A5081545346- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Reproductive System and Pregnancy
- Systemic Lupus Erythematosus Research
- Sphingolipid Metabolism and Signaling
- Liver Disease Diagnosis and Treatment
- Gut microbiota and health
- Bioactive Compounds and Antitumor Agents
- Immune Cell Function and Interaction
- Pregnancy and preeclampsia studies
- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Ginseng Biological Effects and Applications
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Barrier Structure and Function Studies
- Diabetic Foot Ulcer Assessment and Management
- Metabolomics and Mass Spectrometry Studies
- Mycobacterium research and diagnosis
- Diet, Metabolism, and Disease
- Zebrafish Biomedical Research Applications
National Clinical Research Center for Digestive Diseases
2024
First Affiliated Hospital Zhejiang University
2024
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2024
Zhejiang University
2024
Nanjing University
2020-2023
Nanjing Drum Tower Hospital
2023
Zhongshan Hospital
2022
Neuropsychiatric systemic lupus erythematosus (NPSLE) is a severe complication, which involves pathological damage to the brain and cognitive function. However, its exact mechanism of action still remains unclear. In this study, we explored role microglia in dysfunction NPSLE mice. We also analyzed compared metabolites hippocampal tissues model control mice.MRL/MpJ-Faslpr (MRL/lpr) female mice were used as mouse model. Metabolomics was assess glycolysis levels. Glucose, lactic acid, IL-6,...
Abstract Background Neuropsychiatric systemic lupus erythematosus (NPSLE), with various morbidities and multiple manifestations in the central nervous system, remains a limited standard for diagnosis. Our study was to discover novel biomarkers improving diagnostic efficiency NPSLE. Methods We performed quantitative planar protein antibody microarray screen 1000 proteins cerebrospinal fluid from controls, (SLE, non-NPSLE) patients, NPSLE patients. Differentially expressed (DEPs) as candidate...
Abstract The exact relationship between inflammatory bowel disease (IBD) and gut microbiota (GM) is still unclear. This study aimed to explore the cause-and-effect IBD GM by Mendelian randomization (MR) analysis. data used in this were obtained from Genome-Wide Association Studies (GWAS). Dutch Microbiome Project included 207 taxa 205 microbiota-associated pathways. Multivariate (MVMR) analysis was performed investigate IBD. results demonstrated that susceptibility developing negatively...
Abstract Background Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that results from widespread immune complex deposition and secondary tissue injury. Hydroxychloroquine (HCQ) has been used clinically to treat SLE, while its exact mechanism still remained elusive. Some studies have shown myeloid-derived suppressor cells (MDSCs) play vital role in the regulation of SLE. In this study, we aimed explore effects HCQ on apoptosis MDSCs mice possible molecular regulatory...
Shikonin is an anti-inflammatory natural herbal drug extracted from Lithospermum erythrorhizon and its therapeutic effect on neuropsychiatric systemic lupus erythematosus (NPSLE) yet unknown. In our study, significantly reversed the cognitive impairment alleviated brain tissue damage in NPSLE mice. The permeability of blood-brain barrier was also verified to be repaired Shikonin-treated particular, we found that neuroinflammation through inhibiting β-catenin signaling pathway, thereby...
<sec> <title>BACKGROUND</title> Metabolically associated fatty liver disease (MAFLD) insidiously affects people's health, and many models have been proposed for the evaluation of fibrosis. However, there is still a lack noninvasive sensitive to screen MAFLD in high-risk populations. </sec> <title>OBJECTIVE</title> The purpose this study was explore new method early screening public establish home-based tool regular self-assessment monitoring MAFLD. <title>METHODS</title> In cross-sectional...
Metabolically associated fatty liver disease (MAFLD) insidiously affects people's health, and many models have been proposed for the evaluation of fibrosis. However, there is still a lack noninvasive sensitive to screen MAFLD in high-risk populations.
Abstract Background Neuropsychiatric systemic lupus erythematosus (NPSLE) is the severest complication of SLE, which often involves pathological damage to brain and cognitive function. Glucose metabolic changes are observed in SLE patients with impairments by medical imaging. Pyruvate kinase isoform M2 (PKM2) a vital catalyzer glucose catabolic pathways neurological diseases. However, PKM2 regarding progress NPSLE remains poorly studied. Thus, this study aimed analyze compare central carbon...
Abstract Background Out-of-bed mobilization is a significant component within the rehabilitation of people early after stroke. A top priority in acute stroke research determining optimal dose out-of-bed exercises, such as frequency and timing. However, there little evidence appropriate for patients. Aims The aim study described this protocol to investigate effect higher-frequency on functional recovery Methods This prospective randomized three-arm trial with assessor blinded intervention. 45...