A5011763215- Forensic and Genetic Research
- Molecular Biology Techniques and Applications
- Genetic diversity and population structure
- Genetic Associations and Epidemiology
- Genomics and Phylogenetic Studies
- Environmental DNA in Biodiversity Studies
- Cancer-related molecular mechanisms research
- Forensic Anthropology and Bioarchaeology Studies
- Genetics, Bioinformatics, and Biomedical Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- RNA and protein synthesis mechanisms
- Archaeology and ancient environmental studies
- Bacteriophages and microbial interactions
- Photosynthetic Processes and Mechanisms
- Genetic factors in colorectal cancer
- Genetic Mapping and Diversity in Plants and Animals
- Epigenetics and DNA Methylation
- Wildlife Ecology and Conservation
- Metabolomics and Mass Spectrometry Studies
- Health Systems, Economic Evaluations, Quality of Life
- Chromosomal and Genetic Variations
- Pleistocene-Era Hominins and Archaeology
- Biosensors and Analytical Detection
- Rangeland Management and Livestock Ecology
- Yersinia bacterium, plague, ectoparasites research
West China Medical Center of Sichuan University
1997-2024
Sichuan University
2023-2024
West China Hospital of Sichuan University
2023-2024
Abstract Large-scale genomic projects and ancient DNA innovations have ushered in a new paradigm for exploring human evolutionary history. However, the genetic legacy of spatiotemporally diverse Eurasians within Chinese paternal lineages remains unresolved. Here, we report an integrated Y-chromosome database encompassing 15,563 individuals from both modern Eurasians, including 919 newly reported individuals, to investigate diversity. The high-resolution, time-stamped phylogeny reveals...
Complex demographic processes and natural selection pressures are critical to resolving patterns of the molecular genetic basis adaptative traits or complex diseases. Recent ancient genome data allow us trace how key evolved in different human populations over time, connecting population history with disease susceptibility western Eurasians. To fill this gap eastern Eurasians provide deep insights into evolutionary population-specific biological traits, we explored one integrative modern...
Tibeto-Burman (TB) people have endeavored to adapt the hypoxic, cold, and high-UV high-altitude environments in Tibetan Plateau complex disease exposures lowland rainforests since late Paleolithic period. However, full landscape of genetic history biological adaptation geographically diverse TB-speaking people, as well their interaction mechanism remain unknown. We generate a whole-genome meta-database 500 individuals from 39 populations East Asia Southeast present comprehensive diversity,...
Abstract Background Ancient northern East Asians (ANEA) from the Yellow River region, who pioneered millet cultivation, play a crucial role in understanding origins of ethnolinguistically diverse populations modern China and entire landscape deep genetic structure variation discovery Asians. However, direct links between ANEA geographically proximate populations, as well biological adaptive processes involved, remain poorly understood. Results Here, we generated genome-wide SNP data for 264...
Abstract The large-scale human genome revolution and rapidly advanced statistical innovation have updated our understanding of the fine-scale complex genetic structure, entire landscape diversity evolutionary trajectories spatiotemporally different ancients ethnolinguistically diverse modern populations. Recent ancient DNA research provided a detailed admixture picture Europeans but limited insights into East Asians as few available genomes. Y-chromosome variations in male-specific regions,...
Abstract Ancient DNA advances have reported the complex genetic history of Eurasians, but how knowledge ancient subsistence strategy shifts and population movements influenced fine-scale paternal structure in East Asia has not been assessed. Here, we one integrated Y-chromosome genomic database 15,530 people, including 1753 people newly-reported 919 individuals genotyped using our recently-developed targeted sequencing YHSeqY3000 panel, to explore Chinese diversity, evolutionary tracts their...
SUMMARY Tibeto-Burman (TB) people have tried to adapt the hypoxic, cold and high-UV high-altitude Tibetan Plateau complex disease exposure in lowland wet hot rainforest since late Paleolithic period. However, full landscape of genetic history biological adaptation geographically diverse TB their interaction mechanism remained unknown. We generated a whole-genome-based meta-database 500 individuals from 39 populations East Asia Southeast presented comprehensive diversity, admixture...
Abstract CE is the primary methodology used in forensic DNA typing. Alleles of commonly types genetic markers could be separated and detected via based on dye color migration time. Insertion/deletion (InDel) an ideal marker for analysis due to their abundance human genome, low mutation rate, availability allele CE, elimination stutter peaks. Moreover, InDels as ancestry informative since frequencies different among geographically populations. Several insertion/deletion panels have been...
In forensic genetics, the use of ancestry informative single-nucleotide polymorphisms (AISNPs) panels can narrow direction investigation by estimating an individual's biogeographic ancestry. However, distinguishing subgroups within continental regions requires more specific panels. this study, we screened 19 AISNPs from 1000 Genomes Project (1KG) based on their FST values to distinguish target populations in East Asia and obtained genotypes through SNaPshot. The could divide global...
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High-quality genomic datasets from under-representative populations are essential for population genetic analysis and medical relevance. Although the Tujia most populous ethnic minority in southwestern China, previous studies have been fragmented only partially reveal their diversity landscape. The understanding of fine-scale structure potentially differentiated biological adaptive features remains nascent.
The genetic structure differences in population is one of the key elements medical research involving multi-population samples. A set ancestry-informative single nucleotide polymorphisms (AI-SNPs) can be utilized to analyze component a population, infer ancestral origin individuals and pre-filter samples reduce impact on research. However, most published studies were focused revealing between populations continents or regions continent. In this paper, AI-SNPs screened by calculating FST...
Because of its excellent monodispersity, high throughput, and low volume, microfluidics-based droplet PCR has become the core technology digital PCR, next-generation sequencing, other platforms. This study constructed a microfluidic water-in-oil system amplified commercially available forensic 22-plex short tandem repeat detection system. We analyzed sensitivity, concordance, amplification efficiency influence factors above aspects. The showed concordance with conventional bulk had...
Human Pangenome Reference Consortium (HPRC) and Chinese (CPC) have pronounced the finish of pilot work Project, which aimed to build worldwide population-representative high-quality haplotype-resolved reference graph genomes. Graph-based gapless pangenome genomes with enriched genomic diversity higher completeness contiguity possessed potential for a new beginning third-generation sequencing (TGS)-based research high-performance mapping rate variant genotyping traditional short-read...