Abstract Background Antibiotic resistance has necessitated fluoroquinolone use but little is known about the selective forces and trajectory in malaria-endemic settings, where selection from antimalarial chloroquine for fluoroquinolone-resistant bacteria been proposed. Methods Antimicrobial was studied fecal Escherichia coli isolates a Nigerian community. Quinolone-resistance determining regions of gyrA parC were sequenced nalidixic acid resistant strains horizontally-transmitted...

Diarrhoeagenic Escherichia coli (DEC) pathotypes are among the most common bacterial causes of morbidity and mortality in young children. These pathogens not sought routinely capacity for their detection is limited Africa. We investigated distribution dissemination DEC 126 children paired with mothers a Nigerian community. A total 861 E. were isolated from diarrhoea mothers. Antimicrobial susceptibility each isolate was determined by Kirby-Bauer disc diffusion technique. All isolates...

Antimicrobial resistance among enteric bacteria in Africa is increasingly mediated by integrons on horizontally acquired genetic elements. There have been recent reports of such elements invasive pathogens across Africa, but very little known about the faecal reservoir integron-borne genes.We screened 1098 Escherichia coli isolates from 134 mother-child pairs for integron cassettes PCR using primers that anneal to 5' and 3' conserved ends cassette regions plasmid replicons. Genetic...

Helicobacter pylori has become recognized as a major cause of gastroduodenal diseases in man. Evidence indicates that once acquired, H. persists, usually for life unless eradicated by antimicrobial therapy. Over the past few years, we have accumulated some knowledge epidemiology Ile-Ife, South-West Nigeria. In one collaborative study, detected 195 (73%) patients referred endoscopy at Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC). Furthermore observed variegated gastric...

Abstract This study assessed the bacteriological quality of raw, treated, and distributed water from Ede-Erinle Opa reservoirs in Osun State, Nigeria. was to determine potability these waterwork stations. Eighteen sampling points were established across two reservoir networks for this study. Samples collected bi-monthly annual cycles. Serial dilution pour plate methods employed enumeration bacterial load. Total heterotrophic bacteria count (THBC) total coliform (TCBC) enumerated on nutrient...

Abstract Background Diarrhoeagenic Escherichia coli (DEC) strains are common causes of morbidity and mortality worldwide. Waterborne DEC could pose a health risk to humans through domestic use contaminated water. However, epidemiological studies on in well water scarce Nigeria. This study determined the prevalence, diversity factors associated with presence Ile-Ife, southwestern Methods We assessed 143 wells for safety questionnaire was administered. Contaminating isolates were identified as...

Pseudomonads constitute critical agents of opportunistic infections in hospital settings particularly immunocompromised patients and Pseudomonas aeruginosa is a major flagship member these infectious agents. This study assessed the distribution spp. associated with their antibiotic resistance patterns as part an stewardship intervention program surveillance.One hundred fifty from different clinical specimens were obtained Obafemi Awolowo University Teaching Hospitals Complex Ile-Ife. Culture...

Background: Gastrointestinal infection is one of the most common infections among HIV patients. Candida spp have been implicated in aetiology chronic diarrhoea patients, but little known about this Nigeria.Objectives: We determined prevalence faecal candidiasis patients relation to diarrhoea, CD4 counts, and other socio-demographic factors spectrum isolates involved.Methods: One hundred fifty four were investigated. species identified by standard techniques. Socio-demographic clinical...

Abstract Antimicrobial resistance is rapidly expanding, in a large part due to mobile genetic elements. We screened 94 fecal fluoroquinolone-resistant Escherichia coli isolates from Nigeria for six plasmid-mediated quinolone (PMQR) genes. Sixteen harbored at least one of the PMQR genes and four were positive aac-6-Ib-cr . In strain, was mapped 125 Kb self-transmissible IncFII plasmid, pMB2, which also bears bla CTX-M-15 , seven other functional multiple pseudogenes. Laboratory strains...

To investigate the prevalence and associates of asymptomatic bacteriuria (ASB) in a sample Nigerian diabetic patients.Cross-sectional descriptive analytic study.The Wesley Guild Hospital Ife State Hospital, both units Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria.One hundred thirty five patients 57 non-diabetic as controls.Demographic parameters participants were recorded. Significant was determined for each mid-stream urine specimen obtained from all subjects....

We report on an 8-year-old patient with septicaemia unresponsive to therapy for five weeks. Undetected, extended-spectrum β-lactamase (ESBL) production by the infecting Klebsiella strain was regarded as responsible treatment failure. Intravenously administered imipenem during sixth week led sustained resolution of fever. Resource-limited hospitals can incur prohibitive costs from ESBL-producer infections because diagnostic limitations and consequent failure involving prolonged supportive therapy.

Active screening of blood donors has practically eliminated viral pathogens during provision transfusion services; however, transfusion-associated bacterial sepsis remains an important health-care concern. Currently, it is the most frequently reported cause infectious transfusion-related fatalities. The aim this study was to determine prevalence contamination in donor and/or products, and also identify isolated microorganism a semi-urban university teaching hospital setting Nigeria. The...

Screening donors has practically eliminated viral pathogens in blood for transfusion; however, transfusion-associated bacterial sepsis remains an important health-care concern.Currently, it is the most frequently reported cause of transfusion-related fatality from infection.The aim this study was to determine prevalence and type contamination donor and/or products, a semi-urban university teaching hospital Nigeria.The carried out at Obafemi Awolowo University Teaching Hospitals Complex,...

Background: The emergence and spread of antibiotic resistant bacteria has become a serious problem worldwide. House­flies are potential carriers pathogenic could be contributing to the global these strains in environments.We investigated prevalence antimicrobial profiles isolated from houseflies Akure. Methods: Twenty-five were captured by sterile nylon net slaughterhouse, garbage dump, human house, hospital, eatery 9:00am 1:00pm when flies active transported immediately la­bor­atory...

the continuous generation of wastewater and its release into environment with little or no treatment remains a threat to public health. We examined prevalence antibiotic susceptibility profiles Vibrio species isolated from untreated samples Ondo State Specialist Hospital Okitipupa, Nigeria, as part global efforts provide information for containing spread resistant infections.twelve hospital were collected aseptically transported laboratory analysis. The processed on thiosulphate citrate bile...

We sought to determine the prevalence of asymptomatic bacteriuria (ASB) in patients with sickle cell disease (SCD), susceptibility profile its agents and their extended-spectrum β-lactamase (ESBL) production.

Panton-Valentine Leucocidin (PVL)-producing Staphylococcus aureus strains have been implicated in serious community-associated invasive infections and their increasing multidrug resistance is a major global health concern. Thus, we investigated the prevalence of PVL gene antimicrobial profile nasal S. isolates from healthy adults Tundu-Wada, Gombe State Nigeria.A total 262 samples were obtained cultured. The identified as by standard morphological biochemical methods alongside with...

This study determined the prevalence of Methicillin-resistant Staphylococcus aureus (MRSA) from 246 clinical samples collected at a tertiary care hospital, its antimicrobial susceptibility, spectrum infections and associated risk factors.Standard procedures were used for isolation, screening, susceptibility testing.The result showed that 41 (40.2%) out 102 S. isolated methicillin-resistant while 61 (59.8%) methicillin-sensitive.The rate MRSA male female group was 37.3% 43.1%...

Background: Hypertension is a major health problem in sub-Sahara Africa. Several studies have suggested role of asymptomatic bacteriuria (ASB) the aetiology hypertension, but there dearth information on this association Africa where burden hypertension high. We investigated prevalence bacteriuria, its with and determined antibiotic resistance patterns implicated bacterial isolates an urban community Ile-Ife.Methods: One hundred seventy-four apparently healthy individuals were for ASB....

The aqueous and ethanolic extracts of Moringa oleifera leaf were evaluated for safety, antimalarial antipyretic activities because it is commonly used various types ailments especially malaria fever. concentration these (0-800mg/kg) tested against Plasmodium berghei infected albino mice either sex, in a Peters’ four day antiplasmodial test while malaria- induced mice. Their possible effects on haematological parameters PCV, WBC, neutrophil, lymphocytes count liver enzymes also determined as...