A5084847068- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Chromosomal and Genetic Variations
- Genomics and Chromatin Dynamics
- Genomics and Phylogenetic Studies
- RNA modifications and cancer
- Yersinia bacterium, plague, ectoparasites research
- Forensic and Genetic Research
- Neurotransmitter Receptor Influence on Behavior
- Forensic Anthropology and Bioarchaeology Studies
- Genetics, Bioinformatics, and Biomedical Research
- Neurobiology and Insect Physiology Research
- Tryptophan and brain disorders
- Bioinformatics and Genomic Networks
- Receptor Mechanisms and Signaling
- Stress Responses and Cortisol
- Adipose Tissue and Metabolism
- Ion Channels and Receptors
- Mitochondrial Function and Pathology
- Viral Infections and Vectors
- Neuroscience and Neuropharmacology Research
- Pain Mechanisms and Treatments
- Nutrition, Genetics, and Disease
- interferon and immune responses
- Glaucoma and retinal disorders
Institute of Cytology and Genetics
2015-2024
Siberian Branch of the Russian Academy of Sciences
2011-2024
Novosibirsk State University
2015-2021
Marine Hydrophysical Institute
2018
Russian Academy of Sciences
2009-2012
University of Dayton
2011
Institute of Chemical Biology and Fundamental Medicine
2010
National Institutes of Health
2003-2006
National Center for Biotechnology Information
2004-2005
University of Pennsylvania
2001
The mechanisms and evolutionary dynamics of intron insertion loss in eukaryotic genes remain poorly understood. Reconstruction parsimonious scenarios gene structure evolution paralogous families animals plants revealed numerous gains losses introns. In all analyzed lineages, the number acquired new introns was substantially greater than lost ancestral This trend held even for lineages which vertical involved more gains, suggesting that duplication boosts insertion. However, dating...
Drosophila melanogaster polytene chromosomes display specific banding pattern; the underlying genetic organization of this pattern has remained elusive for many years. In present paper, we analyze 32 cytology-mapped chromosome interbands. We estimated molecular locations these interbands, described their and demonstrate that interbands contain 5' ends housekeeping genes. As a rule, preferential "head-to-head" orientation They are enriched "broad" class promoters characteristic genes...
In the present study, we assessed muscle pain and possible development of muscular hyperalgesia to mechanical stimuli after two subsequent intramuscular infusions serotonin (5-HT) bradykinin (BKN). The intensity was continuously scored on a visual analogue scale (VAS). subjects drew distribution areas map. Pressure thresholds (PPTs) suprapressure (SPPTs) stimulations as 150% pre-infusion PPTs were with pressure algometer at injection site (10 cm below patella), ankle, contralateral leg...
It is well known that non‐coding mRNA sequences are dissimilar in many structural features. For individual mRNAs correlations were found for some of these features and their translational efficiency. However, no systematic statistical analysis was undertaken to relate protein abundance characteristics encoding the given protein. We have demonstrated contextual eukaryotic high‐ low‐abundant proteins differ 5′ untranslated regions (UTR). Statistically, UTRs low‐expression longer, guanine plus...
The 2′–5′-oligoadenylate synthetase (2′–5′-OAS) family members are interferon-induced antiviral proteins. Twenty-three single nucleotide polymorphisms located within the OAS1, OAS2, OAS3, and OASL genes were analyzed in 142 patients with Russian tick-borne encephalitis. Statistically significant differences genotype, allele, haplotype frequencies for 3 OAS2 (rs1293762, rs15895, rs1732778) 2 OAS3 (rs2285932 rs2072136) detected between central nervous system disease both those fever and/or...
Development of anxiety- and depression-like states under chronic social defeat stress in mice has been shown by many experimental studies. In this article, the differentially expressed Slc25* family genes encoding mitochondrial carrier proteins were analyzed brain depressive (defeated) versus aggressive winning everyday confrontations. The collected samples regions sequenced at JSC Genoanalytica ( http://genoanalytica.ru/ , Moscow, Russia). Changes expression 20 male region- experience...
APOE ε4 allele is most common genetic risk factor for Alzheimer's disease (AD) and cognitive decline. However, it remains poorly understood why only some carriers of develop AD how ethnic variabilities in locus contribute to risk. Here, address the role haplotypes, we reassessed diversity major groups Disease Neuroimaging Initiative (ADNI) dataset on patients with AD, subjects mild impairment (MCI), control non-demented individuals. We performed gene haplotype analysis a short block five...
Salivary gland polytene chromosomes demonstrate banding pattern, genetic meaning of which is an enigma for decades. Till now it not known how to mark the band/interband borders on physical map DNA and structures are characterized in molecular terms. It either similar pattern exists regular diploid mitotically dividing nonpolytene cells. Using newly developed approach permitting identify interband material localization data interband-specific proteins from modENCODE other genome-wide...
The studies on CpG islands (CGI) and Alu elements functions, evolution, distribution in the genome started since discovery nineteen eighties (1981, 1986, correspondingly). Their highly skewed wide implies non-random retrotransposition pattern. Besides CGIs gene promoters, clusters were observed homeobox regions macrosatellites, but whole picture of their specifics was not grasped. Attempts to identify any causative features upon (genome wide) distribution, such as DNA context mediated...
After intramuscular (m. tibialis anterior) injection of three different algogenic substances, the pain intensity was continuously scored on a visual analogue scale (VAS) in eight volunteers. The subject drew distribution local and referred areas map. Four times within first hour after injection, pressure pain-thresholds (PPTs) supra pressure-pain thresholds were assessed at point, 2 cm distal from site, arm, contralateral leg. Measurements done before 0.5 ml substance [bradykinin (BKN),...
In course of daily agonistic interactions, mice tend to stratify into those with chronic social defeats and that repeatedly display aggression, which lead the development mixed anxiety/depression-like state pathology aggressive behavior, respectively. Using data whole transcriptome analysis (RNA-seq), changes in expression serotonergic genes involved synthesis, inactivation, reception serotonin, as well Creb1 (transcription factor) gene Bdnf (brain-derived neurotrophic were detected striatum...
Modes of evolution stop codons in protein-coding genes, especially the conservation UAA, have been debated for many years. We reconstructed 40 groups closely related prokaryotic and eukaryotic genomes. The results indicate that UAA are maintained by purifying selection all domains life. In contrast, positive appears to drive switches from UAG other prokaryotes but not eukaryotes. Changes significantly associated with increased substitution frequency immediately downstream stop. These...
Completion of the human genome sequence provides evidence for a gene count with lower bound 30,000–40,000. Significant protein complexity may derive in part from multiple transcript isoforms. Recent EST based studies have revealed that alternate transcription, including alternative splicing, polyadenylation and transcription start sites, occurs within at least 30–40% genes. Transcript form surveys yet to integrate genomic context, expression, frequency, contribution diversity isoform...
Abstract Background In this paper we describe an analysis of the size evolution both protein domains and their indels, as inferred by changing sizes whole or individual unaligned regions "spacers". We studied relatively early evolutionary events focused on which are conserved among various taxonomy groups. Results found that more than one third all have a statistically significant tendency to increase/decrease in judged from overall domain distribution well spacers. Moreover, fraction...
Background Despite extensive research on the genetic determinants of glaucoma, genes identified to date explain only a small proportion cases in general population. Methods Genome-wide linkage and association analyses quantitative traits related glaucoma were performed: intraocular pressure, size morphology optic disc (individual combined by method principal components) thickness retinal nerve fibre layer (RNFL), large pedigree from genetically isolated Dutch Results For disc, study...
Medium spiny neurons (MSNs) comprise the main body (95% in mouse) of dorsal striatum and represent dopaminoceptive GABAergic neurons. The cAMP (cyclic Adenosine MonoPhosphate)-mediated cascade excitation inhibition responses observed MSN intracellular signal transduction is crucial for neuroscience research due to its involvement motor behavioral functions. In particular, all types addictions are related MSNs. Shedding light on mechanics above-mentioned primary importance this domain.