A5036952183- Mechanical Circulatory Support Devices
- Transplantation: Methods and Outcomes
- Cardiac Structural Anomalies and Repair
- Cardiac Arrhythmias and Treatments
- Cardiac Valve Diseases and Treatments
- Nitric Oxide and Endothelin Effects
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Effects of Exercise
- Pluripotent Stem Cells Research
- COVID-19 and healthcare impacts
- Heart Failure Treatment and Management
- Cardiac Arrest and Resuscitation
- Ion channel regulation and function
- Telemedicine and Telehealth Implementation
- Tissue Engineering and Regenerative Medicine
- Congenital heart defects research
- Viral Infections and Immunology Research
- Neuroscience of respiration and sleep
- Fuel Cells and Related Materials
- Cardiac electrophysiology and arrhythmias
- Eicosanoids and Hypertension Pharmacology
- Cardiovascular Conditions and Treatments
- Renal Transplantation Outcomes and Treatments
- Cardiovascular Function and Risk Factors
- Infective Endocarditis Diagnosis and Management
University of California, Los Angeles
2014-2024
Ronald Reagan UCLA Medical Center
2021-2024
UCLA Health
2018
KTH Royal Institute of Technology
2014
Memorial Hospital
2014
Science for Life Laboratory
2014
Zhongshan Hospital
2014
Miller Children's & Women's Hospital
2014
Long Beach Medical Center
2014
Marina Del Rey Hospital
2013
Background Acute myocardial infarction complicated by cardiogenic shock (AMI‐CS) is associated with significant morbidity and mortality. Mechanical circulatory support (MCS) devices increase systemic blood pressure end organ perfusion while reducing cardiac filling pressures. Methods Results The National Cardiogenic Shock Initiative (NCT03677180) a single‐arm, multicenter study. purpose of this study was to assess the feasibility effectiveness utilizing early MCS Impella in patients...
Renal arteries (RAs) dilate in response to hypoxia, whereas the pulmonary (PAs) constrict. In PA, O 2 tension is detected by an unidentified redox sensor, which controls K + channel function and thus smooth muscle cell (SMC) membrane potential cytosolic calcium. Mitochondria are important regulators of cellular status candidate vascular sensors. Mitochondria-derived activated oxygen species (AOS), like H , can diffuse cytoplasm cause vasodilatation activating sarcolemmal channels. We...
Hypoxic pulmonary vasoconstriction (HPV) is initiated by inhibition of O 2 -sensitive, voltage-gated (Kv) channels in arterial smooth muscle cells (PASMCs). Kv depolarizes membrane potential (E M ), thereby activating Ca 2+ influx via channels. HPV weak extrapulmonary, conduit arteries (PA) and strong precapillary resistance arteries. We hypothesized that regional heterogeneity reflects a longitudinal gradient the function/expression PASMC -sensitive In adult male Sprague Dawley rats,...
Functional closure of the human ductus arteriosus (DA) is initiated within minutes birth by O2 constriction. It occurs an incompletely understood mechanism that intrinsic to DA smooth muscle cell (DASMC). We hypothesized alters function sensor (the mitochondrial electron transport chain, ETC) thereby increasing production a diffusible redox-mediator (H2O2), thus triggering effector (inhibition DASMC voltage-gated K+ channels, Kv). constriction was evaluated in 26 DAs (12 female, aged 9+/-2...
SPECIFIC AIMSHypoxic pulmonary vasoconstriction (HPV), a vasomotor mechanism that matches regional perfusion to ventilation, is initiated by the inhibition of 4-aminopyridine (4-AP) -sensitive, voltage-gated, potassium channels (Kv), resulting in membrane depolarization, opening voltage-gated calcium channels, and vasoconstriction. We used gene targeting create mice lacking candidate O2-sensitive channel, Kv1.5, evaluate hypothesis loss Kv1.5 would impair HPV.PRINCIPAL FINDINGS1. Gene...
Hemodynamic-guided management with a pulmonary artery pressure sensor (CardioMEMS) is effective in reducing heart failure hospitalization patients chronic failure. This study aims to determine the feasibility and clinical utility of CardioMEMS system manage supported left ventricular assist devices (LVADs). In this multicenter prospective study, we followed HeartMate II (n=52) or 3 (n=49) LVADs PA Sensors measured pressure, 6-minute walk distance, quality life (EQ-5D-5 L scores), rates...
Intrapulmonary veins (PVs) contribute to pulmonary vascular resistance, but the mechanisms controlling PV tone are poorly understood. Although smooth muscle cell (SMC) K + channels regulate in most beds, their role is unknown. We show that voltage-gated (K V ) and inward rectifier ir control resting rat. PVs have a coaxial structure, with layers of cardiomyocytes (CMs) arrayed externally around subendothelial layer typical SMCs, thus forming spinchterlike structures. PVCMs both an current,...
BackgroundThe impact of telehealth on cardiovascular care during the COVID-19 pandemic patient satisfaction and factors associated with are not well characterized.MethodsWe conducted a nonrandomized, prospective cross-sectional survey study for outpatient visits over 169-day period utilizing validated usability questionnaire. For each variable, patients were divided into 2 groups—1 scores above median, labeled "greater satisfaction," other below "less satisfaction."ResultsA total 13,913...
ObjectiveAlthough extracorporeal life support (ECLS) has been increasingly adopted as rescue therapy for cardiac and pulmonary failure, it remains limited to specialized centers. The present study reports our institutional experience with mobile ECLS across broad indications, including postcardiotomy syndrome, cardiogenic shock, COVID-19 acute respiratory failure.MethodsWe performed a retrospective review of all patients transported institution through program from January 1, 2018, 15,...
Abstract Background The new United Network for Organ Sharing (UNOS) heart allocation policy prioritizes temporary percutaneous over durable left ventricular assist devices (LVAD) as bridge to transplant. We sought examine 1‐year outcomes of transplant recipients bridged with Impella versus LVADs. Methods All primary adult orthotopic registered in UNOS between January 2016 and June 2021 were analyzed. Recipients identified being isolated or LVAD at the time Baseline characteristics compared...
A 22-year-old woman with primary pulmonary hypertension presented displacement of stents that had been implanted in the left main coronary artery and migrated into aorta. She referred to our center for evaluation lung transplantation.
Abstract Objectives To evaluate characteristics and outcomes of patients presenting with acute myocardial infarction cardiogenic shock (AMICS) during the coronavirus disease 2019 (COVID‐19) pandemic. Background The COVID‐19 pandemic has created challenges in delivering cardiovascular care. Quality measures AMICS United States have not been well described. Methods We identified 406 from National Cardiogenic Shock Initiative (NCSI) divided them into those before ( N = 346, 5/9/2016−2/29/2020)...
Heart transplant selection committee meetings have transitioned from in-person to remote video during the COVID-19 pandemic, but how this impacts members and patient outcomes is unknown.The aim of study determine perceived impact on usability care measure transition period virtual meetings.A 35-item anonymous survey was developed distributed electronically heart committee. We reviewed medical records compare patients presented at (January-March 2020) those (March-June 2020).Among 83 queried,...