A5034718591- Advanced biosensing and bioanalysis techniques
- Electrochemical Analysis and Applications
- Molecular Junctions and Nanostructures
- Biosensors and Analytical Detection
- Nanoparticle-Based Drug Delivery
- Spectroscopy Techniques in Biomedical and Chemical Research
- Nanopore and Nanochannel Transport Studies
- Gold and Silver Nanoparticles Synthesis and Applications
- Analytical Chemistry and Sensors
- Nanocluster Synthesis and Applications
- Spectroscopy and Chemometric Analyses
- RNA Interference and Gene Delivery
- Advanced Biosensing Techniques and Applications
- Bacterial Genetics and Biotechnology
- Meat and Animal Product Quality
- DNA and Nucleic Acid Chemistry
- RNA and protein synthesis mechanisms
- Electrochemical sensors and biosensors
- Bacterial biofilms and quorum sensing
- Water Quality Monitoring and Analysis
- MicroRNA in disease regulation
- Antibiotic Resistance in Bacteria
UNSW Sydney
2013-2018
The University of Sydney
2016
Alzahra University
2010
Bacterial resistance to conventional antibiotics necessitates the identification of novel leads for infection control. Interference with extracellular phenomena, such as quorum sensing, DNA integrity and redox active metabolite release, represents a new frontier control human pathogens Pseudomonas aeruginosa hence reduce mortality. Here we reveal that virulence factor pyocyanin produced by P. binds directly deoxyribose-phosphate backbone intercalates nitrogenous base pair regions. Binding...
The requirement of a wire to each electrode is central the design any electronic device but can also be major restriction. Herein it shown how electrodes connected using light such that multielectrode requires only single physical wire.
Abstract Herein, we study the effect of interfacial design, specifically orientation a DNA probe strand, length diluent and type target (DNA vs. microRNA), on electrochemical response from methylene blue (MB) at low‐density films. The interfaces are formed mixed self‐assembled monolayers single‐stranded (ss‐DNA) hydroxyl terminated alkanethiol diluents gold surfaces. Variation in current DNA–MB complex after hybridization with complementary single adenine–cytosine mismatch is shown to depend...
Abstract Integrating loop-mediated isothermal amplification (LAMP) with capacitively coupled contactless conductivity detection (C 4 D), we have developed an electrical sensor for the simultaneous and of specific sequence DNA. Using O26- wzy gene as a model, amount initial target could be determined via threshold time obtained by monitoring progression LAMP reaction in real time. optimal conditions, limit 12.5 copy/μL can within 30 min. Monitoring C D has not only all advantages that...
Electrochemical DNA biosensors composed of a redox marker modified nucleic acid probe tethered to solid electrode is common experimental construct for detecting and RNA targets, proteins, inorganic ions, even small molecules. This class generally relies on the binding-induced conformational changes in distance relative surface such that charge transfer altered. The conventional design attach species distal end surface-bound strand. Here we show impact position marker, whether or proximal...
Abstract Gold‐coated magnetic nanoparticles (Au@MNPs) have attracted significant interest in electrochemistry recent years. This is especially the case with their application as dispersible electrodes where modified Au@MNPs are dispersed into a solution, selectively bind to analyte of and then brought an electrode via field for measurement. paper characterizes four types different sizes, shapes, method synthesis electrodes. The were characterized by transmission electron microscopy X‐ray...
The influence of RNA versus DNA on the performance electrochemical biosensors where redox-labelled nucleic acid duplexes bend towards electrode surface has been assessed. Faster electron transfer was observed for containing RNA, suggesting with are more flexible. These data particular importance microRNA biosensors.
Light can be used to spatially resolve electrochemical measurements on a semiconductor electrode. This phenomenon has been explored detect DNA hybridization with light-addressable potentiometric sensors and, more recently, amperometric based organic-monolayer-protected Si(100). Here, contribution the field is presented by comparing sensing performances when bovine serum albumin (BSA) and hexaethylene glycol (OEG6) are employed as antifouling layers that resist nonspecific adsorption...
Abstract We provide complex capacitance studies which show that the tethering of negatively‐charged DNA molecules to p‐doped silicon (111), without intervening oxide layer, leads changes electric field in underlying silicon. proposed, formation surface states that, from electronic point view, resemble major carriers p‐type silicon, i.e. holes. This effect is enhanced by double‐stranded (ds)DNA and hence premise label‐free detection hybridization. Overall, our a promising alternative design...
Abstract Review: 115 refs.