A5034291730- Epilepsy research and treatment
- Bacterial Infections and Vaccines
- Parasitic infections in humans and animals
- Neonatal and fetal brain pathology
- Pharmacological Effects and Toxicity Studies
- Infectious Encephalopathies and Encephalitis
- Metabolism and Genetic Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- Family and Disability Support Research
- Cerebrospinal fluid and hydrocephalus
- Congenital Anomalies and Fetal Surgery
- Cerebral Palsy and Movement Disorders
- Infectious Diseases and Tuberculosis
- Peripheral Neuropathies and Disorders
- Child Nutrition and Feeding Issues
- Infant Development and Preterm Care
- Autoimmune Neurological Disorders and Treatments
- Parasite Biology and Host Interactions
- Neurological Complications and Syndromes
- Parasites and Host Interactions
- Fetal and Pediatric Neurological Disorders
- Neonatal Respiratory Health Research
- Attention Deficit Hyperactivity Disorder
Post Graduate Institute of Medical Education and Research
2015-2024
Medanta The Medicity
2017-2024
Amrita Institute of Medical Sciences and Research Centre
2023-2024
Medanta The Medicity
2019-2022
National Institute of Mental Health and Neurosciences
2021
Jawaharlal Institute of Post Graduate Medical Education and Research
2015-2020
Government Medical College and Hospital
2020
Laboratory of Molecular Genetics
2016
Laboratoire de Génétique Médicale
2016
Hôpitaux Universitaires de Strasbourg
2016
Environmental manganese (Mn) toxicity causes an extrapyramidal, parkinsonian-type movement disorder with characteristic magnetic resonance images of Mn accumulation in the basal ganglia. We have recently reported a suspected autosomal recessively inherited syndrome hepatic cirrhosis, dystonia, polycythemia, and hypermanganesemia cases without environmental exposure. Whole-genome mapping two consanguineous families identified SLC30A10 as affected gene this type hypermanganesemia. This was...
Some open-label studies suggest that risperidone can be useful in the treatment of certain target symptoms children with autism. We aimed to study whether use comparison placebo improved functioning autism regard behavior (aggressiveness, hyperactivity, irritability), social and emotional responsiveness, communication skills. conducted a randomized, double-blind, placebo-controlled trial 40 consecutive autism, whose ages ranged from 2 9 years, who were receiving either or given orally at...
Neurocysticercosis is a major cause of neurologic illness worldwide. Its manifestations are variable, and somewhat different when it occurs in children. Controversy exists regarding anticysticercal therapy. The clinical, laboratory, radiographic features 500 consecutive children with neurocysticercosis were studied; the then followed prospectively their response to albendazole therapy was analyzed. Diagnosis based primarily on neuroimaging. Computed tomographic (CT) scans, serology, chest...
Single small enhancing computerized tomographic (CT) lesions (SSECTLs) are common in children with focal seizures. These considered to represent solitary cysticercus granulomas. Controversy exists regarding their treatment.To evaluate the efficacy of albendazole cases seizures SSECTLs.Randomized, placebo-controlled, double blind trial.Pediatric service Nehru Hospital, PGIMER, an urban tertiary care teaching hospital.63 between 2 and 12 years age for <3 months SSECTLs.All were randomly...
To study the spectrum of epilepsy in children with cerebral palsy, 105 consecutive palsy and active epilepsy, between 1 14 years age, were studied prospectively. A detailed history examination, electroencephalography (EEG), computed tomography (CT) done all cases. The social quotient was assessed using Vineland Social Maturity Scale. retrospective cohort 452 cases to find prevalence palsy. control group 60 age-matched but no also for comparison quotient. Of children, 65 male, 40 (38%) had a...
The objective of this study was to compare the efficacy continuous midazolam and diazepam infusion for control refractory status epilepticus. An open-label, randomized undertaken at Pediatric Emergency Intensive Care Service a multidisciplinary teaching referral hospital. Subjects included 40 children, 2 12 years age, with epilepticus (motor seizures uncontrolled after two doses diazepam, 0.3 mg/kg per dose, phenytoin infusion, 20 mg/kg). Either (n = 21) or 19) in incremental administered....
An open-label, randomized controlled study was conducted at a tertiary care teaching hospital to compare efficacy and safety of intravenous sodium valproate versus diazepam infusion for control refractory status epilepticus. Forty children with epilepticus were receive either or infusion. Refractory in 80% the 85% patients. The median time less group (5 minutes) than (17 minutes; P < .001). None patients required ventilation developed hypotension, whereas 60% 50% hypotension after starting...
Clinical spectrum of cerebral palsy (CP) is different in developing and developed countries. We evaluated the clinical profile, etiological factors co-morbidities children with CP North India, compared our previous study.1212 registered last 10 years rehabilitation center were study 1000 from same center.Spastic quadriplegia commonest type (51.5%) although lesser than decade (61%). Birth asphyxia remains main (51.98%) factor as earlier (45.3%). due to CNS infections decreased 63.5% 57.4%,...
One thousand children with cerebral palsy (CP) were reviewed to study their clinical profile, etiological factors and associated problems. Spastic quadriplegia constituted the predominant group (61 per cent), followed by spastic diplegia (22 cent). Dyskinetic CP was present in 7.8 cent of cases. Acquired CP, particularly secondary nervous system infections, a significant proportion The spectrum is different developing countries compared developed countries. Associated problems majority (75...
Several large, randomized controlled trials have demonstrated the efficacy of topiramate in migraine prophylaxis adults. However, there are limited data about use children. We conducted this single-center, double-blind, placebo-controlled trial to evaluate and safety A total 44 children with were using random number tables receive (n = 22) or placebo 22). The duration treatment was 4 months, including a baseline period 1 month during which titrated weekly 25-mg increments 100 mg/d 2 divided...
Neurocysticercosis (NCC) is the most common cause of acquired epilepsy in developing countries. It can present variably depending on location and stage cysts nervous system, host immune response. The presentation parenchymal NCC with seizures that are usually focal brief; status epilepticus occurs some cases. About a third cases have headache vomiting. Diagnosis made by either CT or MRI. Single, small, contrast enhancing lesions common; visualization scolex diagnostic. Some multiple...
Objective: In children with acute CNS infection, management of raised intracranial pressure improves mortality and neuromorbidity. We compared cerebral perfusion pressure–targeted approach the conventional to treat in these children. Design: Prospective open-label randomized controlled trial. Setting: PICU a tertiary care academic institute. Patients: Hundred ten (1–12 yr) infections having modified Glasgow Coma Scale score less than or equal 8 were enrolled. Interventions: Patients receive...
Congenital insensitivity to pain (CIP) and hereditary sensory autonomic neuropathies (HSAN) are clinically genetically heterogeneous disorders exclusively or predominantly affecting the neurons. Due rarity of diseases findings based mainly on single case reports small series, knowledge about these is limited. Here, we describe molecular workup a large international cohort CIP/HSAN patients including from normally under-represented countries. We identify 80 previously unreported pathogenic...
Single small enhancing computed tomographic (CT) lesions representing cysticercus granuloma are a common cause of focal seizures in children. Controversy exists regarding the efficacy various modalities treatment. We conducted randomized prospective trial to evaluate corticosteroids, albendazole, and corticosteroids with albendazole children single CT lesions. The study population consisted 133 recent onset (< 3 months) who presented Neurocysticercosis Clinic Pediatric Neurology Services...
Psychosocial problems faced by parents and other family members were studied in 50 families with a physically disabled child (PD group), mentally retarded (MR group) healthy (control group). A semi-structured questionnaire assisted interview standardized scales used to measure social burden, marital adjustment maternal neuroticism. Families children perceived greater financial stress, frequent disruption of routine leisure, poor interaction, ill effects on their physical mental health as...
The utility of the WHO Ten Questions Screen (TQS) was studied in a rural community North India. study done three villages, two phases. In phase 1, TQS administered to parents children aged between 2 and 9 years, during house-to-house survey. 2, all screened positive random sample 110 negative were clinically evaluated detail. total population villages 5830 with 1763 years. Seventy-six on TQS, these, 38 found have significant disability, 18 had protein energy malnutrition 19 normal clinical...