In this century, the development of nanotechnology is projected to be establishment a technological evolutionary modern era. Recently, one most active subjects substantial research in material sciences and hence metal nanoparticles have great scientific interest because their unique optoelectronic physicochemical properties with applications diverse areas such as electronics, catalysis, drug delivery, or sensing. Nanotechnology provides an understanding on fundamental objects at atomic,...

Plants have been the primary source of medicines since life on earth; more than 50 % existing cancer treatments are derived from plants.An ethnopharmacological survey herbal remedies used in treatment was carried out West Bank/ Palestine. A questionnaire distributed to one hundred and fifty herbalists, traditional healers rural dwellers. Collected information included names plants, parts, types cancers for which these plants were also their methods preparation. To identify most important...

Background This study aimed to evaluate the efficacy of ChatGPT, an advanced natural language processing model, in adapting and synthesizing clinical guidelines for diabetic ketoacidosis (DKA) by comparing contrasting different guideline sources. Methodology We employed a comprehensive comparison approach examined three reputable sources: Diabetes Canada Clinical Practice Guidelines Expert Committee (2018), Emergency Management Hyperglycaemia Primary Care, Joint British Societies (JBDS) 02...

Abstract Background Many modern pharmaceutical researchers continue to focus on the discovery and evaluation of natural compounds for possible therapies obesity, diabetes, infections, cancer, oxidative stress. Extraction Ocimum basilicum seed essential oil its antioxidant, anti-obesity, antidiabetic, antibacterial, cytotoxic activities were goals current study. Method O . was extracted evaluated anticancer, antimicrobial, anti-diabetic properties utilizing standard biomedical assays. Results...

The advances in knowledge about production and stability of dispersed systems enable the development differentiated vehicles such as nanoemulsions nanoemulgels, which have been effectively used to increase bioavailability improve active ingredients.Nowadays there is an intensely usage natural bioactive materials medicinal agent pharmaceutical industries.Swietenia macrophylla oil due bioactivity different parts plant anti-inflammatory, anti-mutagenicity, anti-tumor.SM Nanoemulgels were...

Cancer now is one of the leading causes mortality in world. There has been a lot effort to discover new anticarcinogenic agents that allow treatment with fewer side effects. A series isoxazole-carboxamide derivatives (2a–2g) were synthesised and evaluated for their cytotoxic activity against breast (MCF-7), cervical (HeLa), liver (Hep3B) cancer cell lines antioxidant 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. The results showed 2d 2e most active compounds Hep3B cells, half-maximal...

In addition to their wide therapeutic application, benzoates and benzoic acid derivatives are the most commonly utilized food preservatives. The purpose of this study was estimate antioxidant, anti-diabetic, anti-obesity activities four 2-(phenylthio)-ethyl benzoate utilizing standard biomedical assays. results revealed that 2a compound has potent antidiabetic activity through inhibition α-amylase α-glycosidase with IC50 doses 3.57 ± 1.08 10.09 0.70 µg/ml, respectively, compared positive...

Cancer is one of the most dangerous and widespread diseases in world today it has risen to position leading cause death around globe last few decades. Due inherent resistance many types cancer conventional radiotherapy chemotherapy, vital develop innovative anticancer medications. Recently, a strategy based on nanotechnology been used improve effectiveness both old new drugs.The present study aimed design synthesize series phenyl-isoxazole-Carboxamide derivatives, evaluate their properties,...

When inserting screws into a vertebral pedicle, the surgeon usually exposes back part of vertebra and uses his or her anatomic knowledge to align drill in proper direction. A slight error direction may result an important position tip screw. This is done with no direct visibility crucial structures (spinal cord, pleura, vessels). Statistical analysis series surgical procedures has shown that 10% 40% are not installed correctly. To reduce risk complication, computer assisted method proposed...

The variability in width, height, and spatial orientation of a spinal pedicle makes screw insertion delicate operation. aim the current paper is to describe computer-assisted surgical navigation system based on fluoroscopic X-ray image calibration three-dimensional optical localizers order reduce radiation exposure while increasing accuracy reliability procedure for insertion. Instrumentation using transpedicular fixation was performed: first group, conventional carried out with 26 patients...

This study is aimed at developing coriander oil into a nanoemulgel and evaluating its antimicrobial anticancer effects. Coriander (Coriandrum sativum) was developed by using self-nanoemulsifying technique with Tween 80 Span 80. Hydrogel material (Carbopol 940) then incorporated the nanoemulsion mixed well. After this, we evaluated particle size, polydispersity index (PDI), rheology, effect, cytotoxic activity. The had PDI of 0.188 size 165.72 nm. Interesting results were obtained against...

Miconazole is a synthetic derivative of imidazole, medication with broad-spectrum antifungal agent that used to treat localized vaginal, skin, and nail infections. The aim the study was develop an innovative technique improve permeability efficacy topical miconazole nitrate. A nanoemulgel nitrate formulated by incorporation nanoemulsion hydrogel. first optimized using self-emulsifying technique, drug then loaded into optimum formulation evaluated prior mixing formulations were for their...

Since ancient times, plants with medicinal properties have played a crucial role in the prevention and treatment of various diseases. The current study focuses on formulation assessment Vitis vinifera (V. vinifera) oil nanoemulgel, exploring its potential antimicrobial, anticancer, anti-inflammatory properties. incorporation into nanoemulsion was achieved through self-nanoemulsifying technique, utilizing Tween 80 Span as emulsifying agents. addition Carbopol hydrogel to resulted formation...

The use of herbal products by pregnant and lactating mothers without awareness their harmful effects may expose both mother fetus or infant to great dangers, such as abortion, premature delivery, uterine bleeding, physical mental retardation the fetus. Thus, aim this study was investigate extent which product treatment is used reason for are ensure that these reasons correct. An ethnopharmacological survey (cross-sectional observational design study) using a pre-piloted questionnaire...

Abstract a series of benzodioxole compounds were synthesized and evaluated for their cytotoxic activity against cervical (Hela), colorectal (Caco-2), liver (Hep3B) cancer cell lines. Compounds 5a, 5b, 6a, 6b, 7a 7b showed very weak or negligible anticancer with IC 50 3.94-9.12 mM. On the contrary, carboxamide containing 2a 2b activity. Both reduced Hep3B secretions α-fetoprotein (α-FP) to 1625.8 ng/ml 2340 ng/ml, respectively, compared 2519.17 in untreated cells. The results also that...

Abstract Currently, available therapies for diabetes could not achieve normal sugar values in a high percentage of treated patients. In this research project, series 17 benzodioxole derivatives were evaluated as antidiabetic agents; that belong to three different groups against lipase and alpha-amylase (α-amylase) enzymes. The results showed 14 compounds have potent inhibitory activities α-amylase with IC 50 below 10 µg/ml. Among these compounds, 4f was the most compound an value 1.11 µg/ml...