A5060466797- Receptor Mechanisms and Signaling
- Asthma and respiratory diseases
- Neuropeptides and Animal Physiology
- SARS-CoV-2 and COVID-19 Research
- Pharmaceutical studies and practices
- COVID-19 Clinical Research Studies
- Pharmacological Effects and Assays
- Protein Kinase Regulation and GTPase Signaling
- Pharmaceutical Economics and Policy
- Intramuscular injections and effects
- Cardiomyopathy and Myosin Studies
- Pediatric Pain Management Techniques
- Pain Mechanisms and Treatments
- Blood disorders and treatments
- Cardiac electrophysiology and arrhythmias
- Neonatal Respiratory Health Research
- Cell Adhesion Molecules Research
- Hormonal Regulation and Hypertension
- Heparin-Induced Thrombocytopenia and Thrombosis
- Peripheral Neuropathies and Disorders
- Urinary Bladder and Prostate Research
- Respiratory and Cough-Related Research
- Long-Term Effects of COVID-19
- Cardiovascular Effects of Exercise
- Cardiovascular Function and Risk Factors
PhysioGenix (United States)
2015-2025
VIR Biotechnology (United States)
2021-2025
Universidad de Antioquia
2000-2024
University of Houston
2007-2023
Hospital General Universitario Gregorio Marañón
2017-2019
Centro de Investigación en Red en Enfermedades Cardiovasculares
2017
Michigan State University
2016
University of Michigan–Ann Arbor
2012-2016
Hospital Universitario Puerta de Hierro Majadahonda
2013
Michigan United
2012
Older patients and those with comorbidities who are infected SARS-CoV-2 may be at increased risk of hospitalization death. Sotrovimab is a neutralizing antibody for the treatment high-risk to prevent COVID-19 progression.To evaluate efficacy adverse events sotrovimab in preventing progression mild moderate severe disease.Randomized clinical trial including 1057 nonhospitalized symptomatic, least 1 factor conducted 57 sites Brazil, Canada, Peru, Spain, US from August 27, 2020, through March...
Single-dose administration of beta-adrenoceptor agonists produces bronchodilation and inhibits airway hyperresponsiveness (AHR), is the standard treatment for acute relief asthma. However, chronic repetitive may increase AHR, inflammation, risk death. Based upon paradigm shift that occurred with use beta-blockers in congestive heart failure, we previously determined decreased AHR a murine model To elucidate mechanisms beneficial effects beta-blockers, examined several ligands allergic...
Chronic regular use of β 2 -adrenoceptor (β -AR) agonists in asthma is associated with a loss disease control and increased risk death. Conversely, we have found that administration -AR inverse results attenuation the phenotype an allergen-driven murine model. Besides antagonizing agonist-induced signaling reducing by empty receptors, β-AR can also activate novel pathways. To determine mechanism agonists, compared -AR-null wild-type mice. Antigen challenge mice produced similar to what was...
urpose: The aim of this study was to compare the bioavailability two formulations metformin 850 mg tablets: Glucophage® from Merck Santè laboratories (reference product) and Metformin Winthrop Pharmaceuticals de Colombia SA (test in healthy Colombian volunteers. Methods: A random, double blind, two-period, two-week wash out period, crossover performed 24 male female volunteers for a single 850-mg dose tablets administrated with 240 ml water after 12 hours fasting. Once drug administrated,...
ClinicalTrials.gov identifier, NCT05280717.
Abstract New analgesics are needed for painful wounds. Multiple reports suggest that topical sevoflurane may have analgesic effects. This placebo‐controlled randomised trial evaluated the efficacy and safety of VPX638 (topical sevoflurane). Seventy‐eight participants with wounds, were enrolled at eight Australian centres randomly allocated to receive 2 × 5 mL ( N = 39) or placebo 40) during one wound dressing change. Numerical pain rating scores use opioids recorded 24 h. The primary...
The mostly widely used bronchodilators in asthma therapy are β2-adrenoreceptor (β2AR) agonists, but their chronic use causes paradoxical adverse effects. We have previously determined that β2AR activation is required for expression of the phenotype mice, cell types involved unknown. now demonstrate signaling airway epithelium sufficient to mediate key features asthmatic responses IL-13 murine models. Our data show inhibition with an aerosolized antagonist attenuates hyperresponsiveness...
Convenient administration of coronavirus disease 2019 (COVID-19) treatment in community settings is desirable. Sotrovimab a pan-sarbecovirus dual-action monoclonal antibody formulated for intravenous (IV) or intramuscular (IM) early mild/moderate COVID-19.
Regulator of G protein signaling (RGS) proteins have emerged as novel drug targets since their discovery almost two decades ago. RGS2 has received particular interest in cardiovascular research due to its role regulating G<sub>q</sub> the heart and vascular smooth muscle. RGS2<sup>−/−</sup> mice are hypertensive, prone failure, display accelerated kidney fibrosis. is rapidly degraded through proteasome, human mutations leading degradation correlate with hypertension. Hence, stabilizing...
Regulator of G protein signaling 2 (RGS2), a G<sub>q</sub>-specific GTPase-activating protein, is strongly implicated in cardiovascular function. RGS2(−/−) mice are hypertensive and prone to heart failure, several rare human mutations that accelerate RGS2 degradation have been identified among patients with hypertension. Therefore, pharmacological up-regulation levels might be beneficial. We used β-galactosidase complementation method screen thousand compounds known functions for those...
Background and Purpose Our previous studies have shown the β 2 ‐adrenoceptor its endogenous ligand, adrenaline, are required for development of asthma phenotype in murine models. Chronic administration some, but not other, β‐blockers attenuated led us to hypothesize that biased signalling was basis their differential effects, experimentally clinically. Experimental Approach We used mice with no detectable systemic adrenaline (PNMT ‐/‐ ) wild‐type (WT) study effects four β‐blockers,...
Mice lacking the endogenous β2-adrenoceptor (β2AR) agonist epinephrine (phenylethanolamine N-methyltransferase [PNMT]-knockout mice) are resistant to developing an "asthma-like" phenotype in ovalbumin sensitization and challenge (Ova S/C) model, chronic administration of β2AR agonists PNMT-KO mice restores phenotype. Based on these other studies showing differential effects various ligands asthma phenotype, we have speculated that permissive effect exogenous allergic lung inflammation can be...
Abstract Importance Older patients and those with underlying comorbidities infected SARS-CoV-2 may be at increased risk of hospitalization death from COVID-19. Sotrovimab is a neutralizing antibody designed for treatment high-risk to prevent COVID-19 progression. Objective To evaluate the efficacy safety sotrovimab in preventing progression mild moderate severe disease. Design Randomized, double-blind, multicenter, placebo-controlled, phase 3 study. Setting 57 centers 5 countries....
The nomenclature of the Adrenoceptors has been agreed by NC-IUPHAR Subcommittee on [58], see also [180]. Adrenoceptors, α1α1-Adrenoceptors are activated endogenous agonists (-)-adrenaline and (-)-noradrenaline. phenylephrine, methoxamine cirazoline prazosin antagonists considered selective for α1- relative to α2-adrenoceptors. [3H]prazosin [125I]HEAT (BE2254) relatively radioligands. S(+)-niguldipine high affinity L-type Ca2+ channels. Fluorescent derivatives (Bodipy PLprazosin- QAPB) used...
The nomenclature of the Adrenoceptors has been agreed by NC-IUPHAR Subcommittee on [64, 194]. Adrenoceptors, α1 three α1-adrenoceptor subtypes α1A, α1B and α1D are activated endogenous agonists (-)-adrenaline (-)-noradrenaline. -(-)phenylephrine, methoxamine cirazoline prazosin doxazosin antagonists considered selective for α1- relative to α2-adrenoceptors. [3H]prazosin [125I]HEAT (BE2254) relatively radioligands. S(+)-niguldipine also high affinity L-type Ca2+ channels. Fluorescent...
Abstract Background Five hundred milligrams of intravenous (IV) sotrovimab has been shown to be well tolerated and efficacious against pre-Omicron strains in treating patients with mild moderate coronavirus disease 2019 (COVID-19) at high risk for progression. Methods This was an open-label, single-arm substudy phase 3 COMET-TAIL (NCT04913675) assessing the safety tolerability a 2000 mg IV dose sotrovimab. Symptomatic (aged ≥18 years) COVID-19 progression were enrolled from June 30 through...
Regulator of G protein signaling (RGS) proteins suppress coupled receptor by catalyzing the hydrolysis Gα-bound guanine nucleotide triphosphate. Transgenic mice in which RGS-mediated regulation Gαi2 is lost (RGS insensitive G184S) exhibit beneficial (protection against ischemic injury) and detrimental (enhanced fibrosis) cardiac phenotypes. This mouse model has revealed physiological significance RGS/Gαi2 interactions. Previous studies G184S mutation used that express this mutant throughout...
The nomenclature of the Adrenoceptors has been agreed by NC-IUPHAR Subcommittee on [60, 186]. Adrenoceptors, α1 three α1-adrenoceptor subtypes α1A, α1B and α1D are activated endogenous agonists (-)-adrenaline (-)-noradrenaline. -(-)phenylephrine, methoxamine cirazoline prazosin doxazosin antagonists considered selective for α1- relative to α2-adrenoceptors. [3H]prazosin [125I]HEAT (BE2254) relatively radioligands. S(+)-niguldipine also high affinity L-type Ca2+ channels. Fluorescent...