A5047942138- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Cardiac Ischemia and Reperfusion
- Inflammatory mediators and NSAID effects
- Retinoids in leukemia and cellular processes
- Retinal Diseases and Treatments
- Estrogen and related hormone effects
- Phytochemicals and Antioxidant Activities
- Systemic Sclerosis and Related Diseases
- Vitamin C and Antioxidants Research
- Phytochemistry and biological activity of medicinal plants
- Genetic factors in colorectal cancer
- Per- and polyfluoroalkyl substances research
- Lipid metabolism and disorders
- Cassava research and cyanide
- Biological Research and Disease Studies
- Bipolar Disorder and Treatment
- Curcumin's Biomedical Applications
- Effects of Radiation Exposure
- Synthesis and properties of polymers
- Kruppel-like factors research
- Apelin-related biomedical research
- Tea Polyphenols and Effects
- Retinal Development and Disorders
- Neonatal and Maternal Infections
Mersin Üniversitesi
2011-2024
Massachusetts Eye Research and Surgery Institute
2022-2023
Cukurova University
2004-2016
Ministry of Health
2013
Hemoglobinopathies are the most common genetic disorders in Turkey. The incidence of beta thalassemia and sickle cell trait (HbAS) is 2.0% 0.3% respectively. In addition to HbS, 51 abnormal hemoglobins 42 different mutations have been detected by DNA analysis. Turkey, anemia cause major health problems. For thirty years, screening programs for carriers, counseling prenatal diagnosis sought prevent hemoglobinopathies. 1983, first center was established at Hacettepe University, Ankara. After...
Purpose: Although radiotherapy (RT) is an important component of cancer treatment, it induces adverse tissue reactions in the around tissue. Therefore, radioprotectives are needed to protect normal tissues. The aim this study was investigate radioprotective effect N-acetylcysteine (NAC) on RT-induced cardiac damage rats for acute term.Materials and methods: animals were divided into four groups. control group injected with saline 7 d; NAC at dose 240 mg/kg d RT plus irradiated 1 h after last...
To contribute to the creation of a mutation map region, we aimed determine spectrum thalassemias and abnormal hemoglobins (Hbs) in Çukurova region surrounding provinces. In this study, total 8135 samples from Adana, Hatay, Mersin, Konya Kayseri provinces between 1993 2014 were analyzed. Complete blood cell (CBC) counts Hb typing carried out using automatic counters, cellulose acetate membrane electrophoresis high performance liquid chromatography (HPLC), respectively. For molecular analyses,...
Myeloid differentiation primary response gene 88 (MyD 88) is an intracellular adapter protein that mediates the early immune to pathogens. Toll-like receptors (except TLR-3) induce through a MyD 88-dependent signal pathway.We aimed investigate polymorphisms play important roles in septic children and evaluate whether or not they were risk factors development of sepsis.Case-control study.Sixty-five patients diagnosed with sepsis Pediatric Intensive Care Unit during period from April 2010...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Yukseloglu E, Celik S, Kucuk M, et al. IRS-2 G1057D polymorphism in Turkish patients with colorectal cancer. Gastroenterology Review/Przegląd Gastroenterologiczny. 2014;9(2):88-92. doi:10.5114/pg.2014.42503. APA Yukseloglu, E., Celik, S., Kucuk, M., Yalin, Ozkal, & Ates, C. (2014). Gastroenterologiczny, 9(2), 88-92. https://doi.org/10.5114/pg.2014.42503 Chicago Emel Hulya, Sevim Karakas Meral Urhan Erdinc S....
Objective: Environmental exposure to deltamethrin can cause alterations in structure and function of different organs. F. Trogii, a white-rot fungus, has antioxidative enzymes such as superoxide dismutase, catalase glutathione reductase. It is hypothesized that there an role trogii resulting reducing the extent heart injury result oxidative stress. The aim this study investigate effect on evaluate possible protective alleviating detrimental heart. Materials Methods: Twenty-one adult albino...
Attention deficit hyperactivity disorder (ADHD) is a heterogeneous, highly heritable, common childhood neurobehavioural resulting from complex gene-gene and gene-environment interactions. The erythropoietin (Epo)/erythropoietin receptors (EpoR) system turned out to have additional important functions in nonhematopoietic tissue. In this study, we aimed investigate the levels of Epo EpoR, also their diagnostic values children with ADHD.A total 70 were included 35 drug-naive patients ADHD (age:...
Pomegranate is a rich source of many polyphenolic compounds including ellagitannins (punicalagin, punicalin and others).The effects punicalagin on adipogenesis were investigated in this study.To examine the effect adipocyte differentiation, various concentrations (2-10 µM) applied to differentiated 3T3-L1 cells. Glyceraldehyde-3-phosphate dehydrogenase (GPDH) activity, Oil red O staining, intracellular triglyceride levels, gene expressions transcription factors (Peroxisome...
Amaç: Bu çalışmada stres ve menopozun birlikte, öğrenme işlevi üzerindeki etkileri araştırılmıştır. Yöntem: Çalışmada, 60 adet dişi Wistar-Albino sıçan kullanılmıştır. sıçanlar randomize olarak kontrol (Grup I), deneysel immobilizasyon modeli II), menopoz III) + IV) olmak üzere her bir grupta 15’er hayvan bulunan 4 gruba ayrılmıştır. Tüm sıçanların uzun dönemdeki bilişsel motor yetileri davranış deneyleri (açık alan Morris su tankı) ile değerlendirilmiştir. Ayrıca hipotalamus-hipofiz-adrenal...
Purpose: In this study, the effects of three different single nucleotide polymorphisms (rs249954, rs249935, and rs16940342) partner localizer breast cancer gene 2 (PALB2) on predisposition have been investigated. Materials Methods: For purpose, 150 patients diagnosed to healthy individuals included. By using real time polymerase chain reaction (PCR) method isolated deoxyribonucleic acid (DNA) from each case has investigated for PALB2 genetic variations. Results: The distribution homozygote...
Amaç: Hedeflenmemiş antikanser ilaçlardan kaynaklı oksidatif stres çeşitli dokularda kardiyotoksisite, nörotoksisite ve hepatotoksisite gibi önemli yan etkilere neden olmaktadır. Paklitaksel, solid tümörlerin tedavisinde kullanılan taksan türevi kemoterapötik biridir. Bu tür kemoterapötiklerin sinir hasarı oluşturduğu bilinmektedir. Çaydabulunan kateşinlerin en aktif bileşeni olan epigallokateşin gallat (EGCG) bir antioksidan olup, DNA stabilitesinin sağlanılması sağlıklı yaşamda role...
The highly polymorphic minisatellites contain a variable number of tandemly repeated (VNTR) DNA sequences. They are extremely useful and informative markers to study genetic variation among human populations. We have analysed the allele frequency distribution at apolipoprotein B (Apo B) VNTR locus in order obtain population data for Cukurova region Turkey by using polymerase chain reaction polyacrylamide gel electrophoresis. observed 10 different alleles 21 genotypes sample 100 unrelated...