A5101866345- Computational Drug Discovery Methods
- Synthesis and biological activity
- Chemical and Physical Properties in Aqueous Solutions
- Receptor Mechanisms and Signaling
- Chemical Thermodynamics and Molecular Structure
- Circadian rhythm and melatonin
- Multicomponent Synthesis of Heterocycles
- Bacterial Genetics and Biotechnology
- Chemical Synthesis and Analysis
- Cancer-related Molecular Pathways
- Photoreceptor and optogenetics research
- Thermodynamic properties of mixtures
- Synthesis and Characterization of Heterocyclic Compounds
- Chemical Synthesis and Reactions
- Ion channel regulation and function
- Protein Kinase Regulation and GTPase Signaling
- Inorganic and Organometallic Chemistry
- Prostate Cancer Treatment and Research
- Neuropeptides and Animal Physiology
- Electrochemical Analysis and Applications
- Neuroendocrine regulation and behavior
- Natural Antidiabetic Agents Studies
- Diabetes Treatment and Management
- Analytical Chemistry and Chromatography
- Toxin Mechanisms and Immunotoxins
Retina Vitreous Associates of Florida
2024
Bristol-Myers Squibb (United States)
2023-2024
Lovely Professional University
2015-2023
Adesh University
2023
Punjab Institute of Medical Sciences
2017
Salk Institute for Biological Studies
2012-2016
SRI International
2013-2015
Sant Longowal Institute of Engineering and Technology
2009-2011
National Institute of Pharmaceutical Education and Research
2008
National Institute of Pharmaceutical Education and Research
2007
In mammals, a small population of intrinsically photosensitive retinal ganglion cells (ipRGCs) plays key role in the regulation nonvisual photic responses, such as behavioral responses to light, pineal melatonin synthesis, pupillary light reflex, and sleep latency. These ipRGCs also express melanopsin (Opn4), putative opsin-family photopigment that has been shown play mediating these responses. Melanopsin is required for function this inner pathway, but its precise generating not yet...
Chronic sleep deprivation perturbs the circadian clock and increases susceptibility to diseases such as diabetes, obesity, cancer. Increased inflammation is one of common underlying mechanisms these diseases, thus raising a hypothesis that circadian-oscillator components may regulate immune response. Here we show absence core component protein cryptochrome (CRY) leads constitutive elevation proinflammatory cytokines in cell-autonomous manner. We observed NF–κB kinase A (PKA) signaling...
Modulating the chemical composition of cereblon (CRBN) binders is a critical step in optimization process protein degraders that seek to hijack function this E3 ligase. Small structural changes can have profound impacts on overall profile these compounds, including depth on-target degradation, neosubstrate degradation selectivity, as well other drug-like properties. Herein, we report design and synthesis series novel CRBN binding moieties. These were evaluated for common neosubstrates Aiolos...
Most prostate cancers express the androgen receptor (AR), and tumor growth progression are facilitated by exceptionally low levels of systemic or intratumorally produced androgens. Thus, absolute inhibition signaling axis remains goal current therapeutic approaches to treat cancer (PCa). Paradoxically, high dose androgens also exhibit considerable efficacy as a treatment modality in patients with late-stage metastatic PCa. Here we show that androgens, functioning through an AR monomer,...
Parathyroid hormone (PTH) and parathyroid hormone–related peptide (PTHrP), acting through the osteoblast PTH1 receptor (PTH1R), play important roles in bone remodeling. Intermittent administration of PTH(1-34) (teriparatide) leads to formation, whereas continuous paradoxically resorption. Activation PTH1R promotes regulation multiple signaling pathways, including G<sub>s</sub>/cAMP/protein kinase A, G<sub>q</sub>/calcium/protein C, <i>β</i>-arrestin recruitment, extracellular signal-related...
Homers are scaffolding proteins that bind G protein–coupled receptors (GPCRs), inositol 1,4,5-triphosphate (IP3) (IP3Rs), ryanodine receptors, and TRP channels. However, their role in Ca2+ signaling vivo is not known. Characterization of pancreatic acinar cells from Homer2−/− Homer3−/− mice showed Homer 3 has no discernible these cells. In contrast, we found 2 tunes intensity by GPCRs to regulate the frequency [Ca2+]i oscillations. Thus, deletion increased stimulus increasing potency for...
Objective: Design of novel antimicrobial peptides and study through the molecular docking.Methods: The structures were drawn in ChemBiodraw ultra by help 3D, all energy minimized theMM2 method converted to pdbextension file which is readable at ADT interface. AutoDock Vina (ADT) 1.5.6 software used for docking purposes.Results: Eight (AMPs) designed based on theMP196antimicrobial peptide. Among these KP_03R (FWRWRW-NH2) showed good binding affinity. These also stereochemical influence...
Phytochemical screening and Antimicrobial activity of the leaves Memecylon umbellatum burm. F.Subban Murugesan, Annamalai Pannerselvam, Arumugame Chanemougame Tangavelou
Abstract The androgen receptor (AR) is a key driver of the cellular processes that contribute to pathology prostate cancers at most stages, and drugs inhibit activity this or interfere with biosynthesis have become cornerstone treatments for cancer. While both types therapy had significant positive impact on disease progression overall survival, de novo acquired resistance remains an impediment durable clinical response in patients metastatic castration-resistant cancer (mCRPC). mechanisms...
Gbetagamma subunits modulate several distinct molecular events involved with G protein signaling. In addition to regulating effector proteins, help anchor Galpha the plasma membrane, promote interaction of receptors, stabilize binding GDP suppress spurious activation, and provide membrane contact points for protein-coupled receptor kinases. have also been shown inhibit activities GTPase-activating proteins (GAPs), both phospholipase C (PLC)-betas RGS when assayed in solution under single...