A5072362767- Hepatocellular Carcinoma Treatment and Prognosis
- Peptidase Inhibition and Analysis
- Carbohydrate Chemistry and Synthesis
- Organ Transplantation Techniques and Outcomes
- Neuropeptides and Animal Physiology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Security, Politics, and Digital Transformation
- Nerve injury and regeneration
- Cancer Research and Treatments
- Enzyme Catalysis and Immobilization
- International Science and Diplomacy
- Liver physiology and pathology
- Neuroblastoma Research and Treatments
- Nanoparticle-Based Drug Delivery
- Legume Nitrogen Fixing Symbiosis
Leiden University Medical Center
2022-2024
University of Bristol
2022
A new practical, catalytic, and highly stereoselective method for directly accessing 1,1-α,α′-linked 2-deoxy trehalose analogues via AuCl3-catalyzed dehydrative glycosylation using hemiacetal glycosyl donors acceptors is described. The relies on the chemoselective Brønsted acid-type activation of tribenzylated hemiacetals in presence other less reactive hemiacetals.
Background: The occurrence of accidental nerve damage during surgery and the increasing application image guidance head-and-neck have highlighted need for molecular targeted nerve-sparing interventions. implementation such interventions relies on availability nerve-specific tracers. In this paper, we describe development a truncated peptide that has an optimized affinity protein zero (P0), most abundant in myelin. Methods Materials: Further C- N-terminal truncation was performed lead...
There was an immediate ad-hoc response of the international scientific community to help scholars from universities affected by Russia's war in Ukraine. Official government-backed funding programmes later allowed offers be sustainable and stable. The #ScienceForUkraine initiative is a grass-root that emerged out desire help; initially created as central database for worldwide help. Its 133 active volunteers engaged with policy-makers bodies improve support Ukrainian academic community.The...
Liver cancer is a leading cause of deaths worldwide. Surgical resection superficial hepatic lesions increasingly guided by the disrupted bile excretion fluorescent dye indocyanine green (ICG). To extend this approach to deeper lesions, dedicated bimodal tracer that facilitates both fluorescence guidance and radioguidance was developed.
Surgically induced nerve damage is a common but debilitating side effect. By developing tracers that specifically target the most abundant protein in peripheral myelin, namely myelin zero (P0), we intend to support fluorescence-guided nerve-sparing surgery. To end, aimed develop dimeric tracer shows superior affinity for P0.Following truncation of homotypic P0 protein-based peptide sequences and fluorescence labeling, lead compound Cy5-P0101-125 was selected. Using bifunctional fluorescent...