A5101997149- Molecular Biology Techniques and Applications
- Forensic and Genetic Research
- Genomics and Phylogenetic Studies
- Geotechnical Engineering and Soil Stabilization
- Cytokine Signaling Pathways and Interactions
- Innovative concrete reinforcement materials
- Genetic Associations and Epidemiology
- Colorectal Cancer Treatments and Studies
- Nanoplatforms for cancer theranostics
- Chromosomal and Genetic Variations
- Recycled Aggregate Concrete Performance
- Environmental DNA in Biodiversity Studies
- Dementia and Cognitive Impairment Research
- Isotope Analysis in Ecology
- MicroRNA in disease regulation
- Neonatal Health and Biochemistry
- Genomics and Rare Diseases
- Ion channel regulation and function
- Nanoparticle-Based Drug Delivery
- Microbial Community Ecology and Physiology
- Advanced Nanomaterials in Catalysis
- Cardiac electrophysiology and arrhythmias
- Functional Brain Connectivity Studies
- 3D Printing in Biomedical Research
- Genetic diversity and population structure
Xi'an Technological University
2024-2025
Tianjin Medical University
2024
Tianjin University
2024
First Affiliated Hospital of Soochow University
2021-2024
Soochow University
2021-2024
Terasaki Foundation
2022
West China Medical Center of Sichuan University
2018-2020
Sichuan University
2017-2018
University College London
2018
China Medical University
2015
Colorectal cancer (CRC) is the third most common type of cancer, and its incidence mortality are markedly increasing worldwide. Oncogenic mutations KRAS occur in up to 40% CRC cases pose a great challenge treatment disease. Quercetin dietary flavonoid that exerts anti-oxidant, anti-inflammatory, anti-cancer properties. The current study investigated anti-proliferative effect quercetin on cells harboring mutant or wild-type KRAS. cell viability was by MTT colony formation assays, apoptosis...
Catalytic therapy has shown great potential for clinical application. However, conventional catalytic therapies rely on reactive oxygen species (ROS) as "therapeutic drugs," which have limitations in effectively inhibiting tumor recurrence and metastasis. Here, a biomimetic heterojunction catalyst is developed that can actively target orthotopic rectal cancer after oral administration. The composed of quatrefoil star-shaped BiVO
As a building material, recycled concrete (RC) has significant advantages in environmental protection and sustainable development. In the cold conditions of northwest China, order to maintain toughness durability buildings during service, polyacrylonitrile fiber (PANF) is often used as toughening agent with RC. this study, mechanical tests frost were conducted on fiber-reinforced (PAN-RC). The mixing contents PANF 0.7 kg/m3, 0.8 0.9 while substitution rates coarse aggregate (RCA) 30%, 40%,...
Abstract Insertion/deletion polymorphisms (InDels), which possess the characteristics of low mutation rates and a short amplicon size, have been regarded as promising markers for forensic DNA analysis. InDels can be classified bi‐allelic or multi‐allelic, depending on number alleles. Many studies explored use in applications, such individual identification ancestry inference. However, multi‐allelic received relatively little attention. In this study, with 2–6 alleles minor allele frequency...
Individuals with subjective cognitive decline (SCD) are more likely to develop into Alzheimer disease (AD) in the future. Resting-state functional magnetic resonance imaging (rs-fMRI) studies have shown alterations of intrinsic brain activity (IBA) SCD individuals. However, rs-fMRI date mainly focused on static characteristics IBA, few reporting dynamics- and concordance-related changes IBA indices To investigate these aberrant changes, a temporal dynamic analysis data was conducted 94...
// Po-Chang Shih 1 , Yiwen Yang Gary N. Parkinson Andrew Wilderspin and Geoffrey Wells UCL School of Pharmacy, University College London, Bloomsbury, London WC1N 1AX, UK Correspondence to: Wells, email: g.wells@ucl.ac.uk Keywords: STAT3; signal transducer activator transcription; high-throughput; DNA-binding domain; fluorescence polarization Received: March 27, 2018 Accepted: July 31, Published: August 24, ABSTRACT Anti-cancer drug discovery efforts to directly inhibit the transcription 3...
Glioma is the most common primary malignant tumor in brain. The diagnostic accuracy and treatment efficiency of glioma are facing great challenges due to presence blood-brain barrier (BBB) high infiltration glioma. There an urgent need explore combination therapeutic approaches achieve a more accurate diagnosis, as well guidance before after surgery. In this work, we induced human induction pluripotent stem cell into neural progenitor cells (NPCs) synthesized nanoprobes labeled with enhanced...
Long QT syndrome (LQTS) is a genetic cardiac disease. Gene mutation affects the structure or function of ion channels that are associated with high risk sudden death. The goal this study was to determine frequency KCNQ1, KCNH2, and SCN5A mutations in LQTS Taiwanese population. Genomic DNA extracted from peripheral blood samples obtained 5 patients family members 3 patients. High resolution melting (HRM) analysis direct sequencing were used characterize variations. HRM successfully optimized...
To assess the association of programmed cell death 1 (PDCD1) gene polymorphisms with susceptibility and/or progression colorectal cancer.A hospital-based case-control study was carried out, which recruited 426 cancer patients and 500 healthy individuals. Five single nucleotide polymorphisms, namely rs36084323, rs11568821, rs2227981, rs2227982 rs10204525, were selected for genotyped a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay.The G allele rs36084323...
<title>Abstract</title> The recycling of concrete is environment-friendly and contributes to the sustainable development strategy. Recycled can achieve better compressive strength, but there are deficiencies in tensile frost durability. Then, polyacrylonitrile fiber be used as a toughening component due its good properties such high ultimate elongation, etc., which endow recycled with higher toughness maintain under altitude cold conditions. In this study, mechanical tests durability were...
Objective To select and develop a SNP-STR multiplex amplification system with genetic markers compatible current STR databases. understand its polymorphisms in Sichuan Han population application value DNA mixture analysis. Methods Based on the commercial kits, SNPs adjacent to these were selected be markers. A based allele-specific was constructed using primers. The polymorphism of investigated efficiency systems different numbers loci detect two individual samples evaluated. Results An...
Short tandem repeats on the Y chromosome (Y-STRs), characterized by paternal inheritance, are valuable in forensic practice. Notably, potential application of Y-STRs pedigrees should be drawn upon, especially China's surname-concentrated natural villages. The study focused 50 Y-STRs, including 13 rapidly mutating (RM) that largely constitute current Y-STR commercial kits, and determined differences these between branches a large pedigree discriminatory power haplotypes different units for...