A5101471001- Immune Response and Inflammation
- Sepsis Diagnosis and Treatment
- Genetic Syndromes and Imprinting
- Cancer-related gene regulation
- Immune cells in cancer
- Extracellular vesicles in disease
- Kruppel-like factors research
- Circular RNAs in diseases
- Galectins and Cancer Biology
- Barrier Structure and Function Studies
Second Affiliated Hospital of Zhejiang University
2022
Hangzhou First People's Hospital
2020-2022
Zhejiang University
2020-2022
Affiliated Hospital of Nantong University
2021
Nantong University
2021
KLF4 is implicated in tumor progression of pancreatic cancer, but the molecular regulatory mechanism needs to be further specified. We aimed probe malignant cancer. qRT-PCR or western blot was completed test levels predicted genes. Dual-luciferase and chromatin immunoprecipitation (ChIP) assays were designed validate binding between Cell viability oncogenicity detection used for vitro vivo functional assessment. a downstream target miR-135b-5p. could regulate GPRC5A level. MiR-135b-5p...
Vascular endothelial hyperpermeability and barrier disruption are involved in the initiation development of sepsis. M1 macrophages promote inflammation sepsis by releasing pro-inflammatory cytokines chemokines. This study was designed to investigate functional relationships between human umbilical vein cells (HUVECs), as well underlying molecular mechanisms.HUVECs were co-cultured with THP-1-derived pretreated or without rosiglitazone (RSG), a peroxisome proliferator-activated receptor...
Abstract Sepsis is a disease that characterized by severe systemic inflammatory response to microbial infection and lipopolysaccharide (LPS) well-known inducer of sepsis, as well endothelial cell hyperpermeability. In the present study, we confirm elevation CXC chemokine ligand 13 (CXCL13) in sepsis patients. We also show LPS exposure increases release CXCL13, mRNA protein expression CXCL13 its receptor, receptor 5 (CXCR5) human umbilical vein cells (HUVECs) dose- time-dependent manner....