A5031121262- RNA Research and Splicing
- Wnt/β-catenin signaling in development and cancer
- Genomics and Chromatin Dynamics
- COVID-19 and Mental Health
- Cancer-related gene regulation
- Disaster Response and Management
University of California, Santa Barbara
2022
Wnt signal transduction is controlled by the destruction complex (DC), a condensate comprising scaffold proteins and kinases that regulate β-catenin stability. Overexpressed DC scaffolds undergo liquid–liquid phase separation (LLPS), but mesoscale organization at endogenous expression levels its role in processing were previously unknown. Here, we find LLPS nucleated centrosome. Through combination of CRISPR-engineered custom fluorescent tags, finite element simulations, optogenetic tools...
Abstract Wnt signal transduction is mediated by a protein assembly called the Destruction Complex (DC) made from scaffold proteins and kinases that are essential for transducing extracellular ligand concentrations to changes in nuclear β-catenin, pathway’s transcriptional effector. Recently, DC have been shown undergo liquid-liquid phase separation vivo vitro providing evidence mesoscale organization of DC. However, at endogenous expression levels how could play role β-catenin processing...
Aims To ensure that the PPE guidance is strictly adhered to. patient care not compromised. help us in areas of need order to educate staff regarding techniques and thus safety during pandemic. Method Novel coronavirus 2019 was first described December Wuhan China. Since those initial few cases, it has rapidly proliferated a global pandemic, putting an inordinate amount strain on healthcare systems around world. We believe technique donning doffing if followed as per PHE guidelines would be...