A5006432011- Ultrasound and Hyperthermia Applications
- Ultrasound Imaging and Elastography
- Microwave Imaging and Scattering Analysis
- Ultrasonics and Acoustic Wave Propagation
- Photoacoustic and Ultrasonic Imaging
- Advanced Optical Sensing Technologies
- Wireless Body Area Networks
- Electromagnetic Fields and Biological Effects
- CCD and CMOS Imaging Sensors
- Acoustic Wave Resonator Technologies
- Particle Detector Development and Performance
Chalmers University of Technology
2018-2023
University of Trento
2017
Istituto Nazionale di Fisica Nucleare, Trento Institute for Fundamental Physics And Applications
2017
Abstract Time-reversal (TR) is a known wideband array beam-forming technique that has been suggested as treatment planning alternative in deep microwave hyperthermia for cancer treatment. While the aim classic TR to focus energy at specific point within target, no assumptions are made on secondary lobes might arise healthy tissues. These lobes, together with tissue heterogeneity, may result hot-spots (HSs), which limit efficiency of thermal dose delivery tumor. This paper proposes novel...
Deep microwave hyperthermia applicators are typically designed as narrow-band conformal antenna arrays with equally spaced elements, arranged in one or more rings. This solution, while adequate for most body regions, might be sub-optimal brain treatments. The introduction of ultra-wide-band semi-spherical applicators, elements around the head and not necessarily aligned, has potential to enhance selective thermal dose delivery this challenging anatomical region. However, additional degrees...
Background A necessary precondition for a successful microwave hyperthermia (HT) treatment delivered by phased arrays is the ability of HT applicator to selectively raise temperature entire tumor volume. SAR-based plan (HTP) optimization methods exploit correlation between specific absorption rate (SAR) and increase in order determine set steering parameters optimal focusing, while allowing lower model complexity. Several cost functions have been suggested past this problem. However, their...
Combining radiotherapy (RT) with hyperthermia (HT) has been proven effective in the treatment of a wide range tumours, but combination externally delivered, focused heat and stereotactic radiosurgery never investigated. We explore potential such enhancement via radiobiological modelling, specifically linear-quadratic (LQ) model adapted to thermoradiotherapy through modulating radiosensitivity temperature-dependent parameters. extend this well-established by incorporating oxygenation effects....
Microwave hyperthermia treatment planning (HTP) is a multi-objective task for which several cost functions have been suggested over the years. The power distribution inside patient, achieved by amplitude and phase steering of applicator array, must fulfill diverse requirements. On one hand, high homogeneous target deposition required temperature elevation. other, healthy tissues should not be subjected to excessive heating hot-spots outside suppressed. To these ends, two major SAR- based...
Thermal dose delivery in microwave hyperthermia for cancer treatment is expected to benefit from the introduction of ultra-wideband (UWB)-phased array applicators. A full exploitation combination different frequencies improve deposition pattern is, however, a nontrivial problem. It unclear whether cost functions used planning (HTP) optimization single-frequency setting can be meaningfully extended UWB case.We discuss ability eigenvalue (EV) and novel implementation iterative-EV (i-EV)...
In this paper, we present a two-layered silicon sensor working in Geiger-mode avalanche regime and designed for charged particle detection. Each position-sensitive element is comprised of two vertically aligned pixels, exploiting the coincidence between simultaneous events to discriminate triggers dark counts. This approach potentially offers several advantages. First, low material budget can be achieved thanks thinning detector down few tens microns (e.g. 50 μm) as starts shallow region...
In deep microwave hyperthermia (MW-HT), antenna arrays are used to generate an interference pattern which focuses energy in the tumor location.These subject a number of disturbances must be compensated for through calibration.This paper proposes and analyzes pair self-calibration algorithms, i.e. calibration procedures rely only on S-matrix measurements N-port array applicator device, avoiding need external references making real-time in-treatment possible.Two algorithms analyzed by means...
Phased array applicators for deep microwave hyperthermia struggle to reach satisfying target-to-remaining power absorption ratios in the brain area. In our opinion, this is partly because their design meant an overall body region rather than a particular tumor. A paradigm shift antenna arrangement thus necessary: from regional applicator arrays target-specific ones. Exploring all possible configurations and simulate them, however, computationally unfeasible. This conference contribution...