A5059497653- Nanoplatforms for cancer theranostics
- Electrochemical sensors and biosensors
- Photodynamic Therapy Research Studies
- Photoreceptor and optogenetics research
- Synthesis and Properties of Aromatic Compounds
- Advanced Chemical Sensor Technologies
- Supramolecular Self-Assembly in Materials
- Supramolecular Chemistry and Complexes
- Photochromic and Fluorescence Chemistry
- Oxidative Organic Chemistry Reactions
- Analytical Chemistry and Sensors
- Radical Photochemical Reactions
- Luminescence and Fluorescent Materials
- Advanced biosensing and bioanalysis techniques
- Catalytic C–H Functionalization Methods
- Photoacoustic and Ultrasonic Imaging
- Porphyrin and Phthalocyanine Chemistry
Universidad Autónoma de Madrid
2021-2024
We present the synthesis, photophysical properties, and biological application of nontoxic 3-azo-conjugated BODIPY dyes as masked fluorescent biosensors hypoxia-like conditions. The synthetic methodology is based on an operationally simple N═N bond-forming protocol, followed by a Suzuki coupling, that allows for direct access to underexplored 3-azo-substituted BODIPY. These can turn their emission properties under both chemical reductive conditions, including bacterial human azoreductases,...
Chiral metallo-supramolecular fibres can be easily obtained by mixing a chloroform solution of phenylacetylene monomer (PA) that bears chiral sulfoxide group as pendant, with different equivalents methanolic AgClO
A straightforward methodology for the regioselective synthesis of pyrazoles has been developed by a domino sequence based on photoclick cycloaddition followed photocatalyzed oxidative deformylation reaction. Distinguishing features this protocol include an unprecedented photoredox-catalyzed Norrish type fragmentation under green-light irradiation and use α,β-unsaturated aldehydes as synthetic equivalents alkynes, where aldehyde is acting novel photoremovable directing group.
Abstract Chiral metallo‐supramolecular fibres can be easily obtained by mixing a chloroform solution of phenylacetylene monomer (PA) that bears chiral sulfoxide group as pendant, with different equivalents methanolic AgClO 4 . Thus, while the PA is found molecularly dissolved in chloroform, addition Ag + ions induce its aggregation through formation an axially aggregate high thermal stable properties. In this case, ability metal ion to coordinate triple bond, combined argentophilicity and...
Herein we report the synthesis and biological properties of sugar-conjugated oligophenylene ethynylene (OPE) dyes, used as novel photosensitizers (PSs) for photodynamic treatment (PDT) under blue light. The OPE-bearing glycosides at both ends are successfully prepared by a Pd-catalyzed Sonogashira cross-coupling reaction. live-cell imaging studies have shown that these OPE (including glucose, mannose maltose derivatives) efficiently penetrate cytoplasm cultured HeLa cancer cells. No dark...
Functionalized upconverting nanoparticles (UCNPs) are promising theragnostic nanomaterials for simultaneous therapeutic and diagnostic purposes. We present two types of non-toxic eosin Y (EY) nanoconjugates derived from UCNPs as novel nanophotosensitizers (nano-PS) deep-tissue bioimaging agents employing light at 800 nm. This excitation wavelength ensures minimum cell damage, since the absorption water is negligible, increases tissue penetration, enhancing specificity photodynamic treatment...