An 8‐month multicentre prospective randomized study aimed at comparing the effects of dopamine receptor agonists pramipexole (PPX; Mirapexin®) and pergolide (PRG; Permax®) as add‐on to L‐dopa therapy on depression [Montgomery Asberg Depression Rating Scale (MADRS)] in 41 non‐demented patients (25 men, 16 women) suffering from both mild or moderate advanced Parkinson's disease (PD). The assessment was performed by a blinded independent observer. Motor symptoms (UPDRS III), motor complications...

We report on the development of novel high-power light sources utilizing a Yb <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3+</sup> -doped phosphate fiber as gain element. This host presents several key benefits over silica, particularly much higher <sub xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> concentrations (up to 26 wt%), 50% weaker stimulated Brillouin scattering (SBS) cross...

We report the first mode-locked, thulium-doped fiber figure-eight laser. The mode-locked oscillator produces 1.5-ps pulses with 63 pJ of pulse energy at a 10.4-MHz repetition rate 3-nm bandwidth center wavelength 2034 nm. After amplification, are compressed to 370 fs ~ 50 nJ energy. can also operate in square regime, yielding stable from 100 ps 20 ns long per after amplification.

Abstract Gallium oxide (Ga 2 O 3 ) is an emerging wide‐bandgap transparent conductive (TCO) with potential applications for high‐power optical systems. Herein, Ga fabricated nanostructures are described, which demonstrate laser induced damage threshold (LIDT). Furthermore, the demonstration of electron accelerator based on gratings reported. These unique provide acceleration gradients exceeding those possible conventional RF accelerators due to high breakdown . In addition, and performance a...

Increasing bacterial resistance to antibiotics is one of the most serious problems in current medicine. An important factor contributing growing prevalence multiresistant bacteria application antibiotics. This study aimed at analyzing development Enterobacteriaceae selected beta-lactam, fluoroquinolone and aminoglycoside University Hospital Olomouc assessing effect selection pressure these antibiotics.For period between 1 January 2000 31 December 2011, Klebsiella pneumoniae, Escherichia...

We present the demonstration of phase-dependent laser acceleration and deflection electrons using a symmetrically driven silicon dual pillar grating structure. show that exciting an evanescent inverse Smith-Purcell mode on each side can produce hyperbolic cosine sine modes, depending relative excitation phase side. Our devices accelerate sub-relativistic 99.0 keV kinetic energy by 3.0 over 15 μm distance with accelerating gradients 200 MeV/m 40 nJ, 300 fs, 1940 nm pulses from optical...

Near-stoichiometric lithium tantalate (SLT) crystals were produced from congruent by vapor transport equilibration, and several important optical ferroelectric properties measured. The effect of conditions surface preparation on reproducible engineering SLT has been studied. Control these effects along with dramatic decreases in the sensitivity to photorefractive damage 532 nm absorption allowed near-room-temperature generation 10 W continuous wave radiation second harmonic 29 1064 a 4 cm...

We demonstrated a stable degenerate synchronously pumped femtosecond optical parametric oscillator (SPOPO) as divide-by-2 subharmonic generator. The SPOPO exhibited passive all-optical self-phase-locking between the pump and signal/idler thus required no external electronic feedback to produce phase-locked subharmonic. employed type I phase-matched, 1-mm-long, periodically poled MgO:LiNbO3 crystal nonlinear gain element an 80 MHz mode-locked Ti:sapphire laser with 180 fs pulses tuned at 775...

Klebsiella pneumoniae belongs to important nosocomial pathogens causing mainly hospital-acquired infections. Beta-lactam antibiotics are frequently used in the treatment of infections caused by K. pneumoniae, but their selection pressure bacteria become resistant. Excessive use third-generation cephalosporins is a risk factor for occurrence and spread ESBL-producing bacterial strains. The goal this study was describe utilization analyse on University Hospital Olomouc.Data hospital were...

We report on a system that produces 19 W of diffraction-limited radiation at 532 nm through single-pass frequency doubling the output 1064 Yb <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3+</sup> -doped fiber MOPA in periodically poled near-stoichiometric lithium tantalate (PPSLT) crystal. The was stable level for over one hour with no signs photorefraction. green power is believed to be limited by infrared-induced thermal dephasing PPSLT

Abstract Background Many common drugs have not been licensed for use in children. Methods This study evaluated the incidence of unlicensed and off-label prescriptions at Department Pediatrics during a period six months. A total 8,559 4,282 children were processed. Results Off-label found 9.01% 1.26% all prescriptions, respectively. Unlicensed significantly more boys (1.5%) than girls (1.0%) (p = 0.037). There was no significant difference between (9.0%) (9.1%) 0.89). The prescription...

Aims: To determine the extent of vancomycin removal and pharmacokinetics in septic patients with AKI using daily hemodialysis polysulphone high-flux low-flux membrane. Methods: Five received 6 h dialysis membrane, four Vancomycin was administered over last hour dialysis. The maintenance dose adjusted based on pre-hemodialysis serum concentrations. Patients were followed up for two days. Results: Median percentage by membrane 17% (8-38%) 31% (13-43%). clearance only moderately higher (median...

Digital subtraction angiography (DSA) is considered to be the 'gold standard' for confirmation of severe (70-99%) stenoses internal carotid arteries (ICAs). However, it associated with a risk complications. The aim this study was assess accuracy ultrasonography (US), computed tomographic (CTA), and their combined use detection quantification stenoses, when compared DSA. Severe ICA were diagnosed by US in set 29 patients. All patients also underwent CTA Sensitivity, specificity, positive...

Adverse drug reactions (ADRs) are common problems in both paediatric and adult medicine. The aim of this study was to prospectively identify the ADRs causing hospital admission children identification risk factors involved drugs. performed at University Hospital Olomouc, Czech Republic. All patients aged 19 years or under admitted were included study, all admissions for screened a period 9 months. Suspected subsequently evaluated detail, causality assessment undertaken determine whether each...

In this work, we design and demonstrate a compact electron source that combines an integrated silicon nanotip photoemitter with silicon-based electrostatic lens. The lens simultaneously accelerates electrons to 30 keV focuses the resulting beam 0.4 μm (RMS) diameter 62 pm-rad normalized emittance at distance of 20 mm from cathode. nature provides compelling for dielectric laser accelerator (DLA) beamlines, ultrafast diffraction, or microscopy. Driven by 220 fs, 1960 nm pulsed beam, currents...

The aims of this study were: (i) to monitor changes in central facial paresis patients with stroke after orofacial therapy, using functional scales and video analysis the face; (ii) investigate correlations between movement mental function stroke.A prospective blind randomized paresis. status experimental group 50 cases treated regulation therapy was compared 49 control 4 weeks rehabilitation.There were movement, evaluated House-Brackmann Grading System (HBDS), clinical range two-dimensional...

Intravital microscopy is a key means of monitoring cellular function in live organisms, but surgical preparation animal for often time-consuming, requires considerable skill, and limits experimental throughput. Here we introduce spatially precise (<1-µm edge precision), high-speed (<1 s), largely automated, economical protocol microsurgical animals optical imaging. Using 193-nm pulsed excimer laser the fruit fly as model, created observation windows (12- to 350-µm diameters) exoskeleton....