A5062742481- Genetic Associations and Epidemiology
- Turtle Biology and Conservation
- Epigenetics and DNA Methylation
- Clinical Reasoning and Diagnostic Skills
- Innovations in Medical Education
- Amphibian and Reptile Biology
- RNA Research and Splicing
- RNA modifications and cancer
- Venomous Animal Envenomation and Studies
- Molecular Biology Techniques and Applications
- Genetic Syndromes and Imprinting
- Meta-analysis and systematic reviews
- Parkinson's Disease Mechanisms and Treatments
- Genetics, Aging, and Longevity in Model Organisms
- Chemokine receptors and signaling
- Marine Invertebrate Physiology and Ecology
- Birth, Development, and Health
- Healthcare Operations and Scheduling Optimization
- Cardiac, Anesthesia and Surgical Outcomes
- Veterinary Equine Medical Research
- Head and Neck Surgical Oncology
- Bioinformatics and Genomic Networks
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Science, Research, and Medicine
- Neurological diseases and metabolism
University of Plymouth
2024
University of Florida
2017
WaterNSW
2006-2017
University of Gothenburg
2017
University of Maryland, Baltimore
1989-2016
Brunel University of London
2007
City University of Seattle
1989
Johns Hopkins University
1989
New York Eye and Ear Infirmary
1966
A fundamental challenge in the post-genome era is to understand and annotate consequences of genetic variation, particularly within context human tissues. We present a set integrated experiments that investigate effects common variability on DNA methylation mRNA expression four brain regions each from 150 individuals (600 samples total). find an abundance cis regulation show for first time abundant quantitative trait loci CpG across genome. peak enrichment QTLs be approximately 68,000 bp...
Antechinus are a genus of mouse-like marsupials that exhibit rare reproductive strategy known as semelparity and also naturally develop age-related neuropathologies similar to those in humans. We provide the first annotated antechinus reference genome for brown (Antechinus stuartii). The is 3.3 Gb size with scaffold N50 73Mb 93.3% complete mammalian BUSCOs. Using bioinformatic methods we assign scaffolds chromosomes identify 0.78 Mb Y-chromosome scaffolds. Comparative genomics revealed...
The effects of intramuscular (IM) alfaxalone were evaluated in three species Australian frogs: green tree frogs, (Litoria caerulea); and golden bell frogs aurea); booroolong booroolongensis). Heart rate, respiration responses, reflexes, spontaneous movement, time to effect, duration effect measured. Other observations, including change color pupil size, also noted. Alfaxalone administered IM at 30 mg/kg 20 achieved sedation caused bradypnea. In a light plane anesthesia bradypnea occurred IM....
NPT520-34 is a clinical stage, small molecule being developed for the treatment of Parkinson's disease and other neurodegenerative disorders. The therapeutic potential was first suggested by findings from cell-based assays alpha-synuclein clearance. As reported here, subsequently evaluated therapeutically relevant actions in transgenic animal model that overexpresses human an acute lipopolysaccharide-challenge using wild-type mice. Daily administration to mThy1-alpha-synuclein (Line 61) mice...
Aim: This is Article 2 of a three-part series on clinical reasoning that encourages practitioners to explore and understand how they think make case-based decisions. It hoped that, in the process, will learn trust their intuition but, at same time, put place safeguards diminish impact bias misguided logic diagnostic decision-making. Series outline: 1, published January 2016 issue JFMS, discussed relative merits shortcomings System 1 thinking (immediate unconscious) (effortful analytical)....
Aim: This is Article 1 of a three-part series on clinical reasoning that encourages practitioners to explore and understand how they think make case-based decisions. It hoped that, in the process, will learn trust their intuition but, at same time, put place safeguards diminish impact bias misguided logic diagnostic decision-making. Series outline: first article discusses relative merits shortcomings System thinking (immediate unconscious) 2 (effortful analytical). Articles 3, appear March...
This is Article 3 of a three-part series on clinical reasoning that encourages practitioners to explore and understand how they think make case-based decisions. It hoped that, in the process, will learn trust their intuition but, at same time, put place safeguards diminish impact bias misguided logic diagnostic decision-making.
Summary We apply transcriptome-wide RNA sequencing in postmortem autism spectrum disorder (ASD) brain and controls identify convergent alterations the noncoding transcriptome, including primate specific lncRNA, transcript splicing ASD cerebral cortex, but not cerebellum. characterize an attenuation of patterning between frontal temporal cortex SOX5 , a transcription factor involved cortical neuron fate specification, as likely driver this pattern. further show that genetically defined...
Abstract Capability is the ability to perform clinical skills in ever‐changing real world contexts, adapting challenges and integrating technical non‐technical competencies, for example, cannulating an uncooperative patient at night. Going beyond teaching competency ensuring capability imperative, as recommended by national outcomes medical graduates. A course on intravenous cannulation was developed with e‐learning modules high‐fidelity complex simulation scenarios, aiming promote practice....
WHIM (Warts, Hypogammaglobulinemia, Infections, and Myelokathexis) syndrome is an ultra-rare, combined primary immunodeficiency chronic neutropenic disorder characterized by a range of clinical presentations, including peripheral neutropenia, lymphopenia, recurrent infections. most often caused gain-of-function mutations in the gene encoding C-X-C chemokine receptor 4 (CXCR4). As such, inhibition CXCR4 with XOLREMDI
Abstract Antechinus are a genus of mouse-like marsupials that exhibit rare reproductive strategy known as semelparity and also naturally develop age-related neuropathologies similar to those in humans. We provide the first annotated antechinus reference genome for brown ( stuartii ). The is 3.3Gb size with scaffold N50 73Mb 93.3% complete mammalian BUSCOs. Using bioinformatic methods we assign scaffolds chromosomes identify 0.78Mb Y-chromosome scaffolds. Comparative genomics revealed...