A5024963500- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Orthopedic Infections and Treatments
- Hip disorders and treatments
- Hip and Femur Fractures
- Shoulder Injury and Treatment
- Orthopedic Surgery and Rehabilitation
- Osteoarthritis Treatment and Mechanisms
- Knee injuries and reconstruction techniques
- Cardiac Valve Diseases and Treatments
- Bone fractures and treatments
- Shoulder and Clavicle Injuries
- Bone Tissue Engineering Materials
- Bone and Joint Diseases
- Surgical Sutures and Adhesives
- Venous Thromboembolism Diagnosis and Management
- Musculoskeletal synovial abnormalities and treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Electrospun Nanofibers in Biomedical Applications
- Exercise and Physiological Responses
- Nail Diseases and Treatments
- Lower Extremity Biomechanics and Pathologies
- Tissue Engineering and Regenerative Medicine
- Stress Responses and Cortisol
- Musculoskeletal pain and rehabilitation
Wrightington Hospital
2015-2024
Wrightington, Wigan and Leigh NHS Foundation Trust
2015-2024
Health Education North West
2004-2024
University of Liverpool
2003-2023
University of Leeds
2022-2023
University of Manchester
1999-2023
Stepping Hill Hospital
2023
Countess of Chester Hospital
2023
Newcastle University
2022-2023
University of Bristol
2022
BackgroundFemoroacetabular impingement syndrome is an important cause of hip pain in young adults. It can be treated by arthroscopic surgery, including reshaping the hip, or with physiotherapist-led conservative care. We aimed to compare clinical effectiveness arthroscopy best care.MethodsUK FASHIoN a pragmatic, multicentre, assessor-blinded randomised controlled trial, done at 23 National Health Service hospitals UK. enrolled patients femoroacetabular who presented these hospitals. Eligible...
Periprosthetic joint infection (PJI) affects approximately 1 % of patients following total hip replacement (THR) and often results in severe physical emotional suffering. Current surgical treatment options are debridement, antibiotics implant retention; revision THR; excision the amputation. Revision surgery can be done as either a one-stage or two-stage operation. Both types well-established practice NHS result similar rates re-infection, but little is known about impact these treatments...
BackgroundApproximately 20% of people experience chronic pain after total knee replacement, but effective treatments are not available. We aimed to evaluate the clinical effectiveness and cost-effectiveness a new care pathway for replacement.MethodsWe did an unmasked, parallel group, pragmatic, superiority, randomised, controlled trial at eight UK National Health Service (NHS) hospitals. People with 3 months replacement surgery were randomly assigned (2:1) Support Treatment After Replacement...
Introduction The purpose of this modified Delphi study was to obtain consensus on wound closure and dressing management in total knee arthroplasty (TKA). Materials Methods panel included 20 orthopaedic surgeons from Europe North America. There were 26 statements identified using a targeted literature review. Consensus developed for the with up three rounds anonymous voting per topic. Panelists ranked their agreement each statement five-point Likert scale. An priori threshold ≥75% required...
Periacetabular osteotomy (PAO) is a surgical procedure to correct acetabular orientation in developmental dysplasia of the hip (DDH). It changes position acetabulum increase femoral head coverage and distribute contact pressure over cartilage surface. The success PAO depends significantly on surgeon's experience. Using computed tomography data from patients with DDH, we developed 3D finite element (FE) model investigate optimal following PAO. A virtual was performed rotated increments...
Fresh-frozen biological allograft remains the most effective substitute for 'gold standard' autograft, sharing many of its osteogenic properties but, conversely, lacking viable cells. Tissue engineering offers opportunity to improve osseointegration this material through addition mesenchymal stem cells (MSCs). However, presence dead, immunogenic and potentially harmful bone marrow could hinder cell adhesion differentiation, graft augmentation incorporation, wash procedures are therefore...
The Revision Hip Complexity Classification (RHCC) provides a framework to allow discussion of complex cases as part local or regional revision hip multidisciplinary team meetings. British Society (BHS) produced RHCC mobile app help simplify the classification process. We aimed test inter-observer and intra-observer reliability both with without use app. Two consultant orthopaedic surgeons, three registrars two practitioners graded 50 consecutive app, on occasions weeks apart. later further...
Abstract Objective To investigate the presence and rates of anxiety depression in postsurgical patients. Methods The Hospital Anxiety Depression Scale was used to measure levels. Patients completed questionnaire on day prior surgery, then each post‐operative up including their discharge. Statistical analysis using logistic regression performed determine whether any variables were risk factors for developing or depression. Fifty‐six patients undergoing lower limb arthroplasty agreed take...
Abstract Osteoarthritis (OA) is characterised by progressive destruction of articular cartilage and chondrocyte cell death. Here, we show the expression endogenous peptide urocortin1 (Ucn1) two receptor subtypes, CRF-R1 CRF-R2, in primary human chondrocytes (AC) demonstrate its role as an autocrine/paracrine pro-survival factor. This effect could only be removed using selective antagonist CP-154526, suggesting Ucn1 acts through when promoting survival. death was increase p53 expression,...
Aims The aim of this study was to investigate whether the use antibiotic-loaded bone cement influenced risk revision surgery after primary total hip arthroplasty (THA) for osteoarthritis. Methods involved data collected by National Joint Registry (NJR) England and Wales, Northern Ireland Isle Man between 1 September 2005 31 August 2017. Cox proportional hazards were used association due prosthetic joint infection (PJI), with adjustments made year initial procedure, age at time surgery, sex,...
Aims This study evaluates risk factors influencing fracture characteristics for postoperative periprosthetic femoral fractures (PFFs) around cemented stems in total hip arthroplasty. Methods Data were collected PFF patients admitted to eight UK centres between 25 May 2006 and 1 March 2020. Radiographs assessed Unified Classification System (UCS) grade AO/OTA type. Statistical comparisons investigated relationships by age, gender, stem fixation philosophy (polished taper-slip (PTS) vs...
Abstract Background We determined the association between frailty and short-term mortality following total hip knee arthroplasty (THA/TKA) for osteoarthritis also impact of THA/TKA on compared with a control population. Methods Frailty was assessed using index (categorised: fit, mild, moderate, severe frailty). The Cox regression. Mortality population but no previous THA/TKA, matched year birth, sex quintile multiple deprivation. Results A 103,563 cases who had THA, 125,367 TKA controls...