A5089745488- Logic, programming, and type systems
- Formal Methods in Verification
- Model-Driven Software Engineering Techniques
- Caching and Content Delivery
- Parallel Computing and Optimization Techniques
- Peer-to-Peer Network Technologies
- Mobile Ad Hoc Networks
- Software Testing and Debugging Techniques
- Semantic Web and Ontologies
- Opportunistic and Delay-Tolerant Networks
- Distributed systems and fault tolerance
- Logic, Reasoning, and Knowledge
- Distributed and Parallel Computing Systems
- Bioactive Compounds and Antitumor Agents
- Constraint Satisfaction and Optimization
- Simulation Techniques and Applications
- Invertebrate Immune Response Mechanisms
- Modeling and Simulation Systems
- Advanced Data Storage Technologies
- Natural Language Processing Techniques
- Energy Efficient Wireless Sensor Networks
- DNA and Biological Computing
- Embedded Systems Design Techniques
- Cooperative Communication and Network Coding
- Aquaculture disease management and microbiota
Waseda University
2015-2024
Tohoku University
2001-2024
Institute of Aging
2024
Egypt-Japan University of Science and Technology
2022-2024
Tohoku University of Community Service and Science
2023
Kochi University of Technology
2011-2022
Tokyo Yamate Medical Center
2021-2022
Kwansei Gakuin University
2020
Shimane Prefectural Central Hospital
2019
Hitachi Global Storage Technologies (United States)
2017
We review the design of concurrent logic language GHC, basis kernel for Parallel Inference Machine being developed in Japanese Fifth Generation Computer Systems project, and parallel KL1, actual implemented used. The key idea these languages is separation concurrency parallelism. Clarification concepts this kind seems to play an important role bridging gap between inference systems knowledge information processing a coherent manner. In particular, new has always encouraged us re-examine...
Innate immunity is the front line of self-defense against microbial infection. After searching for natural substances that regulate innate using an ex vivo Drosophila culture system, we identified a novel dimeric chromanone, gonytolide A, as immune promoter from fungus Gonytrichum sp. along with gonytolides B and C. Gonytolide A also increased TNF-α-stimulated production IL-8 in human umbilical vein endothelial cells.
Two new protein phosphatase inhibitors, oscillamide B (1) and C (2), were isolated from the cyanobacteria Planktothrix (Oscillatoria) agardhii P. rubescens. The structures of inhibitors elucidated by analysis HRFABMS, 1D 2D NMR spectra, chemical degradation. These are ureido-containing cyclic peptides inhibited serine/threonine phosphatases PP1 PP2A. inhibitory activities closely related to Arg N-Me-Hty residues in peptides.
Selective inhibitors of protein tyrosine phosphatases (PTPs) and dual-specificity (DSPs) are expected to be useful tools for clarifying the biological functions PTPs themselves also candidates novel therapeutics. We planned a library approach identification PTP/DSP in which 3-acyltetronic acid is used as "core" phosphate mimic. A series tetronic derivatives were synthesized evaluated VHR cdc25B. Several compounds found potent cdc25B, key enzyme cell-cycle progression. The promising results...
Ensuring reliable data transmission in all Vehicular Ad-hoc Network (VANET) segments is paramount modern vehicular communications. operations face unpredictable network conditions which affect routing protocol adaptiveness. Several solutions have addressed those challenges, but each has noted shortcomings. This work proposes a centralised-controller multi-agent (CCMA) algorithm based on Software-Defined Networking (SDN) and Delay-Tolerant (DTN) principles, to enhance VANET performance using...
Six new polyketides, bitungolides A−F (1−6), have been isolated from the Indonesian sponge Theonella cf. swinhoei and their structures elucidated by spectroscopic data X-ray diffraction analysis. The are a class of metabolites that inhibit dual-specificity phosphatase VHR.
A potent inhibitor of a dual‐specificity protein phosphatase, VHR (vaccinia H1 related), was isolated during screening microbial metabolites. This identified as 4‐isoavenaciolide (4‐iA), and determined to irreversibly inhibit phosphatase activity with 50% inhibitory concentration 1.2 μM. Detailed tandem mass spectrometry analyses proteolysed fragments revealed that two molecules 4‐iA bound molecule at the different fragments: one containing catalytic domain other α6 helix positioned surface...
After searching for natural substances that regulate innate immunity using the ex vivo Drosophila culture system, a benzoyl pyrrole-type compound, celastramycin A, was identified and isolated as potent suppressor. By synthesizing previously reported structure 1 another compound 2 in Japanese patent, correct of A confirmed to be 2. Compound suppressed production IL-8 (IC50 0.06 μg/mL) human umbilical vein endothelial cells (HUVECs).
Bis(arylmethylidene)acetone derivatives are an important class of curcumin analogues that exhibit various biological and pharmacological activities. We herein report GO-Y086, a biotinylated bis(arylmethylidene)acetone, inhibits cancer cell growth. also show GO-Y086 specifically interacts with the nuclear protein KSRP/FUBP2 by covalent modification. markedly suppresses expression c-Myc protein, which plays role in cellular proliferation whose is regulated KSRP/FUBP2.
Bacillus cereus is a gram-positive rod bacterium that responsible for food poisoning. It naturally widely distributed, and thus often contaminates cultures. Although it rarely considered responsible, can cause serious infections under certain conditions. However, lethal infections, especially in immunocompetent patients, are rare. A healthy 60-year-old man developed community-acquired B. pneumonia alveolar hemorrhage unveiled by abrupt chest pain hemoptysis with no other advance symptoms....