A5046531172- Meat and Animal Product Quality
- Muscle Physiology and Disorders
- Animal Nutrition and Physiology
- Muscle metabolism and nutrition
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Pharmacological Effects and Assays
- Pancreatic function and diabetes
- Growth Hormone and Insulin-like Growth Factors
- Biochemical effects in animals
- Cardiomyopathy and Myosin Studies
- Ruminant Nutrition and Digestive Physiology
- Effects of Environmental Stressors on Livestock
- Muscle activation and electromyography studies
- Mitochondrial Function and Pathology
- Genetic and phenotypic traits in livestock
- Spectroscopy and Chemometric Analyses
- Bee Products Chemical Analysis
- Animal Genetics and Reproduction
- Reproductive Physiology in Livestock
- Genetic Syndromes and Imprinting
- Calpain Protease Function and Regulation
- Exercise and Physiological Responses
- Metabolomics and Mass Spectrometry Studies
- Neurogenetic and Muscular Disorders Research
Virginia Tech
2015-2024
NHS England
2022
Purdue University West Lafayette
2003-2020
University of Agriculture in Krakow
2020
University of Arkansas at Fayetteville
2020
The Ohio State University
2020
United States Department of Agriculture
2020
University of Bologna
2020
Baker Hughes (United States)
2010-2012
Weizmann Institute of Science
2011
The objective of this study was to establish the developmental pattern and tissue specificity porcine myostatin expression evaluate in skeletal muscle during circumstances which growth altered. Northern blot analysis revealed two transcripts (1.5 0.8 kb). Myostatin mRNA detected whole fetuses at 21 35 days markedly increased (P < 0.05) by 49 days. At birth, abundance longissimus had declined significantly from that day 105 gestation continued decrease its lowest level 2 wk postnatally (4 kg...
ABSTRACT Sixty steaks with various degrees of marbling and color were subjected to sensory evaluation image processing. Marbling scores assigned each steak USDA score cards a lean guide. Images recorded for under the same conditions as used analysis. Steak images processed characteristics. Image processing effectively predicted (R 2 = 0.86) 0.84). was an effective tool determining quality attributes fresh meat.
The signal transduction cascades that maintain muscle mass remain to be fully defined. Herein, we report inhibition of extracellular signal-regulated kinase 1/2 (ERK1/2) signaling in vitro decreases myotube size and protein content after 3-day treatment with a MEK inhibitor. Neither p38 nor JNK inhibitors had any effect on or morphology. ERK1/2 also upregulated gene transcription atrogin-1 muscle-specific RING finger 1 downregulated the phosphorylation Akt its downstream kinases. Forced...
As a tissue, muscle has the unique ability to switch its metabolic source of ATP, energy currency underpinning function. During oxygen debt, such as that occurring immediately following death animals, anaerobic metabolism is initiated in an attempt restore homeostasis within muscle. The cascade biochemical events are paramount context meat quality. This review revisits this reasonably well-known subject but takes new perspective by drawing on understanding outside traditional discipline...
Given that cellular O-GlcNAcylation levels are thought to be real-time measures of nutrient status and dysregulated O-GlcNAc signaling is associated with insulin resistance, we evaluated the role transferase (OGT), enzyme mediates O-GlcNAcylation, in skeletal muscle. We assessed muscle from obese, type 2 diabetic people, characterized muscle-specific OGT knockout (mKO) mice metabolic cages measured energy expenditure substrate utilization pattern using indirect calorimetry. Whole body...
World meat production must increase substantially to support current projections in population growth over the next 30 years. However, maximizing product quality remains a focus for many industry, as incremental increases often signal potential segment profitability. Moreover, also address concerns raised by an ever-growing affluent society demanding greater eating satisfaction. Production strategies and valued endpoints differ worldwide, though this makes global marketing of challenging....
Three main fiber types (one slow [type I] and two fast IIA IIB] can be distinguished using conventional actomyosin ATPase (AM-ATPase) histochemistry after acidic pretreatment in mature pig skeletal muscle. We report the isolation, characterization, identification of four adult 3′-untranslated regions corresponding to I, IIA, IIB, IIX myosin heavy chains (MyHC) from a cDNA library. Identification different type II clones was based on sequence homology, situ hybridizations (ISH), AM-ATPase...
Interrelationships among concentrations and maturation of intramuscular collagen, serum concentration hydroxyproline testosterone meat tenderness were determined in growing bulls steers. Sixty-four Charolais X Angus assigned to sex treatment groups (intact or castrate) slaughter (9, 12, 15 18 mo age). Animals bled at 30-min intervals via intrajugular catheters between 0600 1400 beginning 48 h before slaughter. Serum each sample from four samples steers; was the last both sexes. Testosterone...
Skeletal muscle is composed of diverse fiber types, yet the underlying molecular mechanisms responsible for this diversification remain unclear. Herein, we report that extracellular signal-regulated kinase (ERK) 1/2 pathway, but not p38 or c-Jun NH(2)-terminal (JNK), preferentially activated in fast-twitch muscles. Pharmacological blocking ERK1/2 pathway increased slow-twitch type-specific reporter activity and repressed those associated with phenotype vitro. Overexpression a constitutively...
Extent of postmortem pH decline influences meat quality development. To better understand physiological determination ultimate (pHu), we utilized female and castrated male pigs from a line whose selection index includes differentiated pHu. All genotypes AMP-activated protein kinase γ3 subunit (AMPKγ3) V199I site were present. The mutant 199II genotype increased pHu, but only in males. Genotype affected glycolytic potential (GP), GP was weakly associated with A subset animals selected based...