A5066347380- Renal Transplantation Outcomes and Treatments
- Paraoxonase enzyme and polymorphisms
- Pharmacological Effects and Toxicity Studies
- Antibiotics Pharmacokinetics and Efficacy
- Adsorption and biosorption for pollutant removal
- Cholinesterase and Neurodegenerative Diseases
- Drug Transport and Resistance Mechanisms
- Transplantation: Methods and Outcomes
- Computational Drug Discovery Methods
- Acute Lymphoblastic Leukemia research
- thermodynamics and calorimetric analyses
- Ancient Mediterranean Archaeology and History
- Pesticide Exposure and Toxicity
- Anesthesia and Pain Management
- Organ Transplantation Techniques and Outcomes
- Ancient and Medieval Archaeology Studies
- Free Radicals and Antioxidants
- Intraocular Surgery and Lenses
- Ocular Surface and Contact Lens
- Biochemical Acid Research Studies
- Analytical Methods in Pharmaceuticals
- Apelin-related biomedical research
- Statistical Methods in Clinical Trials
- Chemical Reaction Mechanisms
- Analytical Chemistry and Chromatography
Hôpital Dupuytren
2004-2024
Université de Limoges
2011-2023
Centre Hospitalier Universitaire de Limoges
2009-2023
Inserm
2009-2020
Service de la Santé Publique
2016
Pharmac
2016
Hôpital Universitaire Dupuytren
1996-2015
Laboratoire de Chimie
1998
Archéologie et Philologie d’Orient et d’Occident
1995
École Normale Supérieure - PSL
1995
The aim of this work is to estimate the area‐under blood concentration curve tacrolimus (TAC) following b.i.d. or q.d. dosing in organ transplant patients, using Xgboost machine learning (ML) models. A total 4,997 and 1,452 TAC interdose area under curves (AUCs) from patients on TAC, sent our Immunosuppressant Bayesian Dose Adjustment expert system ( www.pharmaco.chu‐limoges.fr/ ) for AUC estimation dose recommendation based concentrations measured at least 3 sampling times (predose, ~ 1...
The name of Herbert Freundlich is commonly associated with a power relationship for adsorbed amount substance (Cads) against the concentration in solution (Csln), such that Cads = KCslnn; this isotherm (together Langmuir isotherm) considered to be model choice correlating experimental adsorption data micropollutants or contaminants emerging concern (pesticides, pharmaceuticals, and personal care products), but it also concerns gases on solids. However, Freundlich's 1907 paper was "sleeping...
The aim of this study was to develop maximum a posteriori probability (MAP) Bayesian estimators mycophenolic acid (MPA) pharmacokinetics (PK) capable accurately estimating the MPA interdose AUC in renal transplant patients using limited number blood samples. individual plasma concentration-time profiles 44 adult kidney recipients were retrospectively studied: 24 de novo patients, 2 obtained on day 7 and 30 after transplantation, 20 stable 1 profile period (>3 months). assayed by liquid...
Therapeutic drug monitoring of mycophenolic acid (MPA) based on area under the curve (AUC) is well‐established and machine learning (ML) approaches could help to estimate AUC. The aim this work AUC MPA in organ transplant patients using extreme gradient boosting (Xgboost R package) ML models. A total 12,877 from 0 12 hours (AUC 0–12 h ) requests 6,884 sent our Immunosuppressant Bayesian Dose Adjustment expert system ( https://abis.chu‐limoges.fr for estimation dose recommendation...
Experimental equilibrium data for the adsorption of water contaminants on solid surfaces are generally correlated using suitable isotherm expressions. In most cases, isotherms used empirically with primary aim finding best fitting ones. The literature adsorptive decontamination is replete such comparisons, usually evaluated basis some statistical metrics as R2 and RMSE. For example, several studies have compared ranked equations Hill, Sips, Koble–Corrigan, Liu. These comparative evaluations...
The once-daily formulation of tacrolimus has been reported to exhibit the same efficacy and safety profile as compared with immediate-release form administered twice daily. However, a result differences in their pharmacokinetic (PK) profile, PK models or Bayesian estimators (MAP-BE) previously developed for cannot be used new formulation. Using information obtained from Phase II trial, aim this study was explore feasibility developing model MAP-BE able estimate, on basis routinely applicable...
We report a feasibility study based on our large-scale experience with mycophenolate mofetil dose adjustment mycophenolic acid interdose area under the curve (AUC) in renal transplant patients.Between 2005 and 2010, 13,930 requests for 7090 different patients (outside any clinical trial) were posted by more than 30 transplantation centers free, secure web site recommendations using three plasma concentrations Bayesian estimation.This retrospective showed that 1) according to consensually...
Tacrolimus (TAC) is the cornerstone of immunosuppressive therapy in liver transplantation. This study aimed at elucidating interplay between pharmacogenetic determinants TAC whole blood and intracellular exposures as well pharmacokinetic-pharmacodynamic relationship both compartments. Complete pharmacokinetic profiles (Predose, 20 min, 40 1h, 2h, 3h, 4h, 6h, 8h, 12h post drug intake) twice daily peripheral mononuclear cells (PBMC) were collected 32 transplanted patients first ten days A...
The Flory–Huggins (FH) isotherm first appeared in the literature of water contaminant adsorption mid-2000s. It has come into limelight and received considerable attention recent years, large part due to regular coverage review articles. Here, we point out that a linear form FH is incompatible with original nonlinear version. We show conclusively was destroyed beyond recognition by linearization method. As result, linearized suffers from following serious defects: (1) Its parameter estimates...
A bstract : Paraoxonase 1 (PON1), an A‐esterase with peroxidase‐like activity present on the surface of HDL, decreases peroxidation LDL. Serum PON1 (PON1a) aging and in disorders associated a high risk adverse cardiovascular events (acute myocardial infarction, diabetes mellitus, chronic renal failure). The implication vascular factors Alzheimer‐type dementia (ATD) is strongly suspected. We measured PON1a by spectrophotometry using paraoxon substrate 180 healthy subjects (controls; mean age:...
An esterase, paraoxonase 1 (PON1), protects against organophosphate neurotoxicity and decreases lipoprotein oxidation. Two polymorphisms of PON1 [192 (R or Q) 55 (M L)] exist are associated with coronary artery disease. We have previously shown that serum activity (PON1a) is lower in vascular dementia (VaD) than Alzheimer's disease (AD), suggesting PON1a may distinguish VaD from AD. As polymorphism modifies PON1a, we determined 192 by sequence-specific primer PCR 64 healthy subjects (HS;...