A5062251582- Chemical synthesis and alkaloids
- Cholinesterase and Neurodegenerative Diseases
- Natural Antidiabetic Agents Studies
- Alkaloids: synthesis and pharmacology
- Phytochemicals and Antioxidant Activities
- Medicinal Plants and Neuroprotection
- Medicinal Plants and Bioactive Compounds
- Ethnobotanical and Medicinal Plants Studies
- Dialysis and Renal Disease Management
- Herbal Medicine Research Studies
- Neonatal Respiratory Health Research
- Essential Oils and Antimicrobial Activity
- Renal function and acid-base balance
- Respiratory Support and Mechanisms
- Psychedelics and Drug Studies
- African Botany and Ecology Studies
- Pharmacological Effects of Natural Compounds
- Phytochemistry and Bioactivity Studies
- Papaya Research and Applications
- Vascular Procedures and Complications
- Ginger and Zingiberaceae research
- Mangiferin and Mango Extracts
- RNA and protein synthesis mechanisms
- Fatty Acid Research and Health
- Acute Kidney Injury Research
Bangladesh Council of Scientific and Industrial Research
2024
Khulna University
2024
Rajshahi Medical College
2024
Charles University
2020-2023
Primeasia University
2023
Dhaka Shishu Hospital
2023
University of Hradec Králové
2023
Mawlana Bhashani Science and Technology University
2017-2021
Bangabandhu Sheikh Mujib Medical University
2019-2020
National Institute of Cardiovascular Diseases
2017-2020
Neurodegenerative diseases are incurable and debilitating conditions that result in the progressive degeneration of nerve cells, which affect cognitive activity. Currently, as a multiple studies linking Alzheimer's disease (AD) to oxidative damage, uses natural antioxidant prevent, delay, or enhance pathological changes underlying progression AD has received considerable attention. Therefore, this study was aimed at examining effect ethanolic extracts Phyllanthus emblica (EEPE) ripe (EEPEr)...
Nature is the best source of complementary and alternative medicine. The plant Phyllanthus acidus (PA) L. has been used traditionally in pain, inflammatory oxidative stress related disorders. In this consequence, methanolic extract PA (MEPA) was selected to explore ability enhance cognitive function, brain antioxidant enzymes anti-acetylcholinesterase activity which can be for treatment disorders like Alzheimer's disease (AD). purpose study investigate neuroprotective effect MEPA on learning...
Thirteen known (1–12 and 16) three previously undescribed Amaryllidaceae alkaloids of belladine structural type, named carltonine A-C (13–15), were isolated from bulbs Narcissus pseudonarcissus cv. Carlton (Amaryllidaceae) by standard chromatographic methods. Compounds in sufficient amounts, not tested previously, evaluated for their vitro acetylcholinesterase (AChE; E.C. 3.1.1.7), butyrylcholinesterase (BuChE; 3.1.1.8) prolyl oligopeptidase (POP; 3.4.21.26) inhibition activities....
Background: “Dimocarpus longan Lour” is a tropical and subtropical evergreen tree species mainly found in China, India, Thailand; this plant, naturally Bangladesh, even locally, used as “kaviraj” medication for treating different diseases, such gastrointestinal disorders, wounds, fever, snake bites, menstrual problem, chickenpox, bone fractures, neurological reproductive health. Different parts of especially juice pulp, pericarp, seeds, leaves, flowers, contain diverse group botanical...
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A total of 20 derivatives (1–20) the crinane-type alkaloid ambelline were synthesized. These semisynthetic assessed for their potency to inhibit both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). To predict central nervous system (CNS) availability, logBB was calculated, data correlated well with those obtained from parallel artificial membrane permeability assay (PAMPA). All compounds should be able permeate blood–brain barrier (BBB) according results. 7 aromatic (5, 6, 7,...
Oxidative stress is intensely linked with neurodegenerative disorders, especially Alzheimer's disease (AD). Searching for medicinal plant the nootropic activity controling development and progression of AD has received extensive consideration. The Phyllanthus reticulatus (PR) Poir. known in Bengali as Panjuli belongs to family Euphorbiaceae. Previous studies have shown antioxidant, analgesic, anti-inflammatory, etc. activities this plant. Therefore, objective study was examine effect...
To lead a normal life, oxidation is essential owing to carry out physiological and biochemical functions that the generation of reactive oxygen species (ROS) plus nitrogen (RNS)[1]. ROS RNS such as hydrogen peroxide radicals, hydroxyl nitric oxide radical, peroxyl superoxide radicals singlet are highly molecules can damage biomolecules including carbohydrates, lipids, proteins, nucleic acids (DNA RNA) alter their functions[2-7]. They act in cell processes, at low moderate concentrations, but...
Nidrakar Bati (NKB) is an herbal remedy consisted with seven medicinal herbs widely used to cure Somnifacient (sleeping aid) in South Asia as Ayurvedic system. In the present study, pharmacological and toxicological effects of this medicine was investigated mice validate safety efficacy herb.Organic solvent extracts NKB were prepared using maceration method. Effect on central nervous system evaluated hypnotic activity assay. metabolic activity, assessing involvement thyroid conducted hypoxia...
Different species, hybrids and varieties of the genus Hippeastrum (Amaryllidaceae) are planted for ornamental purposes at same time they represent a rich source interesting secondary metabolites called Amaryllidaceae alkaloids.These compounds display wide spectrum biological activities.In current study, six taxa were evaluated their alkaloid profile by GC-MS.Using preparative TLC, five alkaloids isolated in pure form, three them cytotoxic antiproliferative potencies on panel human cancer...
Two new minor Amaryllidaceae alkaloids were isolated from Hippeastrum × hybridum cv. Ferrari and Narcissus pseudonarcissus Carlton. The chemical structures identified by various spectroscopic (one- two-dimensional (1D 2D) NMR, circular dichroism (CD), high-resolution mass spectrometry (HRMS) comparison with literature data of similar compounds. Both screened for their human acetylcholinesterase (hAChE) butyrylcholinesterase (hBuChE) inhibition activity. One the compounds, a heterodimer...
Alzheimer's disease (AD) is a multifactorial neurodegenerative condition of the central nervous system (CNS) that currently treated by cholinesterase inhibitors and N-methyl-d-aspartate receptor antagonist, memantine. Emerging evidence strongly supports relevance targeting butyrylcholinesterase (BuChE) in more advanced stages AD. Within this study, we have generated pilot series compounds (1-20) structurally inspired from belladine-type Amaryllidaceae alkaloids, namely carltonine A B,...
cardienolides, steroids, bufadienolides and lipids [12][13][14].In the ethno-pharmacological properties, leaves of this plant have been represented to exhibit anti-ulcer, mitigating moderating, relieving pain, extraordinary adversary histamine anti-allergic activity.Kalanchoe crenata extracts are used in ethnomedicine for treatment earache, burns, abscesses, insect bites, whitlow, diarrhea cithiasis [15].It also diabetes, dissolving kidney stones, respiratory tract infections, as well...
Many traditional medicines in use are obtained from medicinal plants, minerals and organic matter. During the past several years, there has been increasing interest among uses of various plants system medicine for treatment different ailments. Coccinia grandis used as a household remedy diseases. The whole plant having pharmacological activities like analgesic, antipyretic, anti-inflammatory, antimicrobial, antiulcer, antidiabetic, antioxidant, hypoglycemic, hepatoprotective, antimalarial,...
Hyponatremia is a very common electrolyte imbalance in admitted diabetic patients which leads to substantial morbidity and mortality. There no existing record for profiling of hyponatremia Bangladeshi subjects. The objective this study was find out the factors influencing associated co-morbidities tertiary care hospital. Samples were selected from all adult nonpregnant with serum sodium level < 135 mmol/L irrespective their cause admission. A total number 115 studied. Informations...
Background: In resource-constrained healthcare settings, neonatal surgical challenges contribute significantly to elevated morbidity and mortality rates, particularly in low- middle-income countries. This study aimed comprehensively investigate the demographic distribution, prevalence of conditions, procedural trends, temporal patterns, postoperative complications neonates admitted a government hospital Bangladesh Methods: A retrospective observational was conducted, analyzing data from...