A5069260534- Developmental Biology and Gene Regulation
- RNA Research and Splicing
- Single-cell and spatial transcriptomics
- Neurogenesis and neuroplasticity mechanisms
- Pancreatic function and diabetes
- Pluripotent Stem Cells Research
- Receptor Mechanisms and Signaling
- Cell Image Analysis Techniques
- Genetics and Neurodevelopmental Disorders
Universität Hamburg
2021-2022
University Medical Center Hamburg-Eppendorf
2021-2022
Université Côte d'Azur
2014-2021
Centre National de la Recherche Scientifique
2015-2021
Inserm
2015-2021
Institut de Biologie Valrose
2015
In the neocortex, functionally distinct areas process specific types of information. Area identity is established by morphogens and transcriptional master regulators, but downstream mechanisms driving area-specific neuronal specification remain unclear. Here, we reveal a role for RNA-binding proteins in defining cytoarchitecture. Mice lacking Pum2 or overexpressing human TDP-43 show apparent 'motorization' layers IV V primary somatosensory cortex (S1), characterized dramatic expansion cells...
The mammalian neocortex, the outer layer of cerebrum and most recently evolved brain region, is characterized by its unique areal laminar organization. Distinct cortical layers areas can be identified protein expression graded transcription factors molecular determinants that define identity different projection neurons. Thus, specific detection visualization crucial for assessing neocortical neurons and, more broadly, understanding early late developmental mechanisms function this complex...