Alzheimer's disease is a heterogenous disorder with multiple phenotypes and genotypes, although they eventually converge to final common clinicopathological endpoint. However, drug trials do not account for the heterogeneity of in trial design, impeding development effective drugs.Alzheimer's commonly have wide inclusion criteria that subsume subtypes condition, varying phenotypes, clinical courses. The outcome variables used many may be sensitive particular subtype follow patients...

Objectives: To compare the sensitivity and specificity of clinical diagnosis Alzheimer disease, distribution pathological causes, demographic characteristics 2 different groups patients with dementia.Design: Retrospective clinicopathological study.Setting: A memory disorder clinic in a university hospital multiethnic community.Patients: Sixty-three from 26 large community-based study who underwent autopsy after evaluation.Main Outcome Measures: Differential findings, correlations.Results:...

To determine the neuropathological diagnoses of longitudinally followed patients with potentially reversible causes dementia and to examine results "dementia work-up," especially neuroimaging, by comparison pathological diagnosis.A neuropathologic series 61 consecutive patients, review clinical, laboratory, results.Of forty-eight (79%) had a clinical diagnosis probable or possible Alzheimer's disease (AD). Compared diagnosis, sensitivity specificity AD were 96% 79%, respectively. Of 9...

Interview with Dr. Gayatri Devi on assessment and support for physicians Alzheimer’s disease. (10:54)Download Policies are needed to aid the increasing numbers of working health care professionals who have disease, while safeguarding their communities. The emphasis should be supporting, not penalizing, impaired physicians.

OBJECTIVE: Both early-onset Alzheimer’s Disease (EOAD) and late-onset (LOAD) present with cognitive psychiatric features. Some studies suggest that EOAD patients are more likely than LOAD to have symptoms. If this is true, relatives of a similar clinical presentation may be misclassified as having primary noncognitive disorder rather dementing disorder. Family history underestimate familial aggregation EOAD. METHODS: The authors compared the presence symptoms in parents siblings 131...

We examined 180 siblings of 127 probands with probable or possible Alzheimer's dementia (AD) in a family study AD. The overall sensitivity simple history questionnaire was 64% and the specificity 84%. Sensitivity improved 90–100% minimal decline when we considered clinic-based vs. Population survey patients. Higher education among informants availability spouse sibling as informant significantly increased sensitivity. Awareness such factors may improve yield AD using questionnaire. Genet....

<b><i>Objective:</i></b> To examine the influence of proband's <i>APOE</i> genotype on AD among first-degree relatives in a community-based study African Americans, whites, and Caribbean Hispanics. <b><i>Methods:</i></b> History demographic information were obtained 1,073 siblings parents 312 patients with 2,722 802 nondemented controls. genotyping was performed all 1,114 <b><i>Results:</i></b> A higher proportion (35%) than controls (27%) had one or more<i> APOE</i>-ε4 alleles (<i>p</i> =...

Identifying the cognitive changes associated with menopausal transition prevents misattribution of symptoms to more ominous causes such as neurodegenerative disease.Two women loss and objective evidence menopause-related impairment are presented, misattributed Alzheimer disease in one case frontotemporal dementia other. Neurocognitive testing, neuroimaging, laboratory findings reviewed. Both were diagnosed stable follow-up over 4 or years.Recognizing menopause distinguishing from resulting...

Aging physicians are at a higher risk of cognitive impairment, undermining patient safety and unraveling physicians' careers. Neurologists, occupational health physicians, psychiatrists will participate in both system policy decisions individual evaluations. We address impairment aging attendant risks benefits. If significant is found after an appropriate evaluation, precautions to confidentially support practicing safely for as long possible should be instituted. Understanding that there...

Objective The results of the Women’s Health Initiative studies dramatically altered hormone therapy use around world. In countries outside United States, self-use in physicians remained unaltered while prescription declined, implying that may not concur with findings. We wished to explore prevailing attitudes among American by examining New York City obstetrician-gynaecologists’ and therapy. Study design All board-certified obstetrician-gynaecologists were invited complete return a detailed,...

Uterine prolapse in pregnancy is uncommon pregnancy. It can be preexistent or else manifest course of During usually associated with adverse outcomes such as vaginal infection, cervical ulceration and preterm delivery. A22-year-old Smt.X, married for 2 ½ Years, presented to obstetric OP complaint mass per vaginum pain abdomen. Her LMP was 19/09/2023 EDD 26/06/2024.Her cycles are regular 5/30 days cycle. formula G2P1L1.She diagnosed grade 3 uterovaginal descent months after rst We treated...

ABSTRACT Introduction: The simultaneous occurrence of cancer and pregnancy is an uncommon medical scenario can pose a diagnostic treatment challenge. Of malignancies diagnosed during pregnancy, hematologic rank second in the most prevalent neoplasms, after breast cancer, with Hodgkins Lymphomas (HL) Non-Hodgkins (NHL) comprising nearly 6% 5%, respectively. Case Presentation: A 28-year-old- female, Primigravidae 39 weeks gestational age Lymphoma came to antenatal OPD at Government Maternity...

Summary Little is known about the person behind eponymous dementia, Alois Alzheimer. We wished to study his life and contributions field of neuroscience. All cited articles Alzheimer by contemporaries selected correspondence him was translated from German. Additional personal information obtained granddaughter. made seminal neuroscience, not only through own research but also numerous scientists physicians whom he taught. His a lasting impact in area disease other aspects brain disease. In...