A5046914289- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Virus-based gene therapy research
- Respiratory viral infections research
- CRISPR and Genetic Engineering
- CAR-T cell therapy research
- Viral Infections and Immunology Research
- Immunotherapy and Immune Responses
- Influenza Virus Research Studies
- Natural product bioactivities and synthesis
- Synthesis and Characterization of Heterocyclic Compounds
- Pharmacological Effects of Natural Compounds
- Peptidase Inhibition and Analysis
- Bacteriophages and microbial interactions
- Nanowire Synthesis and Applications
- Monoclonal and Polyclonal Antibodies Research
- DNA and Nucleic Acid Chemistry
- Plant biochemistry and biosynthesis
- Ubiquitin and proteasome pathways
- T-cell and B-cell Immunology
- RNA and protein synthesis mechanisms
- Sesquiterpenes and Asteraceae Studies
- Toxin Mechanisms and Immunotoxins
- Protein Degradation and Inhibitors
- Immune Cell Function and Interaction
Peking University
2020-2023
Influenza hemagglutinin that drives viral entry into cells via the membrane fusion process is an up-and-coming antiviral drug target. Herein, we described for first time design, synthesis, and biological characteristics of a new class pentacyclic triterpenoid-based proteolysis targeting chimeras (PROTACs) to enhance degradation Among these PROTACs, V3 showed best effect on with median concentration 1.44 μM in ubiquitin proteasome-dependent manner broad-spectrum anti-influenza A virus...
There is an urgent need to develop antiviral drugs and alleviate the current COVID-19 pandemic. Herein we report design construction of chimeric oligonucleotides comprising a 2'-OMe-modified antisense oligonucleotide 5'-phosphorylated 2'-5' poly(A)4 (4A2-5 ) degrade envelope spike RNAs SARS-CoV-2. The was used for searching recognizing target viral RNA sequence, conjugated 4A2-5 guided RNase L activation sequence-specifically RNAs. Since can potently cleave single-stranded during innate...
Betulinic acid (BA) and oleanolic (OA) are plant-derived conjugates found in various medicinal plants that have emerged as potential antitumor agents. Herein, a series of novel BA OA derivatives were synthesized by conjugation with per-O-methylated-β-cyclodextrin (PM-β-CD), their anticancer properties against panel three human cancer cell lines evaluated. Two OA-PM-β-CD (48 50) observed to be the most potent (MCF-7, BGC-823, HL-60), 15- 20-fold decrease IC50 values (IC50: 6.06–8.47 μM)...
Rapid diagnosis and vaccine development are critical to prevent the threat posed by viruses. However, rapid tests, such as colloidal gold assays, yield false-negative results due low quantities of viruses; moreover, conventional virus purification, including ultracentrifugation nanofiltration, is multistep time-consuming, which limits laboratory research commercial viral vaccines. A enrichment purification technique will improve clinical sensitivity simplify production. Hence, we developed...
Abstract There is an urgent need to develop antiviral drugs and alleviate the current COVID‐19 pandemic. Herein we report design construction of chimeric oligonucleotides comprising a 2′‐OMe‐modified antisense oligonucleotide 5′‐phosphorylated 2′‐5′ poly(A) 4 (4A 2‐5 ) degrade envelope spike RNAs SARS‐CoV‐2. The was used for searching recognizing target viral RNA sequence, conjugated 4A guided RNase L activation sequence‐specifically RNAs. Since can potently cleave single‐stranded during...
Abstract There is an urgent need for effective antiviral drugs to alleviate the current COVID-19 pandemic. Here, we rationally designed and developed chimeric antisense oligonucleotides degrade envelope spike RNAs of SARS-CoV-2. Each oligonucleotide comprises a 3’ sequence target recognition 5’-phosphorylated 2’-5’ poly(A)4 guided ribonuclease L (RNase L) activation. Since RNase can potently cleave single strand RNA during innate response, improved degradation efficiency was twice as much...
SARS-Cov-2 In der Zuschrift aus S. 21830 berichten Xinjing Tang et al. über die effiziente Hemmung von SARS-CoV-2 mit chimären Antisense-Oligonukleotiden durch Aktivierung RNase L.