A5060735528- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Advanced Memory and Neural Computing
- Neuroscience and Neural Engineering
- Photoreceptor and optogenetics research
- Neural Networks and Applications
- Neurogenesis and neuroplasticity mechanisms
- Vestibular and auditory disorders
- Microtubule and mitosis dynamics
- Axon Guidance and Neuronal Signaling
- stochastic dynamics and bifurcation
- Lipid Membrane Structure and Behavior
- Ion channel regulation and function
- Hearing, Cochlea, Tinnitus, Genetics
- Receptor Mechanisms and Signaling
- Primate Behavior and Ecology
- Electrochemical Analysis and Applications
- Ethics and Social Impacts of AI
- Fuzzy Logic and Control Systems
- Species Distribution and Climate Change
- Fault Detection and Control Systems
- Gene Regulatory Network Analysis
- Advanced Control Systems Optimization
- EEG and Brain-Computer Interfaces
University of Stirling
2015-2025
Charité - Universitätsmedizin Berlin
2016
Bernstein Center for Computational Neuroscience Berlin
2016
National Institute of Allergy and Infectious Diseases
2006
National Institutes of Health
2006
University of Edinburgh
1994-2001
Universities UK
1999
The University of Queensland
1988-1994
Australian National University
1993-1994
Abstract It has been proposed that the hippocampal theta rhythm (4–7 Hz) can contribute to memory formation by separating encoding (storage) and retrieval of memories into different functional half‐cycles (Hasselmo et al. ( 2002 ) Neural Comput 14:793–817). We investigate, via computer simulations, biophysical mechanisms which storage recall spatio‐temporal input patterns are achieved CA1 microcircuitry. A model microcircuit is presented uses representations major cell types, including...
Short-term facilitation and depression have a profound influence on transmission at many glutamatergic synapses, particularly during trains of stimuli. A major component these processes is postsynaptic receptor desensitization. Both presynaptic mechanisms can contribute to synaptic efficacy, but it often difficult define their respective contributions. Blockers desensitization such as cyclothiazide (CTZ) be used, drugs nonspecific effects transmitter release, complicating attempts...
1. During presynaptic inhibition, an increased conductance in the membrane of bouton is presumed to reduce action potential, thereby reducing transmitter release. The object simulation has been determine magnitude a chloride required release, for various diameters synaptic boutons, connected axons with range 0.1-1.0 microns. 2. A propagating potential was simulated either side hemispherical bouton. could be myelinated or unmyelinated, while passive, node nerve, have same active properties as...
Abstract Primates are facing an impending extinction crisis, driven by extensive habitat loss, land use change and hunting. Climate is additional threat, which alone or in combination with other drivers, may severely impact those taxa unable to track suitable environmental conditions. Here, we investigate the extent of climate use/cover (LUC) change‐related risks for primates. We employed analytical approach objectively select a subset scenarios, then calculated changes climatic LUC...
It is well established that synaptic transmission declines at temperatures below physiological, but many in vitro studies are conducted lower temperatures. Recent evidence suggests temperature‐dependent changes presynaptic mechanisms remain overall equilibrium and have little effect on transmitter release low frequencies. Our objective was to examine the postsynaptic effects of temperature. Whole‐cell patch‐clamp recordings from principal neurons medial nucleus trapezoid body showed a rise...
ABSTRACT Aim Modelling African great ape distribution has until now focused on current or past conditions, whilst future scenarios remain scarcely explored. Using an ensemble forecasting approach, we predicted changes in taxon-specific under of climate, land-use and human population changes. Location Sub-Saharan Africa Methods We compiled occurrence data populations from the IUCN A.P.E.S. database extracted relevant human-, climate- habitat-related predictors representing (2050) conditions...
Abstract Aim Modelling African great ape distribution has until now focused on current or past conditions, while future scenarios remain scarcely explored. Using an ensemble forecasting approach, we predicted changes in taxon‐specific under of climate, land use and human populations for (1) areas outside protected (PAs) only (assuming complete management effectiveness PAs), (2) the entire study region (3) interspecies range overlap. Location Tropical Africa. Methods We compiled occurrence...
Kv3 potassium currents mediate rapid repolarisation of action potentials (APs), supporting fast spikes and high repetition rates. Of the four gene family members, Kv3.1 Kv3.3 are highly expressed in auditory brainstem we exploited this to test for subunit-specific roles at calyx Held presynaptic terminal mouse. Deletion (but not Kv3.1) reduced channel immunolabelling, increased AP duration facilitated excitatory transmitter release; which turn enhanced short-term depression during...
Neocortical layer 5 thick-tufted pyramidal cells are prone to exhibiting burst firing on receipt of coincident basal and apical dendritic inputs. These inputs carry different information, with coming from feedforward sensory pathways diverse sources that provide context in the cortical hierarchy. We explore information processing possibilities this using computer simulations a noisy compartmental cell model. Simulated data stochastic due brief, simultaneously injected currents allow...
Presynaptic group III metabotropic glutamate receptor (mGluR) activation by exogenous agonists (such as l ‐2‐amino‐4‐phosphonobutyrate ( ‐AP4)) potently inhibit transmitter release, but their autoreceptor function has been questioned because endogenous during high‐frequency stimulation appears to have little impact on synaptic amplitude. We resolve this ambiguity studying of mGluRs trains stimuli at the calyx Held. In vitro whole‐cell patch recordings were made from medial nucleus trapezoid...
The morphological development of neurons is a very complex process involving both genetic and environmental components. Mathematical modelling numerical simulation are valuable tools in helping us unravel particular aspects how individual grow their characteristic morphologies eventually form appropriate networks with each other. A variety mathematical models that consider (1) neurite initiation (2) elongation (3) axon pathfinding, (4) branching dendritic shape formation reviewed. different...
Key points Synapses have high energy demands which increase during intense activity. We show that presynaptic terminals can utilise extracellular glucose or lactate to generate maintain synaptic transmission. Reducing substrates induces a metabolic stress: ATP depletion impaired transmission through reduction in the number of functional vesicle release sites and slowing pool replenishment, without consistent change probability. Metabolic function is compromised many pathological conditions...
Numerical calculations have been used to assess the performance of three different winners-take-all recall strategies for associative net model heteroassociative memory. Two designed improve when is partially connected or input cues are noisy shown provide significantly greater capacity and information efficiency under these conditions. Estimates made nets that size CA3 region rat hippocampus. These indicate thousands patterns can be stored, with exact number highly dependent on pattern...