A5009973108- Cell Adhesion Molecules Research
- Biochemical Acid Research Studies
- Fatty Acid Research and Health
- Protease and Inhibitor Mechanisms
- TGF-β signaling in diseases
- Caveolin-1 and cellular processes
- Hormonal Regulation and Hypertension
- HER2/EGFR in Cancer Research
- Neurotransmitter Receptor Influence on Behavior
- Seaweed-derived Bioactive Compounds
- Cannabis and Cannabinoid Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer, Hypoxia, and Metabolism
- RNA Interference and Gene Delivery
- RNA regulation and disease
- Neuroscience and Neuropharmacology Research
- Nerve injury and regeneration
- Glycosylation and Glycoproteins Research
- Eicosanoids and Hypertension Pharmacology
- Neuroscience and Neural Engineering
- Peroxisome Proliferator-Activated Receptors
Universidad Andrés Bello
2021-2023
Institute of Biomedical Science
2023
Pontificia Universidad Católica de Chile
2012-2021
Vanderbilt University Medical Center
2007
Vanderbilt University
2006
Brain-derived neurotrophic factor (BDNF) and its receptors tropomyosin kinase receptor B (TrkB) the p75 neurotrophin (p75) are primary regulators of dendritic growth in CNS. After being bound by BDNF, TrkB endocytosed into endosomes continue signaling within cell soma, dendrites, axons. We studied functional role BDNF axonal cortical neurons derived from different transgenic mice using compartmentalized cultures microfluidic devices. found that increased neuronal body a cAMP response...
Integrins control many cell functions, including generation of reactive oxygen species (ROS) and regulation collagen synthesis. Mesangial cells, found in the glomerulus kidney, are able to produce large amounts ROS via NADPH oxidase. We previously demonstrated that integrin α1-null mice develop worse fibrosis than wild-type following glomerular injury this is due, part, excessive production by mesangial cells. In present studies, we describe mechanism whereby cells ROS. Integrin have...
The peroxisomal proliferator-activated nuclear receptor-alpha (PPARalpha), the target for most hypolipidemic drugs in current clinical use, regulates transcription of genes involved lipid metabolism and transport, energy homeostasis. More recently, PPARalpha its ligands have been implicated inflammatory responses regulation cell proliferation. also expression Cyp4a fatty acid omega-hydroxylases Cyp2c arachidonic epoxygenase genes. To study role receptor gene tumorigenesis, we treated mice...
Abstract The collagen IV binding receptor integrin α1β1 has been shown to regulate lung cancer due its proangiogenic properties; however, it is unclear whether this also plays a direct role in promoting primary tumors. To investigate possibility, α1-null mice were crossed with KrasLA2 that carry an oncogenic mutation of the Kras gene (G12D) and develop spontaneous tumors features non–small cell cancer. We provide evidence KrasLA2/α1-null have decreased incidence longer survival compared...
The biomedical potential of the edible red seaweed Agarophyton chilense (formerly Gracilaria chilensis) has not been explored. Red seaweeds are enriched in polyunsaturated fatty acids and eicosanoids, which known natural ligands PPARγ nuclear receptor. is molecular target thiazolidinediones (TZDs), drugs used as insulin sensitizers to treat type 2 diabetes mellitus. Medical use TZDs limited due undesired side effects, a problem that triggered search for selective modulators (SPPARMs) without...
Abstract 4‐Methylthioamphetamine ( MTA ) is a phenylisopropylamine derivative whose use has been associated with severe intoxications. usually regarded as selective serotonin‐releasing agent. Nevertheless, previous data have suggested that its mechanism of action probably involves catecholaminergic component. As little known about dopaminergic effects this drug, in work the actions upon dopamine DA transporter DAT were studied vitro , vivo and silico . Also, possible abuse liability was...
Abstract The biomedical potential of the edible red seaweed Agarophyton chilense (former Gracilaria chilensis ) has not been explored. Red seaweeds are enriched in polyunsaturated fatty acids and eicosanoids, which known natural ligands PPARγ nuclear receptor. is molecular target thiazolidinediones (TZDs), drugs used as insulin sensitizers to treat type 2 diabetes mellitus. TZDs medical use limited due undesired side effects, fact that it triggered search for partial agonists without...