A5048477407- Atherosclerosis and Cardiovascular Diseases
- Immune Cell Function and Interaction
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Gut microbiota and health
- Helicobacter pylori-related gastroenterology studies
- Cancer Immunotherapy and Biomarkers
- Systemic Lupus Erythematosus Research
- Aortic aneurysm repair treatments
- Inflammasome and immune disorders
- Cytokine Signaling Pathways and Interactions
- IL-33, ST2, and ILC Pathways
- Adipokines, Inflammation, and Metabolic Diseases
- Psoriasis: Treatment and Pathogenesis
- Angiogenesis and VEGF in Cancer
- Biomarkers in Disease Mechanisms
- Tryptophan and brain disorders
- Immune Response and Inflammation
- Vitamin D Research Studies
- Gastrointestinal motility and disorders
- Pancreatitis Pathology and Treatment
California University of Pennsylvania
2024
Fox Chase Cancer Center
2016-2023
University of Chicago
2021
Australian Library and Information Association
2018
Abstract Abdominal aortic aneurysm (AAA) is a prevalent life-threatening disease, where wall degradation mediated by accumulated immune cells. Although cytokines regulate inflammation within the aorta, their contribution to AAA via distant alterations, particularly in control of hematopoietic stem cell (HSC) differentiation, remains poorly defined. Here we report pathogenic role for interleukin-27 receptor (IL-27R) AAA, as genetic ablation IL-27R protects mice from disease development....
Abstract Although inflammatory mechanisms driving hepatocellular carcinoma (HCC) have been proposed, the regulators of anticancer immunity in HCC remain poorly understood. We found that IL27 receptor (IL27R) signaling promotes development vivo. High IL27EBI3 cytokine or IL27RA expression correlated with poor prognosis for patients HCC. Loss IL27R suppressed vivo two different models hepatocarcinogenesis. Mechanistically, signaling within tumor microenvironment restrains cytotoxicity innate...
Abstract Myeloid cells, key players in atherosclerosis, take up and present antigens, leading to systemic local T cell activation. The recruitment activation of immune cells the aorta atherosclerosis is regulated by adhesion molecules, chemokines cytokines. IL-27R an immunoregulatory signaling nod autoimmune infectious pathologies. was shown suppress however it’s possible role myeloid accumulation not understood. Here we demonstrate that Apoe − / Il27ra mice fed with “Western Diet” for 7 or...
Abstract The REG / Reg gene locus encodes for a conserved family of potent antimicrobial but also pancreatitis-associated proteins. Here we investigated whether REG/Reg members differ in their baseline expression levels and abilities to be regulated the pancreas gut upon perturbations. We found, human mouse, differed isoform preferences, with duodenum most resembling pancreas. Pancreatic acinar cells intestinal enterocytes were dominant producers. Intestinal symbiotic microbes same, select...
Atherosclerosis is a lipid-driven inflammatory disease characterized by the progressive plaque growth in vessels. Cytokines are important mediators of inflammation and atherosclerosis. While pro-inflammatory cytokines were extensively investigated, little known about role anti-inflammatory as to their ability control vascular inflammation. We tested whether immunoregulatory IL-27R signaling mouse models found that atherosclerosis-prone mice with hematopoietic deficiency ( Ldlr -/-...
Atherosclerosis is lipid-driven chronic inflammatory disease of the arterial wall mediated by innate and adaptive immune responses. Inflammation promotes development atherosclerotic plaques. Cytokines are soluble mediators inflammation important players in pathogenesis atherosclerosis. IL-23, a cytokine IL-6/IL-12 cytokines superfamily produced myeloid cells regulates production IL-17 IL-22 T helper producing (Th17) cells, lymphoid type 3 (ILC3) gamma delta various auto-inflammatory...
<div>Abstract<p>Although inflammatory mechanisms driving hepatocellular carcinoma (HCC) have been proposed, the regulators of anticancer immunity in HCC remain poorly understood. We found that IL27 receptor (IL27R) signaling promotes development <i>in vivo</i>. High IL27EBI3 cytokine or <i>IL27RA</i> expression correlated with poor prognosis for patients HCC. Loss IL27R suppressed vivo</i> two different models hepatocarcinogenesis. Mechanistically,...
<div>Abstract<p>Although inflammatory mechanisms driving hepatocellular carcinoma (HCC) have been proposed, the regulators of anticancer immunity in HCC remain poorly understood. We found that IL27 receptor (IL27R) signaling promotes development <i>in vivo</i>. High IL27EBI3 cytokine or <i>IL27RA</i> expression correlated with poor prognosis for patients HCC. Loss IL27R suppressed vivo</i> two different models hepatocarcinogenesis. Mechanistically,...
Supplementary Data from IL27 Signaling Serves as an Immunologic Checkpoint for Innate Cytotoxic Cells to Promote Hepatocellular Carcinoma
Supplementary Data from IL27 Signaling Serves as an Immunologic Checkpoint for Innate Cytotoxic Cells to Promote Hepatocellular Carcinoma
Abdominal Aortic Aneurysm (AAA) is a vascular disease, where aortic wall degradation mediated by accumulated immune cells. Several cytokines have been suggested to play role in AAA, however the of cell accumulation and AAA progression remains poorly defined. Here we report an unexpected IL-27R signaling development AAA. We found that animal model prolonged infusion Angiotensin (Ang) II robustly induced formation hyperlipidemic Apoe -/- Il27ra +/- mice but failed do so mice. This mitigation...
Atherosclerosis is lipid-driven, chronic inflammatory disease of the arterial wall. While commensal microbiota involved in distal regulation systemic immune responses, how this distant connection influences development atherosclerosis and what are underlying mechanisms remains largely unknown. In a mouse model atherosclerosis, we found, unexpectedly, that was augmented when expression otherwise cytokine IL23 ablated. its immediate downstream target IL22 restrict by preventing outgrowth...
Abstract Abdominal Aortic Aneurysm (AAA) is a vascular disease, where aortic wall degradation mediated by accumulated immune cells. Though cytokines regulate the inflammatory milieu within wall, their contribution to AAA through distant alterations, particularly in control of hematopoietic stem cells proliferation and myeloid cell differentiation remains poorly defined. Here we report an unexpected pathogenic role for interleukin-27 receptor (IL-27R) development as genetic inactivation...
While microbiota is involved in the regulation of immunity, interplay between cytokine signaling and atherosclerosis remains unknown. We found that IL23 its downstream IL22 restricted by repressing pro-atherogenic microbiota. Inactivation IL23-IL22 led to deterioration intestinal barrier, dysbiosis expansion bacteria with distinct biosynthetic metabolic properties, as determined microbiome profiling functional metagenomic sequencing. Cytokine-driven alterations cause systemic increase...
Abstract Atherosclerosis is lipid-driven, chronic inflammatory disease of the arterial wall. While commensal microbiota involved in distal regulation systemic immune responses, how this distant connection influences development atherosclerosis and what are underlying mechanisms remains largely unknown. In a mouse model atherosclerosis, we found that was augmented when expression otherwise cytokine IL23 ablated. its immediate downstream target IL22 restrict by preventing outgrowth microbiota,...
Abstract Abdominal Aortic Aneurysm (AAA) is a vascular disease, where aortic wall degradation in part mediated by the accumulation of immune cells leading to rupture and bleeding which often fatal for patient. Smoking, age, male gender, hypertension atherosclerosis are major risk factors, however mechanism AAA development still elusive. Though cytokines regulate inflammatory milieu within wall, their possible role systemic regulation this particularly control hematopoietic stem cell...
Abstract Hepatocellular carcinoma (HCC) is the most common form of liver cancer with poor survival and limited therapeutic options. HCC has different etiologies, typically associated viral or carcinogenic insults fatty disease underlying chronic inflammation presents as a major unifying mechanism for tumor promotion. On other hand, mechanisms how inflammatory response can regulate anti-cancer immunity in remain incompletely understood. Interleukin (IL)-27 receptor signaling plays an...
While microbiota regulates immunity and was suggested to play a role in atherosclerosis, the specific of cytokine signaling intestinal epithelial cells (IEC) control microbiota, inflammation, vascular disease remains unknown. We previously showed that IL-23 enforces barrier, controls pro-atherogenic bacteria, metabolites, activation myeloid cells, protects from atherosclerosis. Here we investigate IL-23-regulated IL-17 IEC using newly generated Ldlr -/- Il17rc fl/fl VillinCre + mice. found...