A5054064535- RNA modifications and cancer
- Genomics and Chromatin Dynamics
- Microtubule and mitosis dynamics
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- Ubiquitin and proteasome pathways
- Chromosomal and Genetic Variations
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- interferon and immune responses
- Telomeres, Telomerase, and Senescence
- Advanced biosensing and bioanalysis techniques
National University of Singapore
2017-2021
National University Cancer Institute, Singapore
2017-2021
TIP60 is a lysine acetyltransferase and known to be haplo-insufficient tumor suppressor. downregulation an early event in tumorigenesis which has been observed several cancer types including breast colorectal cancers. However, the mechanism by it regulates progression not well understood. In this study, we identified role of silencing endogenous retroviral elements (ERVs). TIP60-mediated ERVs dependent on BRD4. BRD4 positively regulate expression enzymes, SUV39H1 SETDB1 thereby, global H3K9...
HIV1-TAT interactive protein (TIP60) is a haploinsufficient tumor suppressor. However, the potential mechanisms endowing its suppressor ability remain incompletely understood. It plays vital role in virus-induced cancers where TIP60 down-regulates expression of human papillomavirus (HPV) oncoprotein E6 which turn destabilizes TIP60. This intrigued us to identify TIP60, context viral infection, it targeted by oncoproteins. Through an array molecular biology techniques such as Chromatin...
Abstract Thyroid hormone receptor interactor 12 (TRIP12) is an E3 ligase most notably involved in the proteolytic degradation of tumor suppressor p14ARF. Through this process, it proposed that TRIP12 plays oncogenic role initiation and growth. However, its other cancer processes unknown. In study, using publicly available patient datasets, we found to be associated with distant metastasis-free survival breast cancer, suggesting inhibitory metastasis. Following depletion,...
Abstract TIP60, a lysine acetyltransferase and H2AZ, histone H2A variant are involved in transcription DNA repair. Recent studies suggest that H2AZ acetylation is dependent on TIP60. Here, we show TIP60 acetylates both isoforms of vitro cells. Utilizing ChIP-seq RNA-seq to identify the genes regulated by TIP60-dependent find correlates with expression damage repair, amongst several other pathways. In line this, TIP60-depleted cells exhibit increased sensitivity damage-inducing drug...
Abstract Differences in RNA processing, specifically splicing, contribute to enormous diversity that can be generated from the eukaryotic genome. Given increasing evidence show splicing occur co-transcriptionally, chromatin structure and histone modifications have been reported affect choice of a splice site. For instance, HDAC inhibitor treatment has shown alternative splicing. TIP60 is haploinsufficient tumor suppressor gene frequently downregulated cancers. lysine acetyltransferase...
ABSTRACT Thyroid hormone receptor interactor 12 (TRIP12) is an E3 ligase most notably involved in the proteolytic degradation of tumor suppressor p14ARF. Through this process, it proposed that TRIP12 plays oncogenic role initiation and growth. However, its other cancer processes such as metastasis unknown. In study, using publicly available patient datasets, we found to be associated with distant metastasis-free survival breast cancer, suggesting a contrary process inhibitory metastasis....