A5053306486- Angiogenesis and VEGF in Cancer
- Axon Guidance and Neuronal Signaling
- Botulinum Toxin and Related Neurological Disorders
- Hippo pathway signaling and YAP/TAZ
- Trigeminal Neuralgia and Treatments
- Facial Nerve Paralysis Treatment and Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Musculoskeletal pain and rehabilitation
- Cerebrospinal fluid and hydrocephalus
- Inflammatory Biomarkers in Disease Prognosis
- Intracranial Aneurysms: Treatment and Complications
- Aortic Disease and Treatment Approaches
- Spine and Intervertebral Disc Pathology
- Medical Imaging and Analysis
- Frailty in Older Adults
- Anesthesia and Pain Management
- Apelin-related biomedical research
- Spinal Cord Injury Research
Charité - Universitätsmedizin Berlin
2018-2025
Humboldt-Universität zu Berlin
2024
Freie Universität Berlin
2022-2024
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2022
OBJECTIVE Operative interposition of material between the trigeminal nerve and offending artery for surgical treatment drug-resistant neuralgia (TGN), following Jannetta method, has been proven to be most successful invasive treatment. Reexplorations patients with recurrence TGN have revealed root irritations scarring due interposed material. To prevent these complications, modifications microvascular decompression (MVD) aim at transposing vessel away from nerve, without attachment...
Abstract Lumbar spinal stenosis (LSS) is a prevalent condition, particularly in elderly patients, characterized by clinical syndrome that includes buttock or lower extremity pain, commonly associated with sensory and motor dysfunction. The surgical management of these patients challenging due to higher rates comorbidities increased risks experiencing complications such as postoperative delirium, leading intensive care prolonged hospital stays. Awake surgery under anaesthesia (SA) has been...
Alterations in vascular morphogenesis are hallmarks of antiangiogenesis-resistant tumor vessels. Vascular is regulated by ephrinB2-EphB4 system which may induce different biological effects depending on the oncological and molecular contexts. It was aim current study to characterize influence EphB4 microcirculation after antiangiogenic treatment using SF126 glioma models.Using an ecotropic transfection system, empty vector (pLXSN) or (EphB4OE) overexpressing Phoenix-ECO cells were...
Elderly patients receiving lumbar fusion surgeries present with a higher risk profile, which necessitates robust predictor of postoperative outcomes. The Red Distribution Width (RDW) is preoperative routinely determined parameter that reflects the degree heterogeneity red blood cells. Thereby, RDW associated frailty in hospital-admitted patients. This study aims to elucidate potential as biomarker predictive prolonged hospital stays following elective mono-segmental surgery elderly In this...
Traumatic spinal cord injury (SCI) is a devastating condition for which effective neuroregenerative and neuroreparative strategies are lacking. The post-traumatic disruption of the blood-spinal barrier (BSCB) as part neurovascular unit (NVU) one major factor in complex pathophysiology SCI, associated with edema, inflammation, cell death penumbra regions adjacent to lesion epicenter. Thus, preservation an intact NVU vascular integrity facilitate regenerative capacity following SCI desirable...
In recent decades, the global incidence of aneurysmal subarachnoid hemorrhage (aSAH) has declined. However, significant regional differences exist. We present first comprehensive analysis time trends in aSAH and case fatality Germany.All patients hospitalized with Germany between 2005 2018 were identified using International Classification Disease, 10th Revision codes I60.0-I60.7.A total 101,105 cases included. The decreased at a mean annual rate 0.5% (p = 0.003) from 8.9 per 100,000...