A5015768691- Mast cells and histamine
- Adenosine and Purinergic Signaling
- Chemical Synthesis and Analysis
- RNA Interference and Gene Delivery
- Phenothiazines and Benzothiazines Synthesis and Activities
- Autophagy in Disease and Therapy
- PI3K/AKT/mTOR signaling in cancer
- Receptor Mechanisms and Signaling
- Polyamine Metabolism and Applications
University of the Basque Country
2004-2011
Salahaddin University-Erbil
2006
Previously we found that terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. In this report, focusing our attention on the apoptotic mechanisms activated by show drug can potentially activate distinct intrinsic signaling pathways depending culture conditions. Serum-deprived conditions enhance cytotoxic effect terfenadine and caspase-4 -2 are upstream caspase-9. Moreover, although increase ROS levels,...
Previously, we found that the H1 histamine receptor antagonist diphenhydramine induces apoptosis in human acute T-lymphocytic leukemia cells. Since has been shown to act as a growth factor malignant melanoma cells, decided evaluate vitro effect of and other antagonists, such terfenadine, astemizol triprolidine on four cell lines. These antagonists were induce apoptotic death all Apoptosis was determined by assessment phosphatidylserine exposure surface cells nuclear fragmentation....
In our previous works, we have demonstrated that terfenadine (TEF) induces DNA damage and apoptosis in human melanoma cell lines. this present work, studied the effect of histamine on viability A375 cells cell-signalling pathways through which TEF may induce its apoptotic effect. We found exogenous stimulates proliferation a dose- time-dependent manner. Moreover, TEF-induced seems to occur via other cellular independent histamine-signalling system since co-treatment with did not protect from...
Recently, it has been demonstrated that histamine plays an important role in the proliferation of normal and malignant cells. We have examined effects histamine, diphenhydramine, cimetidine (H1 H2 receptor antagonists, respectively) on vitro two human T-cell acute lymphoblastic leukemia cell lines, namely CCRF-CEM Jurkat. Exogenous did not alter or viability these In contrast, diphenhydramine induced apoptosis a dose- time-dependent manner both whereas failed to induce significant at similar...