Pancreatic cancer is one of the most appalling cancers with a pessimistic prognosis. Despite many therapies, there has been no improvement survival rates. In this study, we assessed anti-cancer effects kaempferol, well known flavonoid having functional bio-activity against various malignant tumors. Kaempferol had on Miapaca-2, Panc-1, and SNU-213 human pancreatic cells. dose-dependent manner, kaempferol decreased viability these cells by increasing apoptosis. particular, effectively...

Pancreatic cancer is one of the most dangerous cancers and associated with a grave prognosis. Despite increased knowledge complex signaling networks responsible for progression pancreatic cancer, many challenging therapies have fallen short expectations. In this study, we examined anti-migratory effect quercetin 3-O-glucoside in epidermal growth factor–induced cell migration by inhibiting EGF receptor (EGFR) several human lines. Treatment quercetin, 3-O-glucoside, 7-O-glucoside...

Angiogenesis is essential for tumor growth and a promising target cancer therapy. Blood vessel monitoring an indispensable tool evaluation development of anti-angiogenic drugs. Here, we report new noninvasive in vivo imaging tool, named dynamic fluorescence (DyFI), the simultaneous measurement multiple vascular parameters including density, perfusion rate, permeability using spatiotemporal profiles indocyanine green. Using DyFI xenograft model, quantitatively measured tumors normal tissues...

No effective therapeutics have yet been developed for pancreatic cancer. 2-Methoxy-4-vinyl phenol (2M4VP), a member of the class phenols, has demonstrated to anti-inflammatory properties and cause cell cycle arrest making it an attractive candidate drug treatment cancer.The effects 2M4VP were examined in Panc-1 SNU-213 human cancer cells.2M4VP had anticancer on lines, SNU-213. reduced viability cells by inhibiting expression nuclear antigen (PCNA) protein. also suppressed migratory activity...

Pancreatic cancer exhibits resistance to currently available drugs in the pharmaceutical industry. The development of new is crucial, and research on plant substances with biological activities against actively underway. This study explored potential use fenugreek seed extract (FSE) pancreatic treatment as anticancer activity FSE still poorly understood. cells was evaluated using cell viability apoptosis assays. migration rate quantified wound healing Transwell Western blotting utilized...

Abstract Pancreatic cancer remains one of the most deadly cancers, with a grave prognosis. Despite numerous endeavors to improve treatment neoplasm, limited progress has been made. In present study, we investigated role dual specificity phosphatase 28 (DUSP28) in relation anti-cancer drug sensitivity and migratory activity human pancreatic cells for first time. Analysis using Universal exPress Codes (UPCs) GEO database showed significantly higher DUSP28 mRNA expression cancers. We found that...

Abstract Pancreatic cancer remains one of the most deadly cancers with a grave prognosis. Despite continuous efforts to improve remedial values, limited progress has been made. We have reported that dual specificity phosphatase 28 (DUSP28) critical role chemo-resistance and migration in pancreatic cancers. However, its mechanism unclear. Here, we further clarify function DUSP28 Analysis using public microarray database vitro assay indicated platelet derived growth factor A (PDGF-A)...

The aim of this study was to investigate matrix metalloproteinase 11 (MMP11) as a promising biomarker in human pancreatic cancer.A consecutive eliminating method used select candidates cancer. mRNA and protein expression levels were determined tissues whole blood samples healthy donors cancer patients. prognostic value MMP11 using various data-sets Liptak's Z analysis.Analysis Gene Expression Omnibus (GEO) database showed significantly higher compared that normal tissues. specifically...

The prognosis of pancreatic cancer has not improved despite considerable and continuous effort. Dual-specificity phosphatase 28 (DUSP28) is highly expressed in human cancers exerts critical effects. However, knowledge its function extremely limited. Here, we demonstrate the peculiar role DUSP28 cancers. Analysis using Gene Expression Omnibus public microarray database indicated higher DUSP28, MUC1, MUC4, MUC5B, MUC16 MUC20 messenger RNA (mRNA) levels compared with normal pancreas tissues....

Pancreatic cancer is one of the most dangerous cancers with high mortality rates. Despite continuous efforts, there has been limited improvement in its prognosis. In this study, we prepared fermented extract Citrus unshiu peel (fCUP) from by-product after juice processing and then examined anticancer effects fCUP on human pancreatic cells. Treatment inhibited growth cells through induction caspase-3 cleavage both vitro vivo. also blocked migration activation intracellular signaling pathways...

The prognosis of pancreatic cancer remains dismal despite continuous and considerable efforts. Integrins (ITGs) are highly expressed in various malignant cancers. However, very few studies investigated the role integrin α3 (ITGα3) Here, we determined functional ITGα3 cancer. Analysis public microarray databases Western blot analysis indicated a unique expression human Silencing significantly inhibited viability migration cells. Notably, ablation resulted significant decrease epidermal growth...

The aim of the present study is to provide a rational background for silencing V-set and transmembrane domain containing 2 like (VSTM2L) in consort with recognising soluble VSTM2L against cholangiocarcinoma. A therapeutic target cholangiocarcinoma was selected using iterative patient partitioning (IPP) calculation, it verified by vitro silico analyses. as potential Silencing expression significantly attenuated viability survival cells through blockade intracellular signalling pathway. In...

Understanding the effects of topographic characteristics on tumor cell migration is important for development new anti‐migratory therapies. However, simplified in vitro culture systems often lead to inaccurate results regarding efficacy drugs. Histopathologically, glioblastoma multiform (GBM) cells migrate along orientation thin, elongated anatomical structures, such as white‐matter tracts. Here, a tapered microtract array platform which mimics features brain tissue introduced. This enables...

Citrus unshiu peel has been used empirically as a traditional medicine to improve bronchial asthma and blood circulation in northeast Asian nations, including Korea, Japan, China. In this study, we report the proangiogenic effects of aqueous extract (AECUP). human umbilical vein endothelial cells, AECUP significantly induced cellular migration capillary tube formation. We also demonstrated that markedly increased phosphorylation FAK ERK1/2 through integrin signaling pathway. Additionally,...

Contact-based pericellular interactions play important roles in cancer progression via juxtacrine signaling pathways. The present study revealed that hypoxia-inducible factor-1α (HIF-1α), induced even non-hypoxic conditions by cell-to-cell contact, was a critical cue responsible for the malignant characteristics of glioblastoma multiforme (GBM) cells through Notch1 signaling. Densely cultured GBM showed enhanced viability and resistance to temozolomide (TMZ) compared at low density. Ablating...