blood Pressure and Hypertension Studies
- Aortic aneurysm repair treatments
- Nitric Oxide and Endothelin Effects
- Renin-Angiotensin System Studies
- Renal and Vascular Pathologies
- Abdominal vascular conditions and treatments
- Aortic Disease and Treatment Approaches
- Advanced Measurement and Metrology Techniques
- Acute Kidney Injury Research
- Cardiac, Anesthesia and Surgical Outcomes
- Cervical and Thoracic Myelopathy
- Mechanical Engineering and Vibrations Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Abdominal Trauma and Injuries
- Renal function and acid-base balance
- Gear and Bearing Dynamics Analysis
- MRI in cancer diagnosis
- Liver Disease Diagnosis and Treatment
- Topology Optimization in Engineering
- Spinal Fractures and Fixation Techniques
- Vascular Procedures and Complications
- Liver Disease and Transplantation
- Vasculitis and related conditions
- Industrial Vision Systems and Defect Detection
Mitsubishi Kyoto Hospital
2018-2025
Mazda Motor Corporation (Japan)
2017-2024
Hiroshima University
2021
Saiseikai Utsunomiya hospital
2003-2020
Gunma Chuo Hospital
2018
National Center of Neurology and Psychiatry
2017
University of Minnesota
2011-2014
Harvey Mudd College
2010
Keio University
1997-2005
St. Marianna University School of Medicine
2001-2003
The effects of 2 and 4 mo bed rest, with or without exercise countermeasures, on the contractile properties slow fibers in human soleus muscle were examined. Mean fiber diameters 8 36% smaller after respectively, than pre-bed rest level. Maximum tetanic force (P(o)), maximum activated (F(max)) per cross-sectional area (CSA), common-logarithm value free Ca(2+) concentration required for half-maximal activation (pCa(50)) also decreased rest. In contrast, unloaded shortening velocity (V(o)) was...
It has not been examined whether the pressure-natriuresis response is altered in insulin-resistant condition. Furthermore, despite an important role of nitric oxide (NO) modulating pressure-natriuresis, no investigations have conducted assessing renal interstitial NO production insulin resistance. The present study was obese Zucker rats (OZ) and assessed cortical medullary nitrate/nitrite (NOx) levels with use microdialysis technique. In OZ, serum insulin/glucose ratio (23.0+/-4.0x10(-8),...
The purpose of this study was to compare the usefulness ultrasonography that angiography for studying arterial lesions in Takayasu's arteritis. Ultrasonographic and angiographic findings from 44 carotid arteries 22 patients with arteritis (2 men 20 women; mean age, 41.2 years) were compared. Angiography used classify patency into three groups: nonstenotic, stenotic, occlusive. Ultrasonography also same four mildly moderately Thickness wall (intima-media complex) artery measured...
Objective To assess the in-vivo action on renal microvasculature of calcium antagonists nifedipine (L-type blocker), efonidipine (L/T-type and mibefradil (predominant T-type blocker). Design An intravital needle-type charge-coupled device (CCD) camera videomicroscope was introduced to visualize microcirculation directly in vivo. Methods In anesthetized mongrel dogs, (0.01–1 mg/kg per min), (0.033–0.33 or min) infused intravenously after insertion a CCD probe into kidney. Renal microvascular...
The present study was undertaken to clarify the role of intrarenal angiotensin (Ang) II and its generating pathways in clipped nonclipped kidneys 4-week unilateral renal artery stenosis anesthetized dogs. After 4 weeks, plasma flow (RPF) decreased (baseline, 59+/-3; clipped, 16+/-1; nonclipped, 44+/-2 mL/min; P<0.01, n=22). Renal Ang I levels increased only whereas contents were elevated both (from 0.7+/-0.1 2.0+/-0.2 pg/mg tissue) 0.6+/-0.1 2.5+/-0.3 tissue). Intrarenal ACE activity but...
Responses of the properties connectin molecules in slow-twitch soleus (Sol) and fast-twitch extensor digitorum longus muscles rats to 3 days unloading with or without 3-day reloading were investigated. The wet weight (relative body wt) Sol, not longus, unloaded group was significantly less than age-matched control (P < 0.05). Immunoelectron microscopic analyses showed that a monoclonal antibody against (SM1) bound I-band region close edge A band at resting length moved reversibly away from Z...
Abstract. The present study examined the role of intrarenal bradykinin in angiotensin-converting enzyme inhibitor (ACEI)-induced dilation renal afferent (AFF) and efferent arterioles (EFF) vivo, further evaluated whether ACEI-stimulated activity differed superficial (SP) juxtamedullary nephrons (JM). Arterioles canine kidneys were visualized with an intravital charge-coupled device camera microscope. E4177 (an angiotensin receptor antagonist, 30 μg/kg) dilated AFF EFF SP (15 ± 3% 19 5%) JM...
In six small renal angiomyolipomas (7-17 mm) the superiority of displaying CT numbers pixels within a lesion (pixel mapping) over usual region interest (ROI) measurement is described in detection amounts fat tissue. On precontrast 5 mm ROI measurements were > 0 four cases whereas pixel maps revealed with values < cases.
Although the angiotensin-converting enzyme (ACE) inhibitor-induced bradykinin enhances nitric oxide (NO) release, may also stimulate production of an additional vasodilator, endothelium-derived hyperpolarizing factor (EDHF). This study examined role EDHF in mediating NO-independent action ACE inhibitors canine renal microcirculation vivo. We used intravital CCD camera videomicroscopy that allowed direct visualization superficial and juxtamedullary nephrons vivo, situ, relatively intact...
Our goal was to describe the pulmonary parenchymal manifestations of Takayasu arteritis visualized on CT.We assessed CT findings for parenchyma in 25 patients with and compared them those by angiography (n = 20) radionuclide perfusion scintigraphy 19).A review scans revealed a total 33 low attenuation areas lung (11 patients), subpleural reticulolinear changes (12 pleural thickening (9 patients). The were preferentially seen corresponded angiographic staining scintigraphic defects. No...
In this study, the global fiber kinking theory proposed by Budiansky and Fleck for estimation of axial compressive strength unidirectional carbon reinforced plastic was modified localized problem. The deterministic mechanism kink-band width interpreted using a graphical method. Carbon manufactured from epoxy matrix prepreg autoclave technology, measured. nonlinear shear stress–strain curves composite were also measured V-notched beam, in-plane shear, torsion tests. estimated based on...
The role of nitric oxide (NO) and prostaglandins (PG) in modifying renal hemodynamics was examined clipped nonclipped kidneys unilateral artery stenosis. Chronic ischemia established by 4-wk-clipping the left canine kidneys, interstitial nitrate+nitrite PGE(2) contents were evaluated microdialysis technique. Unilateral stenosis caused 45 +/- 1 73 1% decrements plasma flow (RPF) moderately severely 21 3% with severe Renal decreased (-31 1%) (-63 4%). N(omega)-nitro-L-arginine methyl ester...
Although acute renal ischaemia alters the production of various paracrines, there has been little investigation examining role intrarenal vasoactive substances. In present study, we investigated nitric oxide and prostaglandins in modulating hypoperfusion-induced alterations function. After a 90% clipping left artery for 60 min, clip was released, haemodynamics sodium excretion were evaluated both clipped non-clipped kidneys anaesthetized dogs. Furthermore, changes contents nitrate/nitrite...