A5033619090- Microtubule and mitosis dynamics
- Cellular transport and secretion
- Cellular Mechanics and Interactions
- Genetics and Neurodevelopmental Disorders
- Enzyme function and inhibition
- Synthesis and Reactions of Organic Compounds
- Cancer, Hypoxia, and Metabolism
- Neurogenesis and neuroplasticity mechanisms
- PI3K/AKT/mTOR signaling in cancer
- Sarcoma Diagnosis and Treatment
- Computational Drug Discovery Methods
- Cancer Genomics and Diagnostics
- Glioma Diagnosis and Treatment
- Chemistry and Chemical Engineering
Istanbul University
2024
Koç University
2020-2023
Bahçeşehir University
2017-2021
ABSTRACT Cell division requires dramatic reorganization of the cell cortex, which is primarily driven by actomyosin network. We previously reported that protocadherin 7 (PCDH7) gets enriched at surface during mitosis, required to build up full mitotic rounding pressure. Here, we report PCDH7 interacts with and palmitoylated palmitoyltransferase, ZDHHC5. ZDHHC5 colocalize translocate cleavage furrow cytokinesis. The localization depends on palmitoylation activity Silencing increases...
Subcortical heterotopia is a cortical malformation associated with epilepsy, intellectual disability, and an excessive number of neurons in the white matter. Echinoderm microtubule-associated protein like 1 (EML1) mutations lead to subcortical heterotopia, abnormal radial glia positioning wall, prior onset. This perturbed distribution proliferative cells likely be critical event for formation; however, underlying mechanisms remain unexplained. study aimed decipher early cellular alterations...
Cell cycle inhibitors are considered as hallmark strategy for cancer treatment due to their relatively higher selectivity and efficacy on various types in comparison cytotoxic agents. Small molecules target dividing cells G1/S, G2 or M phases of arrest eventually trigger enter apoptosis and/or inhibit tumor growth. at G2/M phase is a widely used approach proliferating cells. We report novel angiotensin II receptor type I (AT1R) antagonist that also targets CDC2 (CDK1) kinase thereby showing...
ABSTRACT Cell division requires dramatic reorganization of the cell cortex that is primarily driven by actomyosin network. We previously reported Protocadherin 7 (PCDH7) enriches at surface during mitosis which required for building up full mitotic rounding pressure. Here we showed PCDH7 gets palmitoylated and interacts with palmitoyltransferase, ZDHHC5. Both ZDHHC5 co-localize surface, they translocate to cleavage furrow cytokinesis. PCDH7’s localization depends on palmitoylation activity...